| Identification |
|---|
| HMDB Protein ID
| CDBP04316 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein phosphatase PGAM5, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Bcl-XL-binding protein v68
- Phosphoglycerate mutase family member 5
|
| Gene Name
| PGAM5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphoprotein phosphatase activity |
| Specific Function
| Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
|
| GO Classification
|
| Cellular Component |
| mitochondrial outer membrane |
| integral to membrane |
| Molecular Function |
| phosphoprotein phosphatase activity |
|
| Cellular Location
|
- Mitochondrion
- Membrane
- Mitochondrion outer membrane
- Single-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q24.33 |
| SNPs
| PGAM5 |
| Gene Sequence
|
>870 bp
ATGGCGTTCCGGCAGGCGCTGCAGCTGGCGGCCTGCGGGCTGGCCGGGGGCTCGGCCGCC
GTGCTCTTCTCGGCCGTGGCGGTAGGGAAGCCGCGCGCAGGCGGGGACGCGGAGCCACGC
CCGGCTGAGCCGCCGGCCTGGGCGGGGGGCGCGCGGCCGGGCCCCGGTGTCTGGGACCCC
AACTGGGACAGGCGAGAACCACTGTCTCTGATCAACGTGCGGAAGAGGAACGTGGAATCT
GGGGAAGAAGAGCTGGCGTCCAAGCTGGACCACTACAAAGCCAAGGCCACGCGGCACATC
TTCCTCATCAGGCATTCCCAGTACCACGTGGATGGCTCCCTGGAGAAGGACCGCACTCTG
ACCCCGCTGGGTCGGGAGCAGGCTGAACTCACTGGGCTCCGCCTGGCAAGCTTGGGGTTG
AAGTTTAATAAAATCGTCCATTCGTCTATGACGCGCGCCATAGAGACCACCGATATCATC
AGCCGGCACCTGCCAGGCGTCTGCAAAGTCAGCACAGATCTGCTGCGGGAAGGCGCCCCC
ATCGAGCCAGACCCGCCCGTGTCTCATTGGAAGCCGGAAGCTGTGCAGTATTACGAAGAC
GGAGCCCGGATCGAGGCCGCCTTCCGGAACTACATCCACCGCGCAGATGCCAGGCAGGAG
GAGGACAGTTACGAGATCTTCATCTGTCACGCCAACGTCATCCGCTACATCGTGTGCAGA
GCACTGCAGTTTCCTCCTGAAGGCTGGCTCCGGCTCTCCCTCAATAATGGCAGCATCACC
CACCTGGTGATCCGACCCAACGGCCGAGTTGCGCTCAGGACCCTCGGGGACACGGGGTTC
ATGCCTCCCGACAAGATCACTCGATCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 289 |
| Molecular Weight
| 32004.11 |
| Theoretical pI
| 8.679 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase PGAM5, mitochondrial
MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDAEPRPAEPPAWAGGARPGPGVWDP
NWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTL
TPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREGAP
IEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCR
ALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
|
| External Links |
|---|
| GenBank ID Protein
| 281604136 |
| UniProtKB/Swiss-Prot ID
| Q96HS1 |
| UniProtKB/Swiss-Prot Entry Name
| PGAM5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001170543.1 |
| GeneCard ID
| PGAM5 |
| GenAtlas ID
| PGAM5 |
| HGNC ID
| HGNC:28763 |
| References |
|---|
| General References
| Not Available |