| Identification |
|---|
| HMDB Protein ID
| CDBP04157 |
| Secondary Accession Numbers
| Not Available |
| Name
| Receptor-type tyrosine-protein phosphatase O |
| Description
| Not Available |
| Synonyms
|
- Glomerular epithelial protein 1
- PTP-U2
- PTPase U2
- Protein tyrosine phosphatase U2
- R-PTP-O
|
| Gene Name
| PTPRO |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
|
| GO Classification
|
| Biological Process |
| axon guidance |
| glomerular visceral epithelial cell differentiation |
| lamellipodium assembly |
| monocyte chemotaxis |
| negative regulation of canonical Wnt receptor signaling pathway |
| negative regulation of cell-substrate adhesion |
| negative regulation of neuron projection development |
| negative regulation of glomerular filtration |
| negative regulation of retinal ganglion cell axon guidance |
| slit diaphragm assembly |
| Cellular Component |
| dendritic spine |
| lamellipodium |
| lateral plasma membrane |
| apical plasma membrane |
| axon |
| integral to plasma membrane |
| growth cone |
| Function |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| transmembrane receptor protein tyrosine phosphatase activity |
| protein homodimerization activity |
| Wnt-protein binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12p13-p12 |
| SNPs
| PTPRO |
| Gene Sequence
|
>3651 bp
ATGGGGCACCTGCCCACGGGGATACACGGCGCCCGCCGCCTCCTGCCTCTGCTCTGGCTC
TTTGTGCTGTTCAAGAATGCTACAGCTTTCCATGTAACTGTCCAAGATGATAATAACATC
GTTGTCTCATTAGAAGCTTCAGACGTCATCAGTCCAGCATCTGTGTATGTTGTGAAGATA
ACTGGTGAATCCAAAAATTATTTCTTCGAATTTGAGGAATTCAACAGCACTTTGCCTCCT
CCTGTTATTTTCAAGGCCAGTTATCATGGCCTTTATTATATAATCACTCTGGTAGTGGTA
AATGGAAATGTGGTGACCAAGCCATCCAGATCAATCACTGTGTTAACAAAACCTCTACCT
GTAACCAGTGTTTCCATATATGACTATAAACCTTCTCCTGAAACAGGAGTCCTGTTTGAA
ATACATTATCCAGAAAAATATAACGTTTTCACAAGAGTGAACATTAGCTACTGGGGAGGT
AAAGACTTCCGGACAATGCTATATAAAGATTTCTTTAAGGGAAAAACAGTATTTAATCAC
TGGCTGCCAGGAATGTGTTATAGTAATATCACCTTTCAGCTGGTATGTGAGGCAACTTTT
AATAAAAGTACCGTTGTTGAGTACAGTGGTGTCAGTCACGAACCCAAACAGCACAGAACT
GCCCCTTATCCACCTCAAAACATTTCCGTTCGTATCGTAAACTTGAACAAAAACAACTGG
GAAGAACAGAGTGGCAATTTCCCAGAAGAATCCTTCATGAGATCACAAGATACAATAGGA
AAAGAAAAACTCTTCCATTTTACAGAAGAAACCCCTGAAATTCCCTCGGGCAACATTTCT
TCCGGTTGGCCTGATTTTAATAGCAGTGACTATGAAACTACGTCTCAGCCATATTGGTGG
GACAGTGCATCTGCAGCTCCTGAAAGTGAAGATGAATTTTTCAGCGTACTTCCCATGGAA
TACGAAAATAACAGTACACTCAGTGAGACAGAGAAGTCAACATCAGGCTCTTTCTCCTTT
TTCCCTGTGCAAATGATATTGACCTGGTTACCACCCAAACCACCCACTGCTTTTGATGGG
TTCCATATCCATATTGAACGAGAAGAGAACTTTACTGAATATTTGATGGTGGATGAAGAA
GCACATGAATTTGTTGCAGAACTGAAGGAACCTGGGAAATATAAGTTATCTGTGACAACC
TTTAGTTCCTCAGGATCTTGTGAAACTCGAAAAAGTCAGTCAGCAAAATCACTCAGCTTT
TATATCAGTCCTTCAGGAGAGTGGATTGAAGAACTGACCGAGAAGCCGCAGCACGTGAGT
TTCCACGTTTTAAGCTCAACCACTGCCTTGATGTCCTGGACATCTTCCCAAGAGAACTAC
AACAGCACCATTGTGTCTGTGGTGTCGCTGACCTGCCAGAAACAAAAGGAGAGCCAGAGG
CTTGAAAAGCAGTACTGCACTCAGGTGAACTCAAGCAAACCTATTATTGAAAATCTGGTT
CCTGGTGCCCAGTACCAGGTTGTAATATACCTAAGGAAAGGCCCTTTGATTGGACCACCT
TCAGATCCTGTGACATTTGCTATTGTTCCCACAGGAATAAAGGATTTAATGCTCTATCCT
TTGGGTCCTACGGCCGTGGTTCTGAGCTGGACCAGACCTTATTTAGGCGTGTTCAGAAAA
TACGTGGTTGAAATGTTTTATTTCAACCCTGCTACAATGACATCAGAGTGGACCACCTAC
TATGAAATAGCAGCAACTGTTTCCTTAACTGCATCCGTGAGAATAGCTAATCTGCTGCCA
GCATGGTACTACAACTTCCGGGTTACCATGGTGACGTGGGGAGATCCAGAACTGAGCTGC
TGTGACAGCTCTACCATCAGCTTCATAACAGCCCCAGTGGCTCCGGAAATCACTTCTGTG
GAATATTTCAACAGTCTGTTATATATCAGTTGGACATATGGGGATGATACAACGGACTTG
TCCCATTCTAGAATGCTTCACTGGATGGTGGTTACAGAAGGAAAAAAGAAAATTAAAAAG
AGTGTAACACGCAATGTCATGACTGCAATTCTCAGCTTGCCTCCAGGCGACACCTATAAC
CTCTCAGTAACTACTTGTACTGAAAGAGGAAGTAATACCTCCATGCTCCGCCTTGTCAAG
CTAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACT
TTGCTGTGGGTGGAAGAGGGAGTAGCTGATTTCTTTAAAGTTTTCTTTCAACACGTTGGC
TCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTCCCCATGTGGTGACCATC
TCCAGCCTTCTTCCTGCCACTGCCTACAGTTGTAGTGTCACCAGCTTTAGCCATGACAGC
CCCAGTGTCCCTACGTTCATAGCCGTCTCAACAATGGTTACAGAGATGAATCCCAATGTG
GTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACC
CTCATTATTCTTAGGAAAAAGCATCTGCAGATGGCTAGGGAGTGTGGAGCTGGTACATTT
GCCAATTGTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACTGCCGTAGGAGTATA
TTTGCTTTCTTAACCCTGCTACCATCATGTCTTTGGACTGATTATCCTTTGGCATTTTAT
ATTAATCCTTGGAGTAAAAATGGTTTAAAGAAGAGGAAACTGACAAACCCGGTTCAACTG
GATGACTTTGATGCCTATATTAAGGATATGGCCAAAGACTCTGACTATAAATTTTCTCTT
CAGTTTGAGGAGTTGAAATTGATTGGACTGGATATCCCACACTTTGCTGCAGATCTTCCA
CTGAATCGATGTAAAAACCGTTACACAAACATCCTACCATATGACTTCAGCCGTGTGAGA
TTAGTCTCCATGAATGAAGAGGAAGGTGCAGACTACATCAATGCCAACTATATTCCTGGA
TACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGAC
TTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAAT
GAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTAT
GGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACAC
TTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGG
CCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATG
GTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTG
GGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAG
TTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAG
ACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAG
CAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1216 |
| Molecular Weight
| 134939.865 |
| Theoretical pI
| 5.955 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Receptor-type tyrosine-protein phosphatase O
MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI
TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP
VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH
WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW
EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW
DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG
FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF
YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR
LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP
LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP
AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL
SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK
LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI
SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT
LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFY
INPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLP
LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRND
FWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRH
FRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGV
GRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
QQFCISDVIYENVSKS
|
| External Links |
|---|
| GenBank ID Protein
| 963059 |
| UniProtKB/Swiss-Prot ID
| Q16827 |
| UniProtKB/Swiss-Prot Entry Name
| PTPRO_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Z48541 |
| GeneCard ID
| PTPRO |
| GenAtlas ID
| PTPRO |
| HGNC ID
| HGNC:9678 |
| References |
|---|
| General References
| Not Available |