| Identification |
|---|
| HMDB Protein ID
| CDBP04231 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histone-lysine N-methyltransferase SUV420H2 |
| Description
| Not Available |
| Synonyms
|
- Lysine N-methyltransferase 5C
- Su(var)4-20 homolog 2
- Suppressor of variegation 4-20 homolog 2
- Suv4-20h2
|
| Gene Name
| SUV420H2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).
|
| GO Classification
|
| Biological Process |
| histone H4-K20 trimethylation |
| regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| Cellular Component |
| condensed nuclear chromosome, centromeric region |
| Molecular Function |
| histone methyltransferase activity (H4-K20 specific) |
|
| Cellular Location
|
- Nucleus
- Chromosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13.42 |
| SNPs
| SUV420H2 |
| Gene Sequence
|
>1389 bp
ATGGGGCCCGACAGAGTGACAGCACGAGAACTGTGCGAGAACGACGACCTGGCCACCAGC
CTCGTCCTGGACCCCTACCTCGGTTTCCGCACCCATAAGATGAACGTCAGCCCTGTGCCC
CCCCTGCGGCGACAGCAGCACCTGCGCTCAGCGCTGGAAACTTTCCTGAGGCAGCGGGAC
CTGGAGGCTGCGTACCGGGCCCTGACGCTGGGAGGCTGGACGGCCCGCTACTTCCAGAGC
CGGGGCCCGCGGCAGGAGGCTGCCCTCAAGACCCACGTCTATCGCTACCTCCGTGCCTTC
CTGCCGGAAAGTGGCTTTACCATCCTGCCCTGCACGCGCTACTCCATGGAGACCAACGGG
GCCAAGATCGTGTCCACTCGTGCTTGGAAAAAGAATGAGAAGCTGGAGCTGCTGGTGGGC
TGCATTGCAGAGCTGCGGGAGGCAGATGAGGGGCTGCTGAGGGCCGGTGAGAATGACTTC
AGCATCATGTACTCAACCCGCAAGCGGAGTGCTCAGCTGTGGCTGGGCCCAGCCGCCTTC
ATCAACCATGACTGCAAACCCAACTGCAAGTTTGTGCCTGCAGATGGGAACGCAGCCTGC
GTGAAGGTGCTCCGGGACATTGAGCCTGGGGACGAGGTGACATGCTTCTACGGCGAGGGC
TTCTTCGGCGAGAAGAATGAGCACTGTGAATGCCACACCTGTGAGAGGAAAGGTGAAGGA
GCTTTCCGAACCAGGCCTAGGGAGCCCGCGTTGCCACCACGGCCCCTGGACAAGTACCAG
CTGCGTGAGACCAAGCGGCGGCTGCAGCAAGGCCTGGACAGTGGCAGCCGACAGGGCCTG
CTGGGCCCTCGGGCCTGCGTGCACCCATCCCCGCTGCGCCGGGACCCATTCTGCGCCGCC
TGCCAGCCCCTGCGCCTGCCAGCCTGCAGCGCCCGCCCAGACACCTCACCCCTCTGGCTC
CAGTGGCTGCCTCAGCCCCAGCCCCGAGTGCGGCCCCGGAAGCGCCGACGCCCCCGGCCC
CGGAGGGCCCCAGTGCTCTCCACCCACCACGCTGCCCGCGTCTCCCTGCACCGATGGGGA
GGCTGTGGCCCCCACTGCCGCCTGCGAGGAGAGGCCCTGGTGGCCCTGGGCCAGCCCCCC
CACGCCCGCTGGGCCCCTCAGCAGGACTGGCACTGGGCCCGGCGCTATGGGCTGCCTTAC
GTGGTGCGTGTGGACCTTCGTCGCCTGGCCCCAGCCCCACCAGCTACCCCAGCCCCTGCT
GGGACCCCAGGCCCCATCCTGATCCCGAAGCAGGCCCTCGCCTTCGCCCCCTTCTCCCCA
CCCAAGCGCCTACGGCTGGTGGTCAGCCACGGCTCCATCGACCTGGATGTCGGCGGTGAA
GAGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 462 |
| Molecular Weight
| 52112.445 |
| Theoretical pI
| 9.834 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone-lysine N-methyltransferase SUV420H2
MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPPLRRQQHLRSALETFLRQRD
LEAAYRALTLGGWTARYFQSRGPRQEAALKTHVYRYLRAFLPESGFTILPCTRYSMETNG
AKIVSTRAWKKNEKLELLVGCIAELREADEGLLRAGENDFSIMYSTRKRSAQLWLGPAAF
INHDCKPNCKFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECHTCERKGEG
AFRTRPREPALPPRPLDKYQLRETKRRLQQGLDSGSRQGLLGPRACVHPSPLRRDPFCAA
CQPLRLPACSARPDTSPLWLQWLPQPQPRVRPRKRRRPRPRRAPVLSTHHAARVSLHRWG
GCGPHCRLRGEALVALGQPPHARWAPQQDWHWARRYGLPYVVRVDLRRLAPAPPATPAPA
GTPGPILIPKQALAFAPFSPPKRLRLVVSHGSIDLDVGGEEL
|
| External Links |
|---|
| GenBank ID Protein
| 31543169 |
| UniProtKB/Swiss-Prot ID
| Q86Y97 |
| UniProtKB/Swiss-Prot Entry Name
| SV422_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_032701.3 |
| GeneCard ID
| SUV420H2 |
| GenAtlas ID
| SUV420H2 |
| HGNC ID
| HGNC:28405 |
| References |
|---|
| General References
| Not Available |