| Identification |
|---|
| HMDB Protein ID
| CDBP04182 |
| Secondary Accession Numbers
| Not Available |
| Name
| Threonine synthase-like 2 |
| Description
| Not Available |
| Synonyms
|
- TSH2
|
| Gene Name
| THNSL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| cofactor binding |
| pyridoxal phosphate binding |
| Process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p11.2 |
| SNPs
| THNSL2 |
| Gene Sequence
|
>1455 bp
ATGTGGTATGTCAGCACCAGGGGCGTAGCCCCACGGGTCAACTTTGAGGGGGCCCTCTTC
TCTGGCTATGCACCTGACGGGGGCCTCTTTATGCCTGAAGAGCTCCCACAGTTGGACAGA
GGGACCCTGTGCCAGTGGAGCACACTCTCCTATCCTGGCCTGGTGAAGGAGCTGTGTGCC
CTCTTCATTGGCTCTGAGCTCCTTCCAAAAGATGAATTAAATGATCTGATCGACCGAGCC
TTCAGCAGATTCCGTCACAGAGAAGTGGTCCATCTGTCCAGGTTGAGGAATGGGCTGAAC
GTGTTGGAGCTGTGGCATGGCGTCACATATGCATTTAAGGACCTGTCCCTGTCCTGCACA
ACACAGTTCCTGCAGTACTTCCTGGAGAAGAGGGAGAAGCACGTCACTGTGGTTGTAGGA
ACATCTGGGGACACAGGAAGTGCTGCCATTGAGAGTGTTCAAGGGGCAAAGAACATGGAC
ATTATCGTTCTGCTGCCCAAAGGTCACTGCACAAAGATTCAGGAGCTCCAGATGACAACG
GTGCTGAAGCAGAACGTACATGTGTTTGGAGTGGAGGGAAACAGCGATGAGCTCGATGAG
CCGATCAAGACTGTGTTTGCCGATGTGGCTTTTGTCAAGAAGCACAATCTGATGAGCCTG
AATTCGATCAACTGGTCCCGGGTCCTGGTGCAGATGGCCCATCACTTCTTTGCTTACTTC
CAGTGTACGCCATCCTTGGACACACATCCCCTACCCCTGGTGGAGGTGGTTGTGCCAACA
GGGGCTGCCGGTAACCTTGCAGCTGGGTACATTGCTCAAAAGATAGGCCTGCCCATCCGT
CTGGTCGTGGCAGTGAACCGCAATGACATCATCCACAGGACTGTCCAGCAGGGAGACTTC
TCTCTCTCTGAGGCTGTTAAATCAACCTTGGCATCAGCTATGGACATTCAGGTGCCCTAC
AACATGGAGAGGGTGTTCTGGCTGCTCTCTGGCTCTGACAGCCAGGTGACAAGAGCCCTC
ATGGAGCAGTTTGAAAGGACCCAAAGTGTGAATCTGCCCAAGGAACTGCACAGCAAGCTT
TCAGAGGCAGTGACATCCGTGTCAGTGTCGGATGAAGCCATCACCCAGACCATGGGCCGC
TGCTGGGATGAGAACCAGTACTTGCTGTGCCCCCACTCAGCGGTGGCCGTGAACTACCAT
TACCAGCAGATAGACAGGCAGCAGCCCAGCACTCCCCGGTGCTGCCTCGCCCCTGCCTCT
GCAGCCAAGTTCCCGGAAGCTGTCCTGGCTGCTGGCCTGACCCCTGAGACTCCCGCGGAG
ATCGTAGCCCTGGAGCACAAGGAGACACGCTGCACCCTGATGCGGAGAGGTGACAACTGG
ATGCTGATGCTTCGGGACACCATTGAGGACCTTAGCCGACAGTGGAGGAGTCATGCCCTC
AACACCTCCCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 484 |
| Molecular Weight
| 54187.6 |
| Theoretical pI
| 6.41 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Threonine synthase-like 2
MWYVSTRGVAPRVNFEGALFSGYAPDGGLFMPEELPQLDRETLCQWSTLSYPGLVKELCA
LFIGSELLPKDELNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLSCT
TQFLQYFLEKREKHVTVVVGTSGDTGSAAIESVQGAKNMDIIVLLPKGHCTKIQELQMTT
VLKQNVHVFGVEGNSDELDEPIKTVFADVAFVKKHNLMSLNSINWSRVLVQMAHHFFAYF
QCTPSLDTHPLPLVEVVVPTGAAGNLAAGYIAQKIGLPIRLVVAVNRNDIIHRTVQQGDF
SLSEAVKSTLASAMDIQVPYNMERVFWLLSGSDSQVTRALMEQFERTQSVNLPKELHSKL
SEAVTSVSVSDEAITQTMGRCWDENQYLLCPHSAVAVNYHYQQIDRQQPSTPRCCLAPAS
AAKFPEAVLAAGLTPETPAEIVALEHKETRCTLMRRGDNWMLMLRDTIEDLSRQWRSHAL
NTSQ
|
| External Links |
|---|
| GenBank ID Protein
| 149193323 |
| UniProtKB/Swiss-Prot ID
| Q86YJ6 |
| UniProtKB/Swiss-Prot Entry Name
| THNS2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018271.3 |
| GeneCard ID
| THNSL2 |
| GenAtlas ID
| THNSL2 |
| HGNC ID
| HGNC:25602 |
| References |
|---|
| General References
| Not Available |