| Identification |
|---|
| HMDB Protein ID
| CDBP04277 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium channel subunit beta-4 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SCN4B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated sodium channel activity |
| Specific Function
| Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q23.3 |
| SNPs
| SCN4B |
| Gene Sequence
|
>687 bp
ATGCCCGGGGCTGGGGACGGAGGCAAAGCCCCGGCGAGATGGCTGGGCACTGGGCTTTTG
GGCCTCTTCCTGCTCCCCGTAACCCTGTCGCTGGAGGTGTCTGTGGGAAAGGCCACCGAC
ATCTACGCTGTCAATGGCACGGAGATCCTGCTGCCCTGCACCTTCTCCAGCTGCTTTGGC
TTCGAGGACCTCCACTTCCGGTGGACCTACAACAGCAGTGACGCATTCAAGATTCTCATA
GAGGGGACTGTGAAGAATGAGAAGTCTGACCCCAAGGTGACGTTGAAAGACGATGACCGC
ATCACTCTGGTAGGCTCTACTAAGGAGAAGATGAACAACATTTCCATTGTGCTGAGGGAC
CTGGAGTTCAGCGACACGGGCAAATACACCTGCCATGTGAAGAACCCCAAGGAGAATAAT
CTCCAGCACCACGCCACCATCTTCCTCCAAGTCGTTGATAGACTGGAAGAAGTGGACAAC
ACAGTGACACTCATCATCCTGGCTGTCGTGGGCGGGGTCATCGGGCTCCTCATCCTCATC
CTGCTGATCAAGAAACTCATCATCTTCATCCTGAAGAAGACTCGGGAGAAGAAGAAGGAG
TGTCTCGTGAGCTCCTCGGGGAATGACAACACGGAGAACGGCTTGCCTGGCTCCAAGGCA
GAGGAGAAACCACCTTCAAAAGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 228 |
| Molecular Weight
| 24968.8 |
| Theoretical pI
| 7.45 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sodium channel subunit beta-4
MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFG
FEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRD
LEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILI
LLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV
|
| External Links |
|---|
| GenBank ID Protein
| 27465047 |
| UniProtKB/Swiss-Prot ID
| Q8IWT1 |
| UniProtKB/Swiss-Prot Entry Name
| SCN4B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY149967 |
| GeneCard ID
| SCN4B |
| GenAtlas ID
| SCN4B |
| HGNC ID
| HGNC:10592 |
| References |
|---|
| General References
| Not Available |