| Identification |
|---|
| HMDB Protein ID
| CDBP04356 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADPH oxidase organizer 1 |
| Description
| Not Available |
| Synonyms
|
- NADPH oxidase regulatory protein
- Nox organizer 1
- Nox-organizing protein 1
- SH3 and PX domain-containing protein 5
|
| Gene Name
| NOXO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity |
| GO Classification
|
| Function |
| binding |
| protein binding |
| lipid binding |
| phospholipid binding |
| phosphoinositide binding |
| Process |
| cellular process |
| cell communication |
|
| Cellular Location
|
- Peripheral membrane protein
- Cytoplasmic side
- Isoform 3:Cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p13.3 |
| SNPs
| NOXO1 |
| Gene Sequence
|
>1131 bp
ATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGG
CTCCAAACGTTTGCCTTCTCTGTGCGCTGGTCAGACGGCAGCGACACCTTCGTGCGCAGG
AGTTGGGACGAATTCAGGCAGCTCAAGAAGACCCTCAAGGAGACCTTCCCGGTGGAGGCG
GGCCTGCTGCGGAGATCTGACCGCGTTCTCCCAAAGCTTCTCGGTCAGGCCAGCCTGGAT
GCACCACTGTTGGGACGCGTGGGGCGCACGAGCCGCGGCCTGGCGCGCCTGCAGCTGTTG
GAAACCTATTCTCGGAGGCTGCTGGCGACTGCAGAGCGCGTGGCACGGAGCCCGACGATC
ACTGGCTTCTTCGCACCGCAACCCCTGGACCTGGAGCCCGCGCTGCCACCCGGCAGCCGG
GTGATCCTGCCCACCCCAGAGGAGCAGCCTCTTTCTCGCGCTGCGGGCCGCCTCTCCATC
CACAGTCTGGAGGCTCAGAGCCTGCGCTGCCTGCAGCCCTTCTGTACCCAGGACACGCGG
GATAGGCCTTTTCAGGCGCAGGCCCAGGAGAGCCTGGACGTGCTGCTGCGGCACCCCTCA
GGCTGGTGGCTGGTGGAGAACGAAGACCGGCAGACCGCCTGGTTTCCAGCGCCCTACCTG
GAGGAGGCGGCCCCGGGCCAAGGCCGGGAGGGAGGCCCGTCCCTAGGGAGCAGCGGTCCC
CAGTTCTGTGCTTCCCGCGCCTACGAGAGCAGCCGCGCAGATGAGCTGTCCGTGCCCGCG
GGGGCGCGCGTGCGCGTGTTGGAAACGTCAGACCGCGGCTGGTGGCTATGCAGGTACGGC
GACCGGGCGGGCCTACTCCCCGCGGTGCTGCTGCGGCCGGAAGGGCTGGGCGCTCTCCTG
AGCGGGACGGGGTTCCGTGGAGGAGACGACCCGGCGGGTGAGGCCCGGGGCTTCCCTGAA
CCCTCCCAGGCCACCGCCCCTCCCCCCACCGTGCCCACCCGACCTTCGCCGGGCGCCATC
CAGAGCCGCTGCTGCACCGTCACACGCAGGGCCCTGGAGCGGCGCCCACGGCGCCAGGGC
CGCCCTCGAGGGTGCGTGGACTCTGTGCCGCACCCCACGACGGAGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 376 |
| Molecular Weight
| 41252.3 |
| Theoretical pI
| 10.23 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>NADPH oxidase organizer 1
MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEA
GLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTI
TGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTR
DRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGP
QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL
SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQG
RPRGCVDSVPHPTTEQ
|
| External Links |
|---|
| GenBank ID Protein
| 41281828 |
| UniProtKB/Swiss-Prot ID
| Q8NFA2 |
| UniProtKB/Swiss-Prot Entry Name
| NOXO1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_172168.1 |
| GeneCard ID
| NOXO1 |
| GenAtlas ID
| NOXO1 |
| HGNC ID
| HGNC:19404 |
| References |
|---|
| General References
| Not Available |