| Identification |
|---|
| HMDB Protein ID
| CDBP04366 |
| Secondary Accession Numbers
| Not Available |
| Name
| N-acetylated-alpha-linked acidic dipeptidase-like protein |
| Description
| Not Available |
| Synonyms
|
- 100 kDa ileum brush border membrane protein
- I100
- Ileal dipeptidylpeptidase
- NAALADase L
|
| Gene Name
| NAALADL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in peptidase activity |
| Specific Function
| NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC |
| GO Classification
|
| Function |
| catalytic activity |
| hydrolase activity |
| peptidase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Single-pass type II membrane protein
- Apical cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q12 |
| SNPs
| NAALADL1 |
| Gene Sequence
|
>2223 bp
ATGCAGTGGACGAAGGTGTTGGGGCTGGGGCTGGGGGCTGCTGCCCTCTTGGGGCTGGGG
ATCATCCTCGGCCACTTTGCCATCCCCAAAAAAGCCAACTCACTGGCCCCCCAGGACCTG
GACCTGGAGATCCTGGAGACCGTCATGGGGCAGCTGGATGCCCACAGGATCCGGGAGAAC
CTCAGAGAACTCTCCAGGGAGCCACACCTGGCCTCCAGCCCTCGGGATGAGGACCTGGTG
CAGCTGCTGCTGCAGCGCTGGAAGGACCCAGAGTCAGGCCTGGACTCGGCCGAGGCCTCC
ACGTACGAAGTGCTGCTGTCCTTCCCTAGCCAGGAGCAGCCCAACGTCGTGGACATCGTG
GGCCCCACTGGGGGCATCATCCACTCCTGCCACCGGACTGAGGAGAACGTGACCGGGGAG
CAAGGGGGGCCAGATGTGGTACAACCCTATGCTGCCTATGCTCCTTCTGGAACCCCACAG
GGCCTCCTCGTCTATGCCAACCGGGGCGCGGAAGAAGACTTTAAGGAGCTACAGACTCAG
GGCATCAAACTTGAAGGCACCATTGCCCTGACTCGATATGGGGGTGTAGGGCGTGGGGCC
AAGGCTGTGAACGCTGCCAAGCACGGGGTAGCTGGGGTGCTGGTGTACACAGACCCTGCC
GACATCAACGATGGGCTGAGCTCACCCGACGAAACCTTTCCCAACTCCTGGTACCTGCCC
CCCTCAGGAGTGGAGCGAGGCTCCTACTACGAGTATTTTGGGGACCCTCTGACTCCCTAC
CTTCCAGCCGTCCCCTCTTCCTTCCGCGTGGACCTTGCCAATGTCTCCGGATTTCCCCCA
ATTCCTACACAGCCCATTGGCTTCCAGGATGCAAGAGACCTGCTCTGTAACCTCAACGGA
ACTTTGGCCCCAGCCACCTGGCAGGGAGCACTGGGCTGCCACTACAGGTTGGGTCCCGGC
TTCCGGCCTGACGGAGACTTCCCAGCAGACAGCCAGGTGAATGTGAGCGTCTACAACCGC
CTGGAGCTGAGGAACTCTTCCAACGTCCTGGGCATCATCCGTGGGGCTGTGGAGCCTGAT
CGCTACGTGCTGTATGGGAACCACCGAGACAGCTGGGTGCACGGGGCTGTGGACCCCAGC
AGTGGCACCGCCGTCCTCCTGGAGCTCTCCCGTGTCCTGGGGACCCTGCTGAAGAAGGGC
ACCTGGCGTCCTCGCAGATCAATCGTGTTTGCGAGCTGGGGGGCTGAGGAGTTTGGGCTC
ATTGGCTCCACGGAATTCACAGAAGAGTTCTTCAACAAGCTGCAGGAGCGCACGGTGGCC
TACATCAACGTGGACATCTCGGTGTTTGCCAACGCTACCCTTAGGGTGCAGGGGACGCCC
CCTGTCCAGAGCGTCGTCTTCTCTGCAACCAAAGAGATCCGCTCACCAGGCCCTGGCGAC
CTGAGCATCTACGACAACTGGATCCGGTACTTCAACCGCAGCAGCCCGGTGTACGGCCTG
GTCCCCAGCTTGGGTTCTCTGGGTGCTGGCAGCGACTATGCACCCTTCGTTCACTTCCTG
GGCATCTCCTCCATGGACATTGCCTATACCTATGACCGGAGCAAGACTTCAGCCAGGATC
TACCCCACCTACCACACAGCCTTTGACACCTTTGACTATGTGGACAAGTTTTTGGACCCG
GGCTTCAGCAGCCATCAGGCTGTGGCCCGGACAGCGGGGAGTGTGATTCTCCGGCTCAGT
GACAGCTTCTTCCTGCCCCTCAAAGTCAGTGACTACAGTGAGACACTCCGCAGCTTCCTG
CAGGCAGCCCAGCAAGATCTTGGGGCCCTGCTGGAGCAGCACAGCATCAGCCTGGGGCCT
CTGGTGACTGCAGTGGAGAAGTTTGAGGCAGAAGCTGCAGCCTTGGGCCAACGCATATCA
ACACTGCAGAAGGGCAGCCCTGACCCCCTGCAGGTCCGGATGCTCAATGACCAGTTGATG
CTCTTGGAACGGACCTTTCTGAACCCTAGAGCCTTCCCAGAGGAACGCTACTACAGCCAT
GTGCTCTGGGCACCTCGCACGGGCTCCGTAGTCACATTCCCGGGCCTATCCAATGCCTGC
TCCAGGGCCAGGGACACAGCTTCTGGATCTGAAGCTTGGGCTGAGGTCCAGAGACAGCTC
AGCATTGTGGTGACAGCCCTGGAGGGTGCGGCAGCCACCCTGAGGCCTGTGGCTGACCTC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 740 |
| Molecular Weight
| 80566.9 |
| Theoretical pI
| 5.14 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>N-acetylated-alpha-linked acidic dipeptidase-like protein
MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN
LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEAXTYEVLLSFPSQEQPNVVDIV
GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ
GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP
PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG
TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD
RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL
IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD
LSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARI
YPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFL
QAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLM
LLERTFLNPRAFPEERYYSHVLWAPSHGLRSHIPGLSNACSRARDTASGSEAWAEVQRQL
SIVVTALEGAAATLRPVADL
|
| External Links |
|---|
| GenBank ID Protein
| 57232740 |
| UniProtKB/Swiss-Prot ID
| Q9UQQ1 |
| UniProtKB/Swiss-Prot Entry Name
| NALDL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_005468.2 |
| GeneCard ID
| NAALADL1 |
| GenAtlas ID
| NAALADL1 |
| HGNC ID
| HGNC:23536 |
| References |
|---|
| General References
| Not Available |