| Identification |
|---|
| HMDB Protein ID
| CDBP04333 |
| Secondary Accession Numbers
| Not Available |
| Name
| Methionine-R-sulfoxide reductase B2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- MsrB2
|
| Gene Name
| MSRB2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in peptide-methionine-(S)-S-oxide reductase activity |
| Specific Function
| Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine (By similarity). Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.
|
| GO Classification
|
| Biological Process |
| protein repair |
| Cellular Component |
| mitochondrion |
| Function |
| oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
| catalytic activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| oxidoreductase activity |
| peptide-methionine-(s)-s-oxide reductase activity |
| Molecular Function |
| peptide-methionine (R)-S-oxide reductase activity |
| metal ion binding |
| sequence-specific DNA binding transcription factor activity |
| zinc ion binding |
| Process |
| oxidation reduction |
| metabolic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Methionine Metabolism |    |  | | Cystathionine Beta-Synthase Deficiency |    | Not Available | | Hypermethioninemia |    | Not Available | | S-Adenosylhomocysteine (SAH) Hydrolase Deficiency |    | Not Available | | Glycine N-methyltransferase Deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10p12 |
| SNPs
| MSRB2 |
| Gene Sequence
|
>549 bp
ATGGCGCGGCTCCTCTGGTTGCTCCGGGGCCTGACCCTCGGAACTGCGCCTCGGCGGGCG
GTGCGGGGCCAAGCGGGCGGCGGCGGGCCCGGCACCGGGCCGGGACTGGGGGAGGCAGGG
TCTCTTGCAACGTGTGAGCTGCCTCTTGCCAAGAGTGAGTGGCAAAAGAAACTAACCCCG
GAGCAGTTCTACGTCACAAGAGAAAAGGGAACGGAACCGCCTTTCAGTGGGATCTACCTG
AATAACAAGGAAGCAGGAATGTATCATTGCGTGTGCTGCGACAGTCCACTCTTCAGTTCT
GAGAAAAAGTACTGCTCTGGCACTGGGTGGCCTTCGTTTTCCGAGGCTCATGGTACGTCT
GGCTCTGATGAAAGCCACACAGGGATCCTGAGACGTCTGGATACCTCGTTAGGATCAGCT
CGCACAGAGGTTGTCTGCAAGCAGTGTGAAGCTCATCTAGGTCACGTGTTTCCTGATGGA
CCTGGGCCCAATGGTCAGAGGTTTTGCATCAACAGTGTGGCTTTGAAGTTCAAACCAAGG
AAACACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 182 |
| Molecular Weight
| 19536.055 |
| Theoretical pI
| 8.634 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Methionine-R-sulfoxide reductase B2, mitochondrial
MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLATCELPLAKSEWQKKLTP
EQFYVTREKGTEPPFSGIYLNNKEAGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAHGTS
GSDESHTGILRRLDTSLGSARTEVVCKQCEAHLGHVFPDGPGPNGQRFCINSVALKFKPR
KH
|
| External Links |
|---|
| GenBank ID Protein
| 5059062 |
| UniProtKB/Swiss-Prot ID
| Q9Y3D2 |
| UniProtKB/Swiss-Prot Entry Name
| MSRB2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF122004 |
| GeneCard ID
| MSRB2 |
| GenAtlas ID
| MSRB2 |
| HGNC ID
| HGNC:17061 |
| References |
|---|
| General References
| Not Available |