Identification
HMDB Protein ID CDBP04343
Secondary Accession Numbers Not Available
Name G/T mismatch-specific thymine DNA glycosylase
Description Not Available
Synonyms
  1. Thymine-DNA glycosylase
Gene Name TDG
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity, hydrolyzing N-glycosyl compounds
Specific Function In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine
GO Classification
Function
double-stranded dna binding
mismatched dna binding
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing n-glycosyl compounds
nucleic acid binding
dna binding
structure-specific dna binding
Process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
dna metabolic process
dna repair
mismatch repair
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12q24.1
SNPs TDG
Gene Sequence
>1233 bp
ATGGAAGCGGAGAACGCGGGCAGCTATTCCCTTCAGCAAGCTCAAGCTTTTTATACGTTT
CCATTTCAACAACTGATGGCTGAAGCTCCTAATATGGCAGTTGTGAATGAACAGCAAATG
CCAGAAGAAGTTCCAGCCCCAGCTCCTGCTCAGGAACCAGTGCAAGAGGCTCCAAAAGGA
AGAAAAAGAAAACCCAGAACAACAGAACCAAAACAACCAGTGGAACCCAAAAAACCTGTT
GAGTCAAAAAAATCTGGCAAGTCTGCAAAATCAAAAGAAAAACAAGAAAAAATTACAGAC
ACATTTAAAGTAAAAAGAAAAGTAGACCGTTTTAATGGTGTTTCAGAAGCTGAACTTCTG
ACCAAGACTCTCCCCGATATTTTGACCTTCAATCTGGACATTGTCATTATTGGCATAAAC
CCGGGACTAATGGCTGCTTACAAAGGGCATCATTACCCTGGACCTGGAAACCATTTTTGG
AAGTGTTTGTTTATGTCAGGGCTCAGTGAGGTCCAGCTGAACCATATGGATGATCACACT
CTACCAGGGAAGTATGGTATTGGATTTACCAACATGGTGGAAAGGACCACGCCCGGCAGC
AAAGATCTCTCCAGTAAAGAATTTCGTGAAGGAGGACGTATTCTAGTACAGAAATTACAG
AAATATCAGCCACGAATAGCAGTGTTTAATGGAAAATGTATTTATGAAATTTTTAGTAAA
GAAGTTTTTGGAGTAAAGGTTAAGAACTTGGAATTTGGGCTTCAGCCCCATAAGATTCCA
GACACAGAAACTCTCTGCTATGTTATGCCATCATCCAGTGCAAGATGTGCTCAGTTTCCT
CGAGCCCAAGACAAAGTTCATTACTACATAAAACTGAAGGACTTAAGAGATCAGTTGAAA
GGCATTGAACGAAATATGGACGTTCAAGAGGTGCAATATACATTTGACCTACAGCTTGCC
CAAGAGGATGCAAAGAAGATGGCTGTTAAGGAAGAAAAATATGATCCAGGTTATGAGGCA
GCATATGGTGGTGCTTACGGAGAAAATCCATGCAGCAGTGAACCTTGTGGCTTCTCTTCA
AATGGGCTAATTGAGAGCGTGGAGTTAAGAGGAGAATCAGCTTTCAGTGGCATTCCTAAT
GGGCAGTGGATGACCCAGTCATTTACAGACCAAATTCCTTCCTTTAGTAATCACTGTGGA
ACACAAGAACAGGAAGAAGAAAGCCATGCTTAA
Protein Properties
Number of Residues 410
Molecular Weight 46053.0
Theoretical pI 6.79
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>G/T mismatch-specific thymine DNA glycosylase
MEAENAGSYSLQQAQAFYTFPFQQLMAEAPNMAVVNEQQMPEEVPAPAPAQEPVQEAPKG
RKRKPRTTEPKQPVEPKKPVESKKSGKSAKSKEKQEKITDTFKVKRKVDRFNGVSEAELL
TKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHT
LPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSK
EVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLK
GIERNMDVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCSSEPCGFSS
NGLIESVELRGESAFSGIPNGQWMTQSFTDQIPSFSNHCGTQEQEEESHA
GenBank ID Protein 23267188
UniProtKB/Swiss-Prot ID Q13569
UniProtKB/Swiss-Prot Entry Name TDG_HUMAN
PDB IDs Not Available
GenBank Gene ID AF545435
GeneCard ID TDG
GenAtlas ID TDG
HGNC ID HGNC:11700
References
General References Not Available