| Identification |
|---|
| HMDB Protein ID
| CDBP04288 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sorbin and SH3 domain-containing protein 2 |
| Description
| Not Available |
| Synonyms
|
- Arg/Abl-interacting protein 2
- ArgBP2
- Sorbin
|
| Gene Name
| SORBS2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| ion binding |
|
| Cellular Location
|
- Cytoplasm
- perinuclear region
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q35.1 |
| SNPs
| SORBS2 |
| Gene Sequence
|
>3303 bp
ATGAGTTACTATCAGAGGCCGTTTTCCCCCTCGGCATATTCTCTCCCAGCCTCACTCAAC
TCCAGCATTGTCATGCAGCACGGCACATCCCTCGATTCCACAGACACATATCCCCAGCAT
GCGCAGTCTCTGGATGGCACCACCAGCAGCTCTATCCCCCTGTACCGATCCTCAGAGGAA
GAGAAGAGAGTGACAGTCATCAAAGCCCCGCATTACCCAGGGATCGGGCCCGTGGATGAA
TCCGGAATCCCCACAGCAATTAGAACGACAGTCGACCGGCCCAAGGACTGGTACAAGACG
ATGTTTAAGCAAATTCACATGGTGCACAAGCCGGATGATGACACAGACATGTATAATACT
CCTTATACATACAATGCAGGTCTGTACAACCCACCCTACAGTGCTCAGTCACACCCTGCT
GCAAAGACCCAAACCTACAGACCTCTTTCCAAAAGCCACTCCGACAACAGCCCCAATGCC
TTTAAGGATGCGTCCTCCCCAGTGCCTCCCCCACATGTTCCACCTCCAGTCCCGCCGCTT
CGACCAAGAGATCGGTCTTCAACAGAAAAGCATGACTGGGATCCTCCAGACAGAAAAGTG
GACACAAGAAAATTTCGGTCTGAGCCAAGGAGTATTTTTGAATATGAACCTGGCAAGTCA
TCAATTCTTCAGCATGAAAGACCAGCCTCCTTGTATCAGTCCTCTATAGACAGAAGCCTG
GAAAGACCCATGAGTTCTGCAAGCATGGCCAGTGACTTCAGGAAGCGGAGGAAGAGCGAG
CCTGCAGTGGGTCCACCACGGGGCTTGGGAGATCAAAGTGCGAGCAGGACTAGCCCAGGC
CGAGTGGACCTCCCAGGATCAAGCACCACTCTTACAAAGTCTTTCACTAGCTCTTCTCCT
TCTTCCCCATCAAGAGCAAAAGGTGGGGATGATAGCAAAATATGTCCATCCCTTTGCAGT
TACTCAGGGCTCAACGGCAACCCCTCCAGTGAGTTAGATTACTGTAGCACTTACAGACAG
CACTTGGATGTCCCTCGGGACTCACCAAGAGCCATTAGTTTCAAGAACGGCTGGCAAATG
GCCCGGCAAAACGCAGAAATCTGGAGCAGCACGGAAGAAACCGTCTCTCCCAAAATCAAA
TCCCGGAGCTGTGACGATCTCCTAAACGACGACTGCGATAGCTTCCCGGACCCGAAAGTC
AAGTCGGAAAGCATGGGCTCCCTGTTATGTGAGGAGGACTCCAAGGAGAGCTGCCCCATG
GCGTGGGGGTCCCCCTACGTCCCGGAGGTTCGCAGTAACGGCAGATCAAGGATCAGACAC
AGGTCAGCCCGCAACGCCCCGGGGTTCCTGAAGATGTACAAGAAAATGCACCGCATCAAC
CGCAAGGACCTGATGAACTCCGAGGTGATCTGCTCCGTGAAGTCCAGGATTCTGCAGTAC
GAGAGCGAGCAGCAGCACAAGGACCTGCTGCGCGCCTGGAGCCAGTGCTCCACGGAGGAG
GTGCCCCGGGACATGGTGCCCACACGCATCTCCGAATTCGAAAAGCTGATCCAGAAGTCC
AAATCCATGCCAAATTTAGGGGATGACATGCTGTCTCCCGTAACCCTAGAACCACCGCAA
AATGGCCTATGTCCCAAGAGGCGGTTTTCCATTGAGTATTTGCTGGAGGAAGAAAATCAA
AGCGGCCCCCCCGCTCGGGGCCGGCGAGGCTGCCAGTCTAACGCCCTGGTGCCCATTCAC
ATTGAAGTCACCAGCGATGAGCAGCCCCGAGCACACGTGGAGTTTTCCGACAGCGACCAG
GACGGGGTTGTGTCCGACCACAGTGACTACATTCACCTAGAGGGGTCATCCTTCTGCAGT
GAAAGTGACTTTGATCACTTTTCCTTCACATCCTCCGAAAGCTTTTACGGATCCAGCCAC
CACCACCACCATCACCACCACCACCACCACCGCCACCTCATCAGCTCCTGCAAAGGCAGG
TGCCCGGCCTCCTACACTCGATTTACCACAATGTTAAAACACGAAAGAGCCAGACACGAA
AACACCGAGGAGCCCAGAAGGCAAGAAATGGACCCTGGCCTTTCTAAACTTGCTTTTCTA
