Cannabis Compound Database: Showing Protein tRNA (guanine-N(7)-)-methyltransferase (CDBP04239)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP04239

Secondary Accession Numbers

Not Available

Name

tRNA (guanine-N(7)-)-methyltransferase

Description

Not Available

Synonyms

Methyltransferase-like protein 1
tRNA(m7G46)-methyltransferase
tRNA (guanine(46)-N(7))-methyltransferase

Gene Name

METTL1

Protein Type

Enzyme

Biological Properties

General Function

Involved in tRNA (guanine-N7-)-methyltransferase activity

Specific Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

GO Classification

Cellular Component
nucleus
cytoplasm
Function
catalytic activity
transferase activity
rna methyltransferase activity
trna methyltransferase activity
trna (guanine) methyltransferase activity
trna (guanine-n7-)-methyltransferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Molecular Function
tRNA (guanine-N7-)-methyltransferase activity
tRNA binding
Process
macromolecule metabolic process
cellular macromolecule metabolic process
trna modification
rna metabolic process
ncrna metabolic process
trna metabolic process
trna processing
metabolic process

Cellular Location

Nucleus

Pathways

Name	SMPDB/Pathwhiz	KEGG
N(7)-methylguanine-tRNA biosynthesis	Not Available	Not Available

Gene Properties

Chromosome Location

Locus

12q13

SNPs

METTL1

Gene Sequence

>831 bp
ATGGCAGCCGAGACTCGGAACGTGGCCGGAGCAGAGGCCCCACCGCCCCAGAAGCGCTAC
TACCGGCAACGTGCTCACTCCAACCCCATGGCGGACCACACGCTGCGCTACCCTGTGAAG
CCAGAGGAGATGGACTGGTCTGAGCTATACCCAGAGTTCTTCGCTCCACTCACTCAAAAT
CAGAGCCACGATGACCCAAAGGATAAGAAAGAAAAGAGAGCTCAGGCCCAAGTGGAGTTT
GCAGACATAGGCTGTGGCTATGGTGGCCTGTTAGTGGAACTGTCACCGCTGTTCCCAGAC
ACACTTATTCTGGGTCTGGAGATCCGGGTGAAGGTCTCAGACTATGTACAAGACCGGATT
CGGGCCCTACGCGCAGCTCCTGCAGGTGGCTTCCAGAACATCGCCTGTCTCCGTAGCAAT
GCCATGAAGCACCTTCCTAACTTCTTCTACAAGGGCCAGCTGACAAAGATGTTCTTCCTC
TTCCCCGACCCACATTTCAAGCGGACAAAGCACAAGTGGCGAATCATCAGTCCCACCCTG
CTAGCAGAATATGCCTACGTGCTAAGAGTTGGGGGGCTGGTGTATACCATAACCGATGTG
CTGGAGCTACACGACTGGATGTGCACTCATTTCGAAGAGCACCCACTGTTTGAGCGTGTG
CCTCTGGAGGACCTGAGTGAAGACCCCGTTGTGGGACATCTAGGCACCTCAACTGAGGAG
GGGAAGAAAGTTCTACGTAATGGAGGGAAGAATTTCCCAGCCATCTTCCGAAGAATACAA
GATCCCGTCCTCCAGGCAGTGACCTCCCAAACCAGCCTGCCTGGTCACTGA

Protein Properties

Number of Residues

276

Molecular Weight

31470.775

Theoretical pI

7.634

Pfam Domain Function

Methyltransf_4 (PF02390 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>tRNA (guanine-N(7)-)-methyltransferase
MAAETRNVAGAEAPPPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQN
QSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRI
RALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQLTKMFFLFPDPHFKRTKHKWRIISPTL
LAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEE
GKKVLRNGGKNFPAIFRRIQDPVLQAVTSQTSLPGH

External Links

GenBank ID Protein

189054580

UniProtKB/Swiss-Prot ID

Q9UBP6

UniProtKB/Swiss-Prot Entry Name

TRMB_HUMAN

PDB IDs