| Identification |
|---|
| HMDB Protein ID
| CDBP04275 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium channel subunit beta-3 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SCN3B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated sodium channel activity |
| Specific Function
| Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q23.3 |
| SNPs
| SCN3B |
| Gene Sequence
|
>648 bp
ATGCCTGCCTTCAATAGATTGTTTCCCCTGGCTTCTCTCGTGCTTATCTACTGGGTCAGT
GTCTGCTTCCCTGTGTGTGTGGAAGTGCCCTCGGAGACGGAGGCCGTGCAGGGCAACCCC
ATGAAGCTGCGCTGCATCTCCTGCATGAAGAGAGAGGAGGTGGAGGCCACCACGGTGGTG
GAATGGTTCTACAGGCCCGAGGGCGGTAAAGATTTCCTTATTTACGAGTATCGGAATGGC
CACCAGGAGGTGGAGAGCCCCTTTCAGGGGCGCCTGCAGTGGAATGGCAGCAAGGACCTG
CAGGACGTGTCCATCACTGTGCTCAACGTCACTCTGAACGACTCTGGCCTCTACACCTGC
AATGTGTCCCGGGAGTTTGAGTTTGAGGCGCATCGGCCCTTTGTGAAGACGACGCGGCTG
ATCCCCCTAAGAGTCACCGAGGAGGCTGGAGAGGACTTCACCTCTGTGGTCTCAGAAATC
ATGATGTACATCCTTCTGGTCTTCCTCACCCTGTGGCTGCTCATCGAGATGATATATTGC
TACAGAAAGGTCTCAAAAGCCGAAGAGGCAGCCCAAGAAAACGCGTCTGACTACCTTGCC
ATCCCATCTGAGAACAAGGAGAACTCTGCGGTACCAGTGGAGGAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 215 |
| Molecular Weight
| 24702.1 |
| Theoretical pI
| 4.35 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sodium channel subunit beta-3
MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
EWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTC
NVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYC
YRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
|
| External Links |
|---|
| GenBank ID Protein
| 7160975 |
| UniProtKB/Swiss-Prot ID
| Q9NY72 |
| UniProtKB/Swiss-Prot Entry Name
| SCN3B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ243396 |
| GeneCard ID
| SCN3B |
| GenAtlas ID
| SCN3B |
| HGNC ID
| HGNC:20665 |
| References |
|---|
| General References
| Not Available |