| Identification |
|---|
| HMDB Protein ID
| CDBP04265 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium-dependent neutral amino acid transporter B(0)AT2 |
| Description
| Not Available |
| Synonyms
|
- Orphan transporter v7-3
- Solute carrier family 6 member 15
- Sodium- and chloride-dependent neurotransmitter transporter NTT73
- Sodium-coupled branched-chain amino-acid transporter 1
- Transporter v7-3
|
| Gene Name
| SLC6A15 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in neurotransmitter:sodium symporter activity |
| Specific Function
| Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
|
| GO Classification
|
| Biological Process |
| proline transport |
| transmembrane transport |
| leucine transport |
| Cellular Component |
| plasma membrane |
| integral to membrane |
| integral to plasma membrane |
| Component |
| integral to plasma membrane |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| neurotransmitter transporter activity |
| neurotransmitter:sodium symporter activity |
| transmembrane transporter activity |
| transporter activity |
| Molecular Function |
| neurotransmitter transporter activity |
| proline:sodium symporter activity |
| neurotransmitter:sodium symporter activity |
| Process |
| establishment of localization |
| transport |
| neurotransmitter transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q21.3 |
| SNPs
| SLC6A15 |
| Gene Sequence
|
>2193 bp
ATGCCCAAAAATAGCAAGGTGGTAAAAAGAGAATTAGATGATGATGTTACTGAGTCTGTC
AAAGACCTTCTTTCCAATGAAGACGCAGCTGATGATGCTTTTAAGACAAGTGAACTAATT
GTTGATGGCCAGGAAGAGAAAGATACAGATGTTGAAGAAGGATCTGAAGTCGAAGATGAA
AGACCAGCTTGGAACAGTAAACTACAATACATCCTGGCCCAAGTTGGATTTTCTGTAGGT
TTAGGAAATGTGTGGCGATTTCCATACCTATGTCAGAAGAATGGGGGCGGTGCATATCTT
TTACCATATTTAATACTACTTATGGTAATAGGTATTCCCCTTTTTTTCTTGGAACTCTCT
GTGGGTCAAAGAATTCGGCGAGGCAGCATTGGTGTATGGAATTACATAAGCCCTAAACTG
GGCGGGATTGGATTTGCAAGTTGTGTAGTGTGCTATTTTGTAGCTCTCTACTACAACGTC
ATCATTGGCTGGAGTTTGTTTTATTTTTCTCAGTCTTTTCAGCAACCCCTGCCTTGGGAT
CAGTGTCCTTTGGTGAAAAATGCTTCACACACTTTTGTAGAACCAGAATGTGAACAAAGT
TCTGCCACCACCTATTACTGGTACAGGGAAGCACTGAATATTTCAAGTTCCATTTCTGAA
AGTGGGGGCTTAAACTGGAAGATGACCATCTGCTTGTTGGCTGCCTGGGTCATGGTTTGC
TTGGCTATGATCAAAGGCATTCAGTCTTCTGGAAAAATCATATATTTTAGTTCTCTGTTT
CCATATGTGGTACTTATTTGCTTCCTCATCAGAGCATTCCTTTTAAATGGTTCAATTGAT
GGCATTCGCCACATGTTTACCCCTAAGCTTGAAATAATGCTGGAGCCCAAGGTCTGGAGA
GAAGCTGCTACTCAAGTGTTCTTTGCCTTAGGTCTGGGATTTGGTGGTGTCATTGCCTTT
TCAAGCTACAACAAGAGAGACAACAACTGCCACTTTGATGCTGTCCTGGTGTCCTTCATC
AATTTTTTCACTTCTGTCCTGGCAACATTGGTGGTGTTTGCAGTTCTGGGCTTCAAAGCA
AATGTCATAAATGAGAAATGCATTACACAAAATTCAGAGACGATCATGAAATTTTTGAAA
ATGGGGAACATTAGTCAGGATATTATTCCCCATCATATCAACCTTTCAACTGTTACTGCA
GAAGATTATCATTTAGTTTATGACATCATTCAAAAAGTGAAAGAAGAAGAGTTTCCTGCT
CTTCATCTCAATTCCTGTAAAATTGAAGAAGAGCTAAATAAAGCTGTTCAGGGGACCGGC
TTAGCTTTTATTGCCTTTACAGAAGCGATGACACATTTTCCTGCATCTCCCTTCTGGTCA
GTGATGTTTTTCCTCATGCTGGTCAATCTAGGCCTTGGCAGTATGTTTGGAACCATTGAA
GGGATTGTCACGCCTATTGTGGACACTTTCAAAGTGAGGAAAGAAATTCTTACTGTTATC
TGTTGTCTTCTGGCATTTTGTATTGGCCTGATATTTGTGCAACGCTCTGGAAATTACTTT
GTTACAATGTTTGATGATTATTCTGCTACACTGCCTCTGCTAATTGTAGTCATTTTGGAG
AATATTGCTGTATGCTTTGTTTATGGCATAGATAAGTTTATGGAAGACCTAAAAGATATG
CTGGGCTTTGCTCCCAGCAGATATTACTACTATATGTGGAAATATATTTCTCCTCTAATG
CTATTATCATTGCTAATAGCTAGTGTTGTGAATATGGGATTAAGTCCTCCTGGCTATAAC
GCATGGATTGAAGATAAGGCATCTGAAGAATTTCTGAGCTATCCAACATGGGGACTGGTT
GTTTGTGTCTCTCTGGTTGTCTTTGCAATACTCCCAGTCCCTGTAGTTTTCATTGTTCGT
CGCTTCAACCTTATAGATGATAGTTCTGGTAATTTAGCATCTGTGACCTATAAGAGAGGA
AGGGTCCTGAAAGAGCCTGTGAACTTAGAGGGCGATGATACAAGCCTCATTCACGGAAAA
ATACCGAGCGAGATGCCATCTCCAAATTTTGGTAAAAATATTTATCGAAAACAGAGTGGA
TCCCCAACTCTGGATACTGCTCCCAATGGACGGTATGGAATAGGGTACTTGATGGCAGAT
ATTATGCCAGATATGCCAGAATCTGATTTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 730 |
| Molecular Weight
| 69885.24 |
| Theoretical pI
| 6.007 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Orphan sodium- and chloride-dependent neurotransmitter transporter NTT73
MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE
RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS
VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD
QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC
LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR
EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA
NVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPA
LHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIE
GIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE
NIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYN
AWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRG
RVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMAD
IMPDMPESDL
|
| External Links |
|---|
| GenBank ID Protein
| 11907841 |
| UniProtKB/Swiss-Prot ID
| Q9H2J7 |
| UniProtKB/Swiss-Prot Entry Name
| S6A15_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF265577 |
| GeneCard ID
| SLC6A15 |
| GenAtlas ID
| SLC6A15 |
| HGNC ID
| HGNC:13621 |
| References |
|---|
| General References
| Not Available |