| Identification |
|---|
| HMDB Protein ID
| CDBP04208 |
| Secondary Accession Numbers
| Not Available |
| Name
| mRNA cap guanine-N7 methyltransferase |
| Description
| Not Available |
| Synonyms
|
- RG7MT1
- hCMT1
- hMet
- hcm1p
- mRNA (guanine-N(7)-)-methyltransferase
- mRNA cap methyltransferase
|
| Gene Name
| RNMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in mRNA capping |
| Specific Function
| mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.
|
| GO Classification
|
| Biological Process |
| transcription from RNA polymerase II promoter |
| viral reproduction |
| Cellular Component |
| nucleolus |
| nucleoplasm |
| mRNA cap binding complex |
| Molecular Function |
| RNA binding |
| mRNA (guanine-N7-)-methyltransferase activity |
| Process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| rna processing |
| mrna processing |
| mrna capping |
| rna metabolic process |
| metabolic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | mRNA surveillance pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18p11.21 |
| SNPs
| RNMT |
| Gene Sequence
|
>1431 bp
ATGGCAAATTCTGCAAAAGCAGAAGAATATGAAAAGATGTCTCTTGAACAGGCAAAAGCG
TCAGTGAATTCTGAAACAGAGTCTTCATTCAATATTAATGAAAACACAACAGCTTCTGGG
ACTGGGCTTTCTGAAAAGACTTCTGTCTGTAGGCAAGTAGACATAGCAAGAAAGAGAAAA
GAGTTTGAAGATGATCTTGTAAAGGAAAGTTCTAGTTGTGGGAAAGACACTCCATCCAAG
AAGAGAAAACTTGATCCTGAAATTGTCCCAGAGGAAAAAGATTGTGGTGATGCTGAAGGC
AATTCAAAGAAAAGAAAAAGAGAAACTGAGGATGTTCCAAAAGATAAATCTTCTACTGGA
GATGGCACTCAAAATAAGAGAAAAATAGCACTTGAGGATGTTCCTGAAAAGCAGAAAAAT
CTGGAAGAAGGACACAGCTCAACAGTGGCTGCCCATTACAATGAACTTCAGGAAGTTGGT
TTGGAGAAGCGTAGTCAAAGTCGTATTTTTTACCTAAGAAACTTTAATAATTGGATGAAA
AGTGTTCTCATTGGAGAATTTTTGGAAAAGGTACGACAGAAGAAAAAACGTGATATCACT
GTTTTGGACCTGGGATGTGGTAAAGGTGGAGATTTGCTGAAATGGAAAAAAGGAAGAATT
AACAAGCTAGTTTGTACTGATATTGCCGATGTTTCTGTCAAACAGTGTCAGCAGCGGTAT
GAGGACATGAAAAATCGTCGTGATAGTGAATATATTTTCAGTGCAGAATTTATAACTGCT
GACAGCTCAAAGGAACTTCTGATTGACAAATTTCGTGACCCACAAATGTGTTTTGACATC
TGCAGTTGTCAGTTTGTCTGTCATTACTCATTTGAGTCTTATGAGCAGGCTGACATGATG
CTGAGAAATGCGTGTGAGAGACTTAGCCCTGGGGGCTATTTTATTGGTACTACTCCCAAT
AGCTTTGAATTGATAAGACGCCTTGAAGCTTCAGAAACAGAATCATTTGGAAATGAAATA
TATACTGTGAAATTTCAGAAGAAAGGAGATTATCCTTTATTTGGCTGCAAATATGACTTC
AACTTGGAAGGTGTTGTGGATGTTCCTGAATTCTTGGTCTATTTTCCATTGCTAAATGAA
ATGGCAAAGAAGTACAATATGAAACTAGTCTACAAAAAAACATTTCTGGAATTCTACGAA
GAAAAGATTAAGAACAATGAAAATAAAATGCTCTTAAAACGAATGCAGGCCTTGGAGCCA
TATCCTGCAAATGAGAGTTCTAAACTTGTCTCTGAGAAGGTGGATGACTATGAACATGCA
GCAAAGTACATGAAGAACAGTCAAGTAAGGTTACCTTTGGGAACCTTAAGTAAATCAGAA
TGGGAAGCTACAAGTATTTACTTGGTGTTTGCCTTTGAGAAACAGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 476 |
| Molecular Weight
| 54843.655 |
| Theoretical pI
| 6.614 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>mRNA cap guanine-N7 methyltransferase
MANSAKAEEYEKMSLEQAKASVNSETESSFNINENTTASGTGLSEKTSVCRQVDIARKRK
EFEDDLVKESSSCGKDTPSKKRKLDPEIVPEEKDCGDAEGNSKKRKRETEDVPKDKSSTG
DGTQNKRKIALEDVPEKQKNLEEGHSSTVAAHYNELQEVGLEKRSQSRIFYLRNFNNWMK
SVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRY
EDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMM
LRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDF
NLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEP
YPANESSKLVSEKVDDYEHAAKYMKNSQVRLPLGTLSKSEWEATSIYLVFAFEKQQ
|
| External Links |
|---|
| GenBank ID Protein
| 2662077 |
| UniProtKB/Swiss-Prot ID
| O43148 |
| UniProtKB/Swiss-Prot Entry Name
| MCES_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB007858 |
| GeneCard ID
| RNMT |
| GenAtlas ID
| RNMT |
| HGNC ID
| HGNC:10075 |
| References |
|---|
| General References
| Not Available |