| Identification |
|---|
| HMDB Protein ID
| CDBP04346 |
| Secondary Accession Numbers
| Not Available |
| Name
| tRNA pseudouridine synthase 3 |
| Description
| Not Available |
| Synonyms
|
- tRNA pseudouridylate synthase 3
- tRNA-uridine isomerase 3
|
| Gene Name
| PUS3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in RNA binding |
| Specific Function
| Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| nucleic acid binding |
| isomerase activity |
| pseudouridine synthase activity |
| intramolecular transferase activity |
| rna binding |
| Process |
| rna metabolic process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| rna modification |
| pseudouridine synthesis |
|
| Cellular Location
|
- Nucleus (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q24.2 |
| SNPs
| PUS3 |
| Gene Sequence
|
>1446 bp
ATGGCTTATAATGACACAGACAGAAACCAGACTGAGAAGCTCCTAAAAAGAGTACGAGAA
CTGGAGCAAGAGGTGCAAAGACTTAAAAAGGAACAGGCCAAAAATAAGGAGGACTCAAAC
ATTAGAGAAAATTCAGCAGGAGCTGGAAAAACTAAGCGTGCATTTGATTTCAGTGCTCAT
GGCCGAAGACACGTAGCCCTAAGAATAGCCTATATGGGCTGGGGATACCAGGGCTTTGCT
AGTCAGGAAAACACAAATAATACCATTGAAGAGAAACTGTTTGAAGCTCTAACCAAGACT
CGACTAGTAGAAAGCAGACAGACATCCAACTATCACCGATGTGGGAGAACAGATAAAGGA
GTTAGTGCCTTTGGACAGGTGATCTCACTTGACCTTCGCTCTCAGTTTCCAAGGGGCAGG
GATTCCGAGGACTTTAATGTAAAAGAGGAGGCTAATGCTGCTGCTGAAGAGATCCGTTAT
ACCCACATTCTCAATCGGGTACTCCCTCCAGACATCCGTATATTGGCCTGGGCCCCTGTA
GAACCAAGCTTCAGTGCTAGGTTCAGCTGCCTTGAGCGGACTTACCGCTATTTTTTCCCT
CGTGCTGATTTAGATATTGTAACCATGGATTATGCAGCTCAGAAGTATGTTGGCACCCAT
GATTTCAGGAACTTGTGTAAAATGGATGTAGCCAACGGTGTGATTAATTTTCAGAGGACT
ATTCTATCTGCTCAAGTACAGCTAGTGGGCCAGAGCCCAGGTGAGGGGAGATGGCAAGAA
CCTTTCCAGTTATGTCAGTTTGAAGTGACTGGCCAGGCATTCCTTTATCATCAAGTCCGA
TGTATGATGGCTATCCTCTTTCTGATTGGCCAAGGAATGGAGAAGCCAGAGATTATTGAT
GAGCTGCTGAATATAGAGAAAAATCCCCAAAAGCCTCAATATAGTATGGCTGTAGAATTT
CCTCTAGTCTTATATGACTGTAAGTTTGAAAATGTCAAGTGGATCTATGACCAGGAGGCT
CAGGAGTTCAATATTACCCACCTACAACAACTGTGGGCTAATCATGCTGTCAAAACTCAC
ATGTTGTATAGTATGCTACAAGGACTGGACACTGTTCCAGTACCCTGTGGAATAGGACCA
AAGATGGATGGAATGACAGAATGGGGAAATGTTAAGCCCTCTGTCATAAAGCAGACCAGT
GCCTTTGTAGAAGGAGTGAAGATGCGCACATATAAGCCCCTCATGGACCGTCCTAAATGC
CAAGGACTGGAATCCCGGATCCAGCATTTTGTACGTAGGGGACGAATTGAGCACCCACAT
TTATTCCATGAGGAAGAAACAAAAGCCAAAAGGGACTGTAATGACACACTAGAGGAAGAG
AATACTAATTTGGAGACACCAACGAAGAGGGTCTGTGTTGACACAGAAATTAAAAGCATC
ATTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 481 |
| Molecular Weight
| 55647.0 |
| Theoretical pI
| 7.53 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>tRNA pseudouridine synthase 3
MAYNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSAGAGKTKRAFDFSAH
GRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKG
VSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPV
EPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRT
ILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIID
ELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVKTH
MLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKC
QGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEENTNLETPTKRVCVDTEIKSI
I
|
| External Links |
|---|
| GenBank ID Protein
| 12276176 |
| UniProtKB/Swiss-Prot ID
| Q9BZE2 |
| UniProtKB/Swiss-Prot Entry Name
| PUS3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF325689 |
| GeneCard ID
| PUS3 |
| GenAtlas ID
| PUS3 |
| HGNC ID
| HGNC:25461 |
| References |
|---|
| General References
| Not Available |