Showing Protein N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 (CDBP04328)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04328
Secondary Accession Numbers Not Available
Name N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
Description Not Available
Synonyms
  1. Beta-1,4-N-acetylgalactosaminyltransferase IV
  2. Beta4GalNAc-T4
  3. Beta4GalNAcT4
  4. NGalNAc-T1
Gene Name B4GALNT4
Protein Type Enzyme
Biological Properties
General Function Involved in transferase activity, transferring hexosyl groups
Specific Function Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.
GO Classification
Cellular Component
Golgi cisterna membrane
integral to membrane
Component
golgi membrane
membrane
cell part
organelle membrane
golgi cisterna membrane
Function
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
catalytic activity
transferase activity
Molecular Function
acetylgalactosaminyltransferase activity
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity
Cellular Location
  1. Single-pass type II membrane protein
  2. Golgi apparatus
  3. Golgi stack membrane
Pathways
Gene Properties
Chromosome Location 11
Locus 11p15.5
SNPs B4GALNT4
Gene Sequence 
>3120 bp
ATGCCGCGGCTCCCGGTGAAGAAGATCCGTAAGCAGATGAAGCTGCTGCTGCTGCTGCTG
CTGCTGAGCTGCGCCGCGTGGCTCACCTACGTGCACCTGGGCCTGGTGCGCCAGGGACGC
GCGCTGCGCCAGCGCCTGGGCTACGGGCGAGATGGTGAGAAGCTGACCAGTGAGACCGAC
GGCCGGGGGGTCCACGCTGCGCCATCCACACAGAGGGCTGAGGACTCCAGTGAGAGCCGT
GAAGAGGAGCAAGCGCCCGAAGGTCGGGACCTAGACATGCTGTTTCCTGGGGGGGCTGGG
AGGCTGCCACTGAACTTCACCCATCAGACACCCCCATGGCGGGAGGAGTACAAGGGGCAG
GTGAACCTGCACGTGTTTGAGGACTGGTGTGGGGGCGCCGTGGGCCACCTGAGGAGGAAC
CTGCACTTCCCGCTGTTCCCTCATACGCGCACCACCGTGAAGAAGTTGGCCGTGTCCCCC
AAGTGGAAGAACTATGGACTCCGTATTTTTGGTTTCATCCACCCGGCGAGGGACGGAGAC
GTCCAGTTTTCTGTGGCCTCAGACGACAACTCGGAGTTCTGGCTGAGTCTGGACGAGAGC
CCTGCTGCTGCCCAGCTTGTGGCCTTTGTGGGCAAGACTGGCTCCGAGTGGACAGCGCCT
GGAGAATTCACCAAGTTCAGCTCCCAGGTGTCCAAGCCCAGGCGGCTCATGGCCTCCCGG
AGGTACTACTTTGAGTTGCTGCACAAGCAGGACGACCGCGGCTCGGACCACGTGGAAGTG
GGCTGGCGAGCTTTCCTGCCCGGCCTGAAGTTCGAGGTCATCAGCTCTGCTCACATCTCC
CTGTACACAGATGAGTCAGCCTTGAAGATGGACCACGTGGCGCACGTCCCCCAGTCTCCA
GCCAGCCACGTGGGGGGGCGTCCGCCGCAGGAGGAGACCAGCGCAGACATGCTGCGGCCA
GATCCCAGGGATACCTTTTTCCTCACTCCACGCATGGAATCTTCGAGCCTGGAGAACGTG
CTGGAGCCCTGCGCCTACGCCCCCACCTACGTGGTCAAGGACTTCCCGATCGCCAGATAC
CAGGGCCTGCAATTTGTGTACCTGTCCTTCGTTTATCCCAACGACTACACTCGCCTCACC
CACATGGAGACGGACAACAAGTGCTTCTACCGCGAGTCTCCGCTGTATCTGGAGAGGTTT
GGGTTCTATAAATACATGAAGATGGACAAGGAGGAGGGGGATGAGGATGAAGAAGACGAG
GTGCAGCGCCGAGCCTTCCTCTTCCTCAACCCGGACGACTTCCTGGACGACGAGGACGAG
GGGGAGCTGCTCGACAGCCTGGAGCCCACCGAGGCGGCCCCGCCCAGGAGCGGCCCCCAG
TCCCCCGCCCCAGCAGCCCCCGCCCAGCCCGGAGCCACCCTCGCCCCGCCGACCCCTCCC
CGCCCCCGGGACGGGGGGACCCCCAGGCACTCCCGGGCCCTGAGCTGGGCCGCCAGGGCC
GCCCGCCCTTTGCCGCTCTTCTTGGGCCGAGCTCCGCCCCCGCGCCCTGCAGTGGAGCAG
CCGCCCCCAAAGGTGTACGTGACCAGGGTGCGGCCGGGACAGCGGGCATCCCCCCGGGCC
CCAGCGCCGCGTGCGCCCTGGCCGCCCTTCCCTGGCGTCTTCCTGCACCCCAGGCCTCTG
CCCAGAGTGCAGCTGCGGGCGCCCCCACGCCCACCCCGGCCCCACGGCCGCAGGACCGGC
