Cannabis Compound Database: Showing Protein Y+L amino acid transporter 2 (CDBP04290)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP04290

Secondary Accession Numbers

Not Available

Name

Y+L amino acid transporter 2

Description

Not Available

Synonyms

Cationic amino acid transporter, y+ system
Solute carrier family 7 member 6
Y+LAT2
y(+)L-type amino acid transporter 2
y+LAT-2

Gene Name

SLC7A6

Protein Type

Transporter

Biological Properties

General Function

Involved in transport

Specific Function

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells

GO Classification

Component
membrane
cell part
Function
active transmembrane transporter activity
transmembrane transporter activity
amine transmembrane transporter activity
amino acid transmembrane transporter activity
transporter activity
Process
establishment of localization
transport
amine transport
amino acid transport
transmembrane transport

Cellular Location

Multi-pass membrane protein
Basolateral cell membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Kidney Function		Not Available
Glucose Transporter Defect (SGLT2)		Not Available
Hartnup Disorder		Not Available
Iminoglycinuria		Not Available
Lysinuric Protein Intolerance		Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

16q22.1

SNPs

SLC7A6

Gene Sequence

>1548 bp
ATGGAAGCCAGGGAGCCTGGGAGGCCCACACCCACCTACCATCTTGTCCCTAACACCAGC
CAGTCCCAGGTGGAAGAAGATGTCAGCTCGCCACCTCAAAGGTCCTCCGAAACTATGCAG
CTGAAGAAGGAGATCTCCCTGCTGAATGGGGTCAGCCTGGTGGTGGGCAACATGATCGGC
TCAGGGATCTTTGTCTCACCCAAGGGTGTGCTGGTACACACTGCCTCCTATGGGATGTCA
CTGATTGTGTGGGCCATTGGTGGGCTCTTCTCTGTTGTGGGTGCCCTTTGTTATGCAGAG
CTGGGGACCACCATCACCAAGTCGGGAGCCAGCTACGCTTATATTCTAGAGGCCTTTGGG
GGCTTCATTGCCTTCATCCGCCTGTGGGTCTCACTGCTAGTTGTTGAGCCCACCGGTCAG
GCCATCATCGCCATCACCTTTGCCAACTACATCATCCAGCCGTCCTTCCCCAGCTGTGAT
CCCCCATACCTGGCCTGCCGTCTCCTGGCTGCTGCTTGCATATGTCTGCTGACATTTGTG
AACTGTGCCTATGTCAAGTGGGGCACACGTGTGCAGGACACGTTCACTTACGCCAAGGTC
GTAGCGCTCATTGCCATCATTGTCATGGGCCTTGTTAAACTGTGCCAGGGACACTCTGAG
CACTTTCAGGACGCCTTTGAGGGTTCCTCCTGGGACATGGGAAACCTCTCTCTTGCCCTC
TACTCTGCCCTCTTCTCTTACTCAGGTTGGGACACCCTTAATTTTGTAACAGAAGAAATC
AAAAACCCAGAAAGAAATTTGCCCTTGGCCATTGGGATTTCTATGCCAATTGTGACGCTC
ATCTACATCCTGACCAATGTGGCCTATTACACAGTGCTGAACATTTCAGATGTCCTTAGC
AGTGATGCTGTGGCTGTGACATTTGCTGACCAGACGTTTGGCATGTTCAGCTGGACCATC
CCCATTGCTGTTGCCCTGTCCTGCTTTGGGGGCCTCAATGCATCCATCTTTGCTTCATCA
AGGTTGTTCTTCGTGGGCTCCCGGGAGGGCCACCTACCGGACCTTCTGTCCATGATCCAC
ATTGAGCGTTTTACACCTATCCCTGCTTTACTGTTCAATTGCACCATGGCACTCATCTAC
CTCATCGTGGAGGATGTTTTCCAGCTTATCAACTACTTCAGCTTCAGCTACTGGTTCTTC
GTGGGCCTGTCTGTTGTTGGACAGCTCTACCTCCGCTGGAAGGAGCCCAAGCGGCCCCGG
CCTCTCAAGCTGAGCGTGTTTTTCCCCATCGTGTTCTGCATATGCTCCGTGTTTCTGGTG
ATAGTGCCCCTCTTCACTGACACCATTAATTCCCTCATTGGCATCGGGATTGCCCTTTCT
GGAGTCCCTTTCTACTTCATGGGTGTTTACCTGCCAGAGTCCCGGAGGCCATTGTTTATT
CGGAATGTCCTGGCTGCTATCACCAGAGGCACCCAGCAGCTTTGCTTTTGTGTCCTGACT
GAGCTTGATGTAGCCGAAGAAAAAAAGGATGAGAGGAAAACTGACTAG

Protein Properties

Number of Residues

515

Molecular Weight

56826.9

Theoretical pI

5.69

Pfam Domain Function

AA_permease (PF00324 )

Signals

["None"]

Transmembrane Regions

["45-65", "79-99", "115-135", "168-188", "195-215", "236-256", "267-287", "312-332", "364-384", "386-406", "426-446", "452-472"]

Protein Sequence

>Y+L amino acid transporter 2
MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIG
SGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFG
GFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFV
NCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLAL
YSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLS
SDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIH
IERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPR
PLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFI
RNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD

External Links

GenBank ID Protein

20381372

UniProtKB/Swiss-Prot ID

Q92536

UniProtKB/Swiss-Prot Entry Name

YLAT2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

BC028216

GeneCard ID