Cannabis Compound Database: Showing Protein Polyprenol reductase (CDBP04339)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP04339

Secondary Accession Numbers

Not Available

Name

Polyprenol reductase

Description

Not Available

Synonyms

3-oxo-5-alpha-steroid 4-dehydrogenase 3
S5AR 3
SR type 3
Steroid 5-alpha-reductase 2-like
Steroid 5-alpha-reductase 3

Gene Name

SRD5A3

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity, acting on the CH-CH group of donors

Specific Function

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).

GO Classification

Biological Process
protein glycosylation
dolichol-linked oligosaccharide biosynthetic process
dolichol metabolic process
polyprenol catabolic process
androgen biosynthetic process
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Component
intracellular part
cytoplasm
membrane part
intrinsic to membrane
integral to membrane
cell part
Function
oxidoreductase activity, acting on the ch-ch group of donors
catalytic activity
oxidoreductase activity
Molecular Function
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
3-oxo-5-alpha-steroid 4-dehydrogenase activity
cholestenone 5-alpha-reductase activity
Process
metabolic process
primary metabolic process
lipid metabolic process

Cellular Location

Endoplasmic reticulum membrane
Multi-pass membrane protein (Probable)

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein glycosylation	Not Available	Not Available
Steroid hormone biosynthesis	Not Available

Gene Properties

Chromosome Location

Locus

4q12

SNPs

SRD5A3

Gene Sequence

>957 bp
ATGGCTCCCTGGGCGGAGGCCGAGCACTCGGCGCTGAACCCGCTGCGCGCGGTGTGGCTC
ACGCTGACCGCCGCCTTCCTGCTGACCCTACTGCTGCAGCTCCTGCCGCCCGGCCTGCTC
CCGGGCTGCGCGATCTTCCAGGACCTGATCCGCTATGGGAAAACCAAGTGTGGGGAGCCG
TCGCGCCCCGCCGCCTGCCGAGCCTTTGATGTCCCCAAGAGATATTTTTCCCACTTTTAT
ATCATCTCAGTGCTGTGGAATGGCTTCCTGCTTTGGTGCCTTACTCAATCTCTGTTCCTG
GGAGCACCTTTTCCAAGCTGGCTTCATGGTTTGCTCAGAATTCTCGGGGCGGCACAGTTC
CAGGGAGGGGAGCTGGCACTGTCTGCATTCTTAGTGCTAGTATTTCTGTGGCTGCACAGC
TTACGAAGACTCTTCGAGTGCCTCTACGTCAGTGTCTTCTCCAATGTCATGATTCACGTC
GTGCAGTACTGTTTTGGACTTGTCTATTATGTCCTTGTTGGCCTAACTGTGCTGAGCCAA
GTGCCAATGGATGGCAGGAATGCCTACATAACAGGGAAAAATCTATTGATGCAAGCACGG
TGGTTCCATATTCTTGGGATGATGATGTTCATCTGGTCATCTGCCCATCAGTATAAGTGC
CATGTTATTCTCGGCAATCTCAGGAAAAATAAAGCAGGAGTGGTCATTCACTGTAACCAC
AGGATCCCATTTGGAGACTGGTTTGAATATGTTTCTTCCCCTAACTACTTAGCAGAGCTG
ATGATCTACGTTTCCATGGCCGTCACCTTTGGGTTCCACAACTTAACTTGGTGGCTAGTG
GTGACAAATGTCTTCTTTAATCAGGCCCTGTCTGCCTTTCTCAGCCACCAATTCTACAAA
AGCAAATTTGTCTCTTACCCGAAGCATAGGAAAGCTTTCCTACCATTTTTGTTTTAA

Protein Properties

Number of Residues

318

Molecular Weight

36521.005

Theoretical pI

9.391

Pfam Domain Function

Steroid_dh (PF02544 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Probable polyprenol reductase
MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP
SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF
QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ
VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH
RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK
SKFVSYPKHRKAFLPFLF

External Links

GenBank ID Protein

13375785

UniProtKB/Swiss-Prot ID

Q9H8P0

UniProtKB/Swiss-Prot Entry Name

PORED_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_024592.3

GeneCard ID