| Identification |
|---|
| HMDB Protein ID
| CDBP04334 |
| Secondary Accession Numbers
| Not Available |
| Name
| Methionine-R-sulfoxide reductase B3 |
| Description
| Not Available |
| Synonyms
|
- MsrB3
|
| Gene Name
| MSRB3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in peptide-methionine-(S)-S-oxide reductase activity |
| Specific Function
| Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
|
| GO Classification
|
| Biological Process |
| protein repair |
| Cellular Component |
| endoplasmic reticulum |
| mitochondrion |
| Function |
| oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
| catalytic activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| oxidoreductase activity |
| peptide-methionine-(s)-s-oxide reductase activity |
| Molecular Function |
| peptide-methionine (R)-S-oxide reductase activity |
| metal ion binding |
| zinc ion binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Isoform 2:Endoplasmic reticulum
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Methionine Metabolism |    |  | | Cystathionine Beta-Synthase Deficiency |    | Not Available | | Hypermethioninemia |    | Not Available | | S-Adenosylhomocysteine (SAH) Hydrolase Deficiency |    | Not Available | | Glycine N-methyltransferase Deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q14.3 |
| SNPs
| MSRB3 |
| Gene Sequence
|
>558 bp
ATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCC
TGTGGGCTTCCCTCAGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAG
CAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACC
GAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTT
GTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCAGGTTGGCCT
TCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGG
ATGCACAGGGTGGAAACAAGCTGCTCTCAGTGTGGTGCTCACCTTGGGCACATTTTTGAT
GATGGGCCTCGTCCAACTGGGAAAAGATACTGCATAAATTCGGCTGCCTTGTCTTTTACA
CCTGCGGATAGCAGTGGCACCGCCGAGGGAGGCAGTGGGGTCGCCAGCCCGGCCCAGGCA
GACAAAGCGGAGCTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 185 |
| Molecular Weight
| 20010.23 |
| Theoretical pI
| 7.152 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Methionine-R-sulfoxide reductase B3, mitochondrial
MSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGT
ESAFEGEYTHHKDPGIYKCVVCGTPLFKSETKFDSGSGWPSFHDVINSEAITFTDDFSYG
MHRVETSCSQCGAHLGHIFDDGPRPTGKRYCINSAALSFTPADSSGTAEGGSGVASPAQA
DKAEL
|
| External Links |
|---|
| GenBank ID Protein
| 158259629 |
| UniProtKB/Swiss-Prot ID
| Q8IXL7 |
| UniProtKB/Swiss-Prot Entry Name
| MSRB3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK293084 |
| GeneCard ID
| MSRB3 |
| GenAtlas ID
| MSRB3 |
| HGNC ID
| HGNC:27375 |
| References |
|---|
| General References
| Not Available |