| Identification |
|---|
| HMDB Protein ID
| CDBP04232 |
| Secondary Accession Numbers
| Not Available |
| Name
| Probable methyltransferase TARBP1 |
| Description
| Not Available |
| Synonyms
|
- TAR RNA-binding protein 1
- TAR RNA-binding protein of 185 kDa
- TRP-185
|
| Gene Name
| TARBP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| transferase activity |
| nucleic acid binding |
| rna methyltransferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| rna binding |
| Process |
| rna metabolic process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| rna processing |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q42.3 |
| SNPs
| TARBP1 |
| Gene Sequence
|
>4866 bp
ATGGAGTGGGTGCTCGCGGAAGCGCTGCTCTCGCAGAGCCGGGACCCCCGGGCCCTGCTT
GGGGCGCTGTGCCAAGGGGAGGCATCCGCGGAGCGCGTGGAGACGCTGCGCTTCCTTCTG
CAGCGGCTCGAGGACGAGGAGGCGCGCGGCAGCGGGGGCGCAGGCGCGCTCCCGGAGGCG
GCGCGCGAGGTGGCTGCAGGGTACCTCGTGCCACTGCTGCGGAGCCTGCGCGGACGCCCC
GCGGGCGGCCCGGACCCCAGTCTGCAGCCTCGCCACCGCCGGCGCGTGCTGAGGGCGGCG
GGCGCGGCCCTGCGCTCGTGCGTCCGCCTGGCCGGGCGTCCGCAGCTGGCGGCCGCGCTG
GCTGAGGAGGCGCTGCGCGATCTGCTCGCCGGGTGGCGCGCGCCTGGCGCCGAGGCTGCC
GTGGAAGTGCTAGCAGCCGTCGGGCCATGTTTGCGGCCCCGCGAGGACGGGCCGCTACTG
GAGCGCGTGGCGGGGACCGCCGTCGCCCTGGCGCTGGGCGGGGGCGGGGACGGGGATGAG
GCCGGGCCTGCCGAGGACGCGGCGGCGCTGGTGGCCGGGCGACTGCTGCCAGTGCTGGTC
CAATGTGGCGGGGCGGCGCTGCGGGCCGTGTGGGGCGGGCTGGCCGCGCCTGGGGCGTCC
CTGGGGTCCGGCCGCGTAGAGGAGAAGCTGCTGGTCCTGAGCGCCCTGGCCGAGAAGCTG
TTGCCCGAGCCCGGCGGCGACCGCGCCCGCGGCGCGCGCGAGGCGGGCCCGGACGCCCGG
CGCTGCTGGCGCTTCTGGAGGACGGTGCAGGCGGGGCTGGGCCAGGCGGACGCCCTGACG
CGCAAGCGAGCGCGCTACCTGCTGCAGAGGGCGGTGGAGGTGTCGGCGGAGCTGGGGGCC
GACTGCACCTGCGGGCCCCAGGAAGGAAACGGCCCAAGTCTGTTTTGGTGGTCTGAGAGG
AAAAAAGATGAGCTTCTAAAGTTTTGGGAAAATTATATTTTAATTATGGAGACTTTAGAA
GGAAATCAGATACATGTTATAAAGCCAGTTTTACCAAAGCTAAACAATCTGTTTGAATAT
GCGGTGTCAGAGGAAAATGGATGTTGGCTCTTTCACCCATCCTGGCATATGTGTATTTAT
AAAAGAATGTTTGAAAGTGAAAACAAAATCCTGTCCAAAGAAGGTGTTATCCATTTTTTG
GAGCTGTATGAAACAAAGATTCTTCCATTTTCACCAGAATTTTCTGAGTTTATTATTGGA
