Cannabis Compound Database: Showing Protein Receptor-type tyrosine-protein phosphatase R (CDBP04158)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04158

Secondary Accession Numbers

Not Available

Name

Receptor-type tyrosine-protein phosphatase R

Description

Not Available

Synonyms

Ch-1PTPase
NC-PTPCOM1
Protein-tyrosine phosphatase PCPTP1
R-PTP-R

Gene Name

PTPRR

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

GO Classification

Biological Process
in utero embryonic development
neuron differentiation
Cellular Component
plasma membrane
perinuclear region of cytoplasm
nucleus
integral to membrane
cell surface
cytoplasm
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
protein kinase binding
transmembrane receptor protein tyrosine phosphatase activity
Process
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation

Cellular Location

perinuclear region
Isoform Gamma:Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
MAPK signaling pathway	Not Available

Gene Properties

Chromosome Location

Locus

12q15

SNPs

PTPRR

Gene Sequence

>1974 bp
ATGCGGAGAGCAGTCTGCTTCCCTGCGCTGTGCCTGCTCCTTAATCTTCACGCTGCAGGG
TGCTTTTCAGGAAACAATGATCATTTTTTGGCAATTAATCAGAAGAAGAGTGGGAAGCCG
GTATTCATTTATAAGCATTCACAAGACATTGAGAAGAGCCTGGATATAGCCCCACAAAAA
ATCTACAGACATAGCTACCATTCCTCTTCCGAAGCTCAAGTAAGCAAACGCCACCAGATT
GTCAATTCAGCATTTCCTAGACCCGCATATGACCCGTCTCTCAATCTGCTGGCCATGGAT
GGTCAAGATCTTGAAGTGGAAAATCTCCCAATCCCAGCAGCAAATGTAATTGTGGTGACA
CTGCAAATGGATGTAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTG
GCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATCGCCTCATTGGAAAGAAG
AACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTG
CCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTATCCCAG
TTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAGGGCAGCATGAAGCGGAC
AAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATT
ATAGTAACGTGTTTGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGA
CAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCACATTACAGCCAGCACTG
TCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAAT
GTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAGATCAGAGCTACCACCGCTACCTCT
GTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAGAGAGAAGAGGGTCCAAC
GTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCA
ACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGG
TCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAAGTGAATTCATGGAAATA
CCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGC
TATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACC
GATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAA
GCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTT
TGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAATGAGAAA
TGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATC
AGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCAC
ACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCAGACAGT
GCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGC
CGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCT
ACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTC
TGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTG
CACCATGCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGA

Protein Properties

Number of Residues

657

Molecular Weight

51045.62

Theoretical pI

8.009

Pfam Domain Function

Y_phosphatase (PF00102 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Receptor-type tyrosine-protein phosphatase R
MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQK
IYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPAANVIVVT
LQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDAL
PSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVI
IVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLN
VVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIP
TPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNR
YKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMV
WQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSH
TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIA
TSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ

External Links

GenBank ID Protein

4506325

UniProtKB/Swiss-Prot ID

Q15256

UniProtKB/Swiss-Prot Entry Name

PTPRR_HUMAN

PDB IDs