GTCAGTCCTGTGCCTTTCCGGAGGAAAAAAAATTCGGCTCCTAAGAAACAGACTGAAAAG
GCAAAATGTAAAGCATCTGTGTTTGAGGCTCTGGACTCTGCCCTTAAAGACATCTGTGAC
CAAATTAAAGCTGAAAAGAAAAGGGGGAGCTTGCCGGACAACAGCATCCTGCACCGCCTC
ATCAGTGAGCTGCTGCCAGATGTTCCCGAGAGGAACTCATCCCTGAGAGCGCTGAGGAGG
AGCCCCCTGCACCAGCCTCTCCACCCACTGCCTCCCGATGGTGCTATTCATTGTCCACCC
TACCAGAATGACTGCGGGAGAATGCCCCGCAGTGCCTCTTTCCAAGACGTGGACACAGCC
AACAGCAGCTGCCACCACCAAGACCGTGGCGGTGCACTCCAAGACCGTGAGTCCCCTAGA
AGTTACTCATCCACTTTGACTGACATGGGGAGAAGTGCACCAAGGGAAAGAAGAGGAACT
CCAGAAAAAGAGAAATTGCCTGCAAAAGCTGTTTATGATTTTAAGGCTCAGACATCTAAG
GAGTTGTCATTTAAGAAAGGAGATACTGTCTACATCCTCAGGAAAATTGATCAAAATTGG
TATGAGGGAGAACACCACGGGAGAGTGGGCATCTTCCCGATCTCATACGTAGAGAAACTC
ACACCTCCTGAGAAAGCACAGCCTGCAAGACCACCTCCGCCAGCCCAGCCCGGAGAAATC
GGAGAAGCTATAGCCAAATACAACTTCAACGCAGACACAAATGTGGAGCTGTCACTGAGA
AAGGGAGATAGAGTTATTCTTCTTAAAAGAGTTGATCAAAACTGGTATGAAGGTAAAATC
CCAGGAACCAACAGACAAGGCATCTTCCCTGTTTCCTATGTGGAGGTCGTCAAGAAGAAC
ACAAAAGGTGCTGAGGACTACCCTGACCCTCCAATACCCCACAGCTATTCTAGTGATAGG
ATTCACAGCTTGAGCTCAAATAAGCCACAGCGTCCTGTGTTTACTCATGAAAATATTCAA
GGTGGGGGGGAACCGTTTCAGGCTCTGTATAACTATACTCCCAGGAATGAAGATGAGCTG
GAGCTCAGAGAAAGTGATGTCATTGATGTCATGGAAAAGTGTGATGACGGCTGGTTTGTG
GGGACCTCAAGAAGAACCAAATTCTTTGGTACTTTCCCCGGAAACTACGTCAAGAGGCTG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 1100 |
| Molecular Weight
| 124106.3 |
| Theoretical pI
| 8.42 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sorbin and SH3 domain-containing protein 2
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL
ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP
SSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQM
ARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPM
AWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQY
ESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQ
NGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQ
DGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGR
CPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEK
AKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRR
SPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPR
SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW
YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR
KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR
IHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFV
GTSRRTKFFGTFPGNYVKRL
|
| External Links |
|---|
| GenBank ID Protein
| 10947118 |
| UniProtKB/Swiss-Prot ID
| O94875 |
| UniProtKB/Swiss-Prot Entry Name
| SRBS2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_021069.4 |
| GeneCard ID
| SORBS2 |
| GenAtlas ID
| SORBS2 |
| HGNC ID
| HGNC:24098 |
| References |
|---|
| General References
| Not Available |