CCATTAATGGATGCGCTTTCAGAGAGCTCTCTGTATAGCAGGTCCCCAGGCCAGCCAATA
GGAAGCTGTTCTCCATTGGGACTGAAATTACAGAAGTTTTTAGTCACTTATATTTCTCTT
CTTCCAGAAGAAATAAAGAGTAGCTTCCTATTGAAGTTTATTCGGAAGATGACAAGTAGG
CATTGGTGTGCTGTTCCCATTTTGTTTCTATCTAAGGCTTTGGCAAATGTCCCAAGACAT
AAGGCCCTGGGTATAGATGGGCTTCTTGCTCTCAGGGATGTTATTCATTGCACTATGATC
ACACATCAGATTCTCCTGAGAGGGGCAGCCCAATGCTACCTTCTTCAAACAGCTATGAAT
TTGCTAGATGTGGAGAAAGTGTCACTTTCTGATGTCTCAACTTTTCTCATGTCTCTGAGA
CAAGAGGAATCCTTAGGACGAGGAACTTCATTGTGGACAGAGCTGTGTGACTGGCTACGT
GTTAATGAAAGCTATTTTAAGCCATCCCCTACGTGTAGCTCCATTGGACTTCACAAGACA
TCTTTAAATGCTTATGTAAAGAGCATTGTTCAAGAGTATGTTAAGTCATCTGCTTGGGAA
ACAGGAGAAAACTGCTTTATGCCTGATTGGTTTGAAGCCAAGCTTGTTTCTCTGATGGTC
TTGCTGGCTGTGGATGTGGAAGGAATGAAGACTCAGTATAGCGGAAAGCAGAGAACAGAG
AATGTATTGCGGATATTCTTAGACCCTCTTCTGGATGTGCTTATGAAGTTTAGTACCAAT
GCCTACATGCCCTTGCTGAAGACTGACAGATGCCTCCAGCTGCTGTTGAAGCTGTTGAAC
ACATGCAGGTTGAAAGGTTCCAGTGCCCAAGATGATGAGGTGTCTACTGTTCTTCAGAAC
TTTTTCATGTCTACTACAGAGAGCATTTCTGAATTTATTCTCAGAAGACTTACTATGAAT
GAGCTAAATAGTGTTTCAGATCTGGATCGTTGCCATTTATACCTGATGGTGTTAACTGAG
CTTATAAATCTGCATTTGAAGGTTGGGTGGAAAAGGGGTAACCCTATCTGGAGAGTTATT
TCTCTTTTGAAAAATGCATCCATTCAGCATCTTCAAGAGATGGACAGTGGACAGGAGCCA
ACAGTTGGAAGTCAGATTCAGAGAGTAGTGAGCATGGCTGCCTTGGCCATGGTGTGTGAG
GCCATAGACCAGAAGCCTGAGCTGCAGCTGGACTCTCTCCATGCTGGGCCCCTGGAAAGC
TTCCTTTCCTCTCTTCAGCTCAATCAGACGCTGCAGAAGCCCCACGCAGAGGAGCAGAGC
AGTTATGCTCACCCCTTGGAGTGCAGCAGTGTTTTGGAAGAATCGTCATCTTCCCAAGGA
TGGGGAAAAATAGTTGCACAATATATTCATGATCAATGGGTGTGCCTCTCTTTCCTGTTG
AAAAAATATCACACCCTTATACCAACCACAGGGAGTGAAATTCTGGAACCGTTTCTACCT
GCCGTTCAGATGCCAATAAGGACTTTGCAGTCTGCACTAGAAGCCCTCACAGTTCTTTCT
TCTGATCAAGTTTTACCAGTGTTCCATTGCTTGAAAGTGTTGGTTCCCAAGCTTCTGACT
TCCTCTGAATCACTCTGCATAGAGTCTTTTGACATGGCGTGGAAAATTATATCTTCTTTA
AGCAACACTCAGCTGATATTCTGGGCTAATTTAAAAGCTTTTGTTCAGTTTGTTTTTGAT
AACAAAGTTCTTACCATTGCTGCCAAAATCAAGGGCCAGGCATATTTCAAAATAAAAGAG
ATTATGTACAAGATAATTGAAATGTCTGCTATAAAGACTGGAGTCTTCAATACACTGATA
AGTTACTGCTGTCAGTCTTGGATAGTGTCTGCTTCAAATGTGTCCCAAGGATCTTTATCA