GGCCCCCAGGCCACACAGCCGAGGCCCCCAGCCCGGGCGCAGGCCACCCAAGGGGGCCGG
GAGGGCCAGGCGCGCACGCTGGGACCTGCGGCGCCCACAGTGGACTCAAACTTGTCCTCC
GAAGCGCGGCCCGTGACCTCCTTCCTGAGCTTGTCCCAGGTGTCCGGGCCGCAGCTGCCC
GGGGAGGGCGAAGAGGAGGAGGAAGGGGAGGACGATGGGGCCCCGGGCGACGAGGCCGCG
TCGGAGGACAGCGAGGAGGCCGCGGGCCCGGCGCTCGGACGCTGGCGTGAGGACGCCATC
GACTGGCAGCGCACGTTCAGCGTGGGCGCCGTGGACTTCGAGCTGCTGCGCTCGGACTGG
AACGACCTGCGATGCAACGTTTCGGGGAACCTGCAGCTGCCGGAGGCGGAGGCCGTGGAC
GTGACCGCTCAGTACATGGAGCGGCTGAACGCGCGCCACGGCGGGCGCTTCGCGCTTCTG
CGCATCGTGAACGTGGAGAAGCGCCGGGACTCGGCGCGAGGGAGTCGCTTCCTGCTGGAG
CTGGAGCTGCAGGAGCGCGGGGGCGGCCGCCTGCGACTGTCCGAGTACGTCTTCCTGCGG
CTGCCGGGAGCCCGCGTAGGGGATGCAGACGGAGAAAGTCCCGAACCCGCTCCCGCCGCC
TCCGTGCGCCCCGACGGCCGCCCCGAGCTCTGCCGGCCACTGCGCCTGGCCTGGCGCCAG
GACGTGATGGTTCACTTCATCGTGCCAGTGAAAAACCAGGCACGGTGGGTGGCACAGTTC
CTGGCGGACATGGCTGCGCTGCACGCGCGCACCGGGGACTCGCGTTTCAGCGTCGTCCTG
GTGGATTTCGAGAGCGAGGATATGGACGTGGAGCGGGCCCTGCGCGCCGCGCGCCTGCCC
CGGTACCAGTACCTGAGACGAACCGGGAACTTCGAGCGCTCCGCCGGGCTGCAGGCGGGA
GTGGACGCGGTAGAGGACGCCAGCAGCATCGTGTTCCTCTGCGACCTGCACATCCACTTC
CCACCCAACATCCTGGACGGCATCCGCAAGCACTGCGTGGAGGGCAGGCTGGCCTTCGCG
CCCGTGGTCATGCGCCTGAGCTGCGGGAGCTCGCCCCGGGACCCCCACGGTTACTGGGAG
GTGAACGGCTTTGGCCTTTTTGGGATCTACAAGTCGGACTTTGACCGGGTTGGAGGAATG
AACACGGAGGAGTTCCGAGACCAGTGGGGGGGTGAAGACTGGGAGCTCCTGGACAGGGTC
CTGCAGGCAGGGCTGGAGGTGGAGCGGCTCCGACTGCGGAATTTCTATCACCACTACCAC
TCCAAGAGGGGCATGTGGAGCGTCCGCAGCAGGAAGGGCTCTCGCACGGGGGCGTCTTGA
Protein Properties
Number of Residues 1039
Molecular Weight 116512.09
Theoretical pI 6.975
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
MPRLPVKKIRKQMKLLLLLLLLSCAAWLTYVHLGLVRQGRALRQRLGYGRDGEKLTSETD
GRGVHAAPSTQRAEDSSESREEEQAPEGRDLDMLFPGGAGRLPLNFTHQTPPWREEYKGQ
VNLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVKKLAVSPKWKNYGLRIFGFIHPARDGD
VQFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEWTAPGEFTKFSSQVSKPRRLMASR
RYYFELLHKQDDRGSDHVEVGWRAFLPGLKFEVISSAHISLYTDESALKMDHVAHVPQSP
ASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPIARY
QGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDE
VQRRAFLFLNPDDFLDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPP
RPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRA
PAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGR
EGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAA
SEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAEAVD
VTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLR
LPGARVGDADGESPEPAPAASVRPDGRPELCRPLRLAWRQDVMVHFIVPVKNQARWVAQF
LADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRTGNFERSAGLQAG
VDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWE
VNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYH
SKRGMWSVRSRKGSRTGAS
GenBank ID Protein 40645106
UniProtKB/Swiss-Prot ID Q76KP1
UniProtKB/Swiss-Prot Entry Name B4GN4_HUMAN
PDB IDs Not Available
GenBank Gene ID AB089939
GeneCard ID B4GALNT4
GenAtlas ID B4GALNT4
HGNC ID HGNC:26315
References
General References Not Available