| Identification |
|---|
| HMDB Protein ID
| CDBP04273 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium channel subunit beta-2 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SCN2B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated sodium channel activity |
| Specific Function
| Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier |
| GO Classification
|
| Component |
| membrane |
| cell part |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q23 |
| SNPs
| SCN2B |
| Gene Sequence
|
>648 bp
ATGCAAAGAGATGCCTGGTTACTTCGCCCTGCCTTCAGCCTCAACGGGCTCAGTCTCTTT
TTCTCTTTGGTGCCACCAGGACGGAGCATGGAGGTCACAGTACCTGCCACCCTCAACGTC
CTCAATGGCTCTGACGCCCGCCAGCCCTGCACCTTCAACTCCTGCTACACAGTGAACCAC
AAACAGTTCTCCCTGAACTGGAGTTACCAGGAGTGCAACAACTGCTCTGAGGAGATGTTC
CTCCAGTTCCGCATGAAGATCATTAACCTGAAGCTGGAGCGGTTTCAAGACCGCGTGGAG
TTCTCAGGGAACCCCAGCAAGTACGATGTGTCGGTGATGCTGAGAAACGTGCAGCCGGAG
GATGAGGGGATTTACAACTGCTACATCATGAACCCCCCTGACCGCCACCGTGGCCATGGC
AAGATCCATCTGCAGGTCCTCATGGAAGAGCCCCCTGAGCGGGACTCCACGGTGGCCGTG
ATTGTGGGTGCCTCCGTCGGGGGCTTCCTGGCTGTGGTCATCTTGGTGCTGACGGCGGTC
AAGTGTGTGAGGAGAAAAAAAGAGCAGAAGCTGAGCACAGATGACCTGAAGACCGAGGAG
GAGGGCAAGACGGACGGTGAAGGCAACCCGGATGATGGCGCCAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 215 |
| Molecular Weight
| 24325.7 |
| Theoretical pI
| 6.35 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sodium channel subunit beta-2
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNH
KQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPE
DEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVV
KCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK
|
| External Links |
|---|
| GenBank ID Protein
| 3309111 |
| UniProtKB/Swiss-Prot ID
| O60939 |
| UniProtKB/Swiss-Prot Entry Name
| SCN2B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF007783 |
| GeneCard ID
| SCN2B |
| GenAtlas ID
| SCN2B |
| HGNC ID
| HGNC:10589 |
| References |
|---|
| General References
| Not Available |