| Identification |
|---|
| HMDB Protein ID
| CDBP04156 |
| Secondary Accession Numbers
| Not Available |
| Name
| Receptor-type tyrosine-protein phosphatase mu |
| Description
| Not Available |
| Synonyms
|
- Protein-tyrosine phosphatase mu
- R-PTP-mu
|
| Gene Name
| PTPRM |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
|
| GO Classification
|
| Biological Process |
| positive regulation of vasodilation |
| response to drug |
| homophilic cell adhesion |
| negative regulation of endothelial cell migration |
| negative regulation of endothelial cell proliferation |
| retina layer formation |
| retinal ganglion cell axon guidance |
| negative regulation of angiogenesis |
| Cellular Component |
| perinuclear region of cytoplasm |
| lamellipodium |
| cell-cell adherens junction |
| integral to plasma membrane |
| Component |
| membrane |
| cell part |
| Function |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| phosphoprotein phosphatase activity |
| Molecular Function |
| transmembrane receptor protein tyrosine phosphatase activity |
| cadherin binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Cell adhesion molecules (CAMs) | Not Available |  | | Adherens junction | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18p11.2 |
| SNPs
| PTPRM |
| Gene Sequence
|
>4359 bp
ATGAGGACACTTGGGACTTGCCTGGCGACTTTGGCCGGACTTTTGCTAACTGCGGCGGGC
GAGACGTTCTCAGGTGGCTGCCTCTTTGATGAGCCGTATAGCACATGTGGATATAGTCAA
TCTGAAGGTGATGACTTCAATTGGGAGCAAGTGAACACCTTGACTAAACCGACTTCTGAT
CCATGGATGCCATCAGGTTCTCTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGCAG
AGAGCCCACCTGCTCTTACCCCAACTTAAGGAAAATGACACCCACTGCATCGATTTTCAC
TATTTTGTGTCCAGCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTC
AATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAGACCCAACACGTACATGG
AACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAA
GTGATAACTTCTGGACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACAