| Identification |
|---|
| HMDB Protein ID
| CDBP04304 |
| Secondary Accession Numbers
| Not Available |
| Name
| Gastrotropin |
| Description
| Not Available |
| Synonyms
|
- Fatty acid-binding protein 6
- GT
- I-15P
- I-BABP
- ILBP
- Ileal lipid-binding protein
- Intestinal 15 kDa protein
- Intestinal bile acid-binding protein
|
| Gene Name
| FABP6 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis |
| GO Classification
|
| Function |
| binding |
| transporter activity |
| lipid binding |
| Process |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Isoform 2:Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q33.3-q34 |
| SNPs
| FABP6 |
| Gene Sequence
|
>387 bp
ATGGCTTTCACCGGCAAGTTCGAGATGGAGAGTGAGAAGAATTATGATGAGTTCATGAAG
CTCCTTGGGATCTCCAGCGATGTAATCGAAAAGGCCCGCAACTTCAAGATCGTCACGGAG
GTGCAGCAGGATGGGCAGGACTTCACTTGGTCCCAGCACTACTCCGGGGGCCACACCATG
ACCAACAAGTTCACTGTTGGCAAGGAAAGCAACATACAGACAATGGGGGGCAAGACGTTC
AAGGCCACTGTGCAGATGGAGGGCGGGAAGCTGGTGGTGAATTTCCCCAACTATCACCAG
ACCTCAGAGATCGTGGGTGACAAGCTGGTGGAGGTCTCCACCATCGGAGGCGTGACCTAT
GAGCGCGTGAGCAAGAGACTGGCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 128 |
| Molecular Weight
| 14371.2 |
| Theoretical pI
| 6.81 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Gastrotropin
MAFTGKFEMESEKNYDEFMKLLGISSDVIEKARNFKIVTEVQQDGQDFTWSQHYSGGHTM
TNKFTVGKESNIQTMGGKTFKATVQMEGGKLVVNFPNYHQTSEIVGDKLVEVSTIGGVTY
ERVSKRLA
|
| External Links |
|---|
| GenBank ID Protein
| 4557583 |
| UniProtKB/Swiss-Prot ID
| P51161 |
| UniProtKB/Swiss-Prot Entry Name
| FABP6_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001445.2 |
| GeneCard ID
| FABP6 |
| GenAtlas ID
| FABP6 |
| HGNC ID
| HGNC:3561 |
| References |
|---|
| General References
| Not Available |