| Identification |
|---|
| HMDB Protein ID
| CDBP04344 |
| Secondary Accession Numbers
| Not Available |
| Name
| Deoxyhypusine hydroxylase |
| Description
| Not Available |
| Synonyms
|
- Deoxyhypusine dioxygenase
- Deoxyhypusine monooxygenase
- HEAT-like repeat-containing protein 1
- hDOHH
|
| Gene Name
| DOHH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
|
| GO Classification
|
| Biological Process |
| post-translational protein modification |
| peptidyl-lysine modification to hypusine |
| Cellular Component |
| cytosol |
| Function |
| binding |
| Molecular Function |
| metal ion binding |
| deoxyhypusine monooxygenase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | eIF5A hypusination | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.3 |
| SNPs
| DOHH |
| Gene Sequence
|
>909 bp
ATGGTGACGGAGCAGGAGGTGGATGCCATCGGGCAGACGCTGGTGGACCCCAAGCAGCCC
CTGCAGGCCCGCTTCCGGGCGCTGTTCACGCTGCGTGGGCTCGGCGGCCCAGGCGCCATT
GCATGGATCAGCCAGGCCTTCGATGACGATTCCGCCCTGCTCAAGCACGAGCTGGCCTAC
TGCCTGGGCCAGATGCAGGATGCCCGCGCCATCCCCATGCTGGTGGACGTGCTGCAAGAC
ACCCGTCAGGAGCCCATGGTGCGCCATGAGGCAGGGGAGGCCCTGGGGGCCATCGGGGAC
CCGGAAGTTCTGGAGATCCTGAAGCAGTATTCCTCGGACCCCGTCATCGAGGTGGCCGAG
ACCTGCCAGCTGGCCGTGCGCAGGCTGGAGTGGCTGCAGCAGCACGGCGGGGAGCCGGCG
GCGGGACCCTACCTCTCCGTGGACCCTGCCCCGCCGGCTGAGGAGCGTGACGTGGGGCGC
CTGCGGGAGGCGCTGCTGGATGAGTCCCGGCCGCTCTTCGAGCGATACCGCGCCATGTTC
GCCCTGCGCAACGCGGGAGGCGAGGAGGCCGCCCTGGCGCTGGCCGAGGGTCTGCACTGT
GGGAGCGCCCTCTTCCGCCACGAGGTCGGCTACGTCCTGGGACAGCTGCAGCACGAGGCG
GCGGTGCCCCAGCTGGCGGCCGCCCTGGCCCGATGCACCGAGAACCCCATGGTGCGGCAC
GAGTGCGCGGAGGCCCTGGGCGCCATTGCCCGGCCCGCCTGCCTGGCCGCGCTGCAGGCT
CACGCGGACGACCCAGAGCGCGTGGTGCGTGAGAGCTGCGAGGTGGCTCTGGACATGTAT
GAGCACGAGACCGGGCGGGCCTTCCAGTACGCGGACGGCCTGGAGCAGCTGCGCGGGGCC
CCCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 302 |
| Molecular Weight
| 32903.885 |
| Theoretical pI
| 4.822 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Deoxyhypusine hydroxylase
MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAY
CLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAE
TCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMF
ALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRH
ECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGA
PS
|
| External Links |
|---|
| GenBank ID Protein
| 223633884 |
| UniProtKB/Swiss-Prot ID
| Q9BU89 |
| UniProtKB/Swiss-Prot Entry Name
| DOHH_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001145165.1 |
| GeneCard ID
| DOHH |
| GenAtlas ID
| DOHH |
| HGNC ID
| HGNC:28662 |
| References |
|---|
| General References
| Not Available |