AGTGCTAAAAATTATAGCGAACTTATCCTTGAGGCTTGTATATTTGGAACTGTGTTTAGG
CGTGATCAAAGACTTGTTCAGGATGTACAGACCTTCATAGAAAACCTTGGACATGACTGT
GCGGCAAATATTGTTATGGAAAATACTAAGAGAGAAGACCATTATGTGAGAATTTGTGCT
GTCAAATTCCTGTGTTTATTAGATGGCTCCAATATGTCCCACAAGTTGTTTATTGAGGAT
CTTGCAATCAAGCTATTAGATAAAGATGAATTAGTGTCCAAGTCCAAAAAACGCTACTAT
GTGAATTCTCTACAGCACAGAGTGAAAAACCGAGTGTGGCAGACTCTGCTGGTACTTTTC
CCTAGACTTGACCAGAATTTCTTGAATGGAATTATTGACAGGATTTTCCAGGCTGGTTTC
ACCAACAATCAAGCATCCATAAAATATTTTATAGAATGGATTATTATATTGATTCTTCAT
AAATTCCCTCAATTTCTTCCAAAGTTCTGGGATTGTTTTTCTTATGGTGAAGAAAATCTT
AAAACAAGCATTTGTACGTTTTTAGCAGTTTTATCACATTTAGACATTATTACTCAAAAT
ATTCCAGAAAAGAAACTAATTCTGAAGCAAGCCCTTATAGTTGTGCTGCAGTGGTGTTTC
AATCACAATTTTAGTGTTCGACTGTATGCTTTAGTTGCTCTTAAGAAACTCTGGACTGTG
TGTAAAGTGTTAAGTGTTGAAGAATTTGATGCCCTGACTCCTGTGATTGAATCCAGCCTC
CATCAAGTGGAAAGCATGCACGGAGCAGGGAATGCCAAGAAGAATTGGCAACGCATTCAG
GAGCATTTCTTTTTTGCAACATTTCACCCACTCAAGGATTATTGTCTAGAGACCATATTT
TACATCCTTCCACGCCTTTCAGGCCTTATTGAAGATGAATGGATCACCATTGATAAATTT
ACCAGATTCACTGATGTTCCTTTAGCTGCGGGATTTCAGTGGTACCTTTCTCAAACTCAA
CTTAGTAAACTAAAACCAGGTGACTGGTCTCAGCAAGACATAGGTACTAATTTGGTCGAA
GCAGATAACCAAGCGGAGTGGACCGACGTTCAGAAGAAGATTATCCCGTGGAACAGTCGT
GTTTCCGACTTAGACCTGGAGCTCCTGTTTCAGGATCGTGCTGCCAGACTTGGAAAGTCA
ATTAGTAGACTCATCGTTGTGGCCTCGCTCATCGACAAACCGACCAATTTAGGAGGACTG
TGCAGGACCTGTGAGGTATTTGGGGCTTCAGTGCTCGTTGTTGGCAGCCTTCAGTGTATC
AGCGACAAACAGTTTCAGCACCTCAGTGTCTCTGCAGAACAGTGGCTTCCTCTAGTGGAG
GTAAAACCACCTCAGCTAATTGATTATCTGCAGCAGAAGAAAACAGAAGGTTATACCATC
ATTGGAGTGGAACAAACTGCCAAAAGTTTAGACCTAACCCAATATTGCTTTCCTGAGAAA
TCTCTGCTCTTGTTGGGAAATGAACGTGAGGGAATTCCAGCAAATCTGATCCAACAGTTG
GACGTTTGTGTGGAAATTCCTCAACAGGGCATTATCCGCTCCCTGAATGTCCATGTGAGT
GGAGCCCTGCTGATCTGGGAGTACACCAGGCAGCAGCTGCTCTCGCACGGAGATACCAAG
CCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 1621 |
| Molecular Weight
| 181672.8 |
| Theoretical pI
| 7.05 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Probable methyltransferase TARBP1
MEWVLAEALLSQSRDPRALLGALCQGEASAERVETLRFLLQRLEDEEARGSGGAGALPEA
AREVAAGYLVPLLRSLRGRPAGGPDPSLQPRHRRRVLRAAGAALRSCVRLAGRPQLAAAL
AEEALRDLLAGWRAPGAEAAVEVLAAVGPCLRPREDGPLLERVAGTAVALALGGGGDGDE
AGPAEDAAALVAGRLLPVLVQCGGAALRAVWGGLAAPGASLGSGRVEEKLLVLSALAEKL
LPEPGGDRARGAREAGPDARRCWRFWRTVQAGLGQADALTRKRARYLLQRAVEVSAELGA
DCTCGPQEGNGPSLFWWSERKKDELLKFWENYILIMETLEGNQIHVIKPVLPKLNNLFEY
AVSEENGCWLFHPSWHMCIYKRMFESENKILSKEGVIHFLELYETKILPFSPEFSEFIIG
PLMDALSESSLYSRSPGQPIGSCSPLGLKLQKFLVTYISLLPEEIKSSFLLKFIRKMTSR
HWCAVPILFLSKALANVPRHKALGIDGLLALRDVIHCTMITHQILLRGAAQCYLLQTAMN
LLDVEKVSLSDVSTFLMSLRQEESLGRGTSLWTELCDWLRVNESYFKPSPTCSSIGLHKT
SLNAYVKSIVQEYVKSSAWETGENCFMPDWFEAKLVSLMVLLAVDVEGMKTQYSGKQRTE
NVLRIFLDPLLDVLMKFSTNAYMPLLKTDRCLQLLLKLLNTCRLKGSSAQDDEVSTVLQN
FFMSTTESISEFILRRLTMNELNSVSDLDRCHLYLMVLTELINLHLKVGWKRGNPIWRVI
SLLKNASIQHLQEMDSGQEPTVGSQIQRVVSMAALAMVCEAIDQKPELQLDSLHAGPLES
FLSSLQLNQTLQKPHAEEQSSYAHPLECSSVLEESSSSQGWGKIVAQYIHDQWVCLSFLL
KKYHTLIPTTGSEILEPFLPAVQMPIRTLQSALEALTVLSSDQVLPVFHCLKVLVPKLLT
SSESLCIESFDMAWKIISSLSNTQLIFWANLKAFVQFVFDNKVLTIAAKIKGQAYFKIKE
IMYKIIEMSAIKTGVFNTLISYCCQSWIVSASNVSQGSLSSAKNYSELILEACIFGTVFR
RDQRLVQDVQTFIENLGHDCAANIVMENTKREDHYVRICAVKFLCLLDGSNMSHKLFIED
LAIKLLDKDELVSKSKKRYYVNSLQHRVKNRVWQTLLVLFPRLDQNFLNGIIDRIFQAGF
TNNQASIKYFIEWIIILILHKFPQFLPKFWDCFSYGEENLKTSICTFLAVLSHLDIITQN
IPEKKLILKQALIVVLQWCFNHNFSVRLYALVALKKLWTVCKVLSVEEFDALTPVIESSL
HQVESMHGAGNAKKNWQRIQEHFFFATFHPLKDYCLETIFYILPRLSGLIEDEWITIDKF
TRFTDVPLAAGFQWYLSQTQLSKLKPGDWSQQDIGTNLVEADNQAEWTDVQKKIIPWNSR
VSDLDLELLFQDRAARLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCI
SDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGVEQTAKSLDLTQYCFPEK
SLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQLLSHGDTK
P
|
| External Links |
|---|
| GenBank ID Protein
| 56204383 |
| UniProtKB/Swiss-Prot ID
| Q13395 |
| UniProtKB/Swiss-Prot Entry Name
| TARB1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL136124 |
| GeneCard ID
| TARBP1 |
| GenAtlas ID
| TARBP1 |
| HGNC ID
| HGNC:11568 |
| References |
|---|
| General References
| Not Available |