| Identification |
|---|
| HMDB Protein ID
| CDBP04330 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aflatoxin B1 aldehyde reductase member 4 |
| Description
| Not Available |
| Synonyms
|
- AFB1 aldehyde reductase 3
- AFB1-AR 3
- Aldoketoreductase 7-like
|
| Gene Name
| AKR7L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen |
| GO Classification
|
| Function |
| catalytic activity |
| oxidoreductase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36.13|1p35-p36.1 |
| SNPs
| AKR7L |
| Gene Sequence
|
>996 bp
ATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGG
CGCCGCATGGACGCGCCCACCAGCGCCGCAGTCACGCGCGCCTTCCTGGAGCGCGGCCAC
ACCGAGATAGACACGGCCTTCCTGTACAGCGACGGCCAGTCCGAGACCATCCTTGGCGGC
CTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCA
TGGATTGGGAACTCCCTGAAGCCTGACAGTGTCCGATCCCAGCTGGAGACGTCACTGAAG
CGGCTGCAGTGTCCCTGAGTGGACCTCTTCTATCTACATGCACCTGACCACAGCGCCCCG
GTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTT
GGCCTCTCCAACTATGCCGCCTGGGAAGTGGCCGAGATCTGTACCCTCTGCAAGAGCAAC
GGCTGGATCCTGCCCACTGTGTACCAGGGCATGTACAGCGCCACCACCCGGCAGGTGGAA
ACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTG
GCTGGGGGCCTGCTGACCGGCAAGTACAAGTATGAGGACAAGGACGGGAAACAGCCCGTG
GGCCGCTTCTTTGGGACTCAGTGGGCAGAGATCTACAGGAATCACTTCTGGAAGGAGCAC
CACTTCGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCT
CCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACAGCTGCAGGGTGCC
CACGGGGACGCGGTCATCCTGGGCATGTCCAGCCTGGAGCAGCTGGAGCAGAACTTGGCA
GCGGCAGAGGAAGGGCCCCTGGAGCCGGCTGTCGTGGACGCCTTTAATCAAGCCTGGCAT
TTGTTTGCCCACGAATGTCCCAACTACTTCATCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 331 |
| Molecular Weight
| 36963.5 |
| Theoretical pI
| 6.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Aflatoxin B1 aldehyde reductase member 4
MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGG
LGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAP
VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVE
TELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHFWKEH
HFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA
AAEEGPLEPAVVDAFNQAWHLFAHECPNYFI
|
| External Links |
|---|
| GenBank ID Protein
| 223718702 |
| UniProtKB/Swiss-Prot ID
| Q8NHP1 |
| UniProtKB/Swiss-Prot Entry Name
| ARK74_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_201252.3 |
| GeneCard ID
| AKR7L |
| GenAtlas ID
| AKR7L |
| HGNC ID
| HGNC:24056 |
| References |
|---|
| General References
| Not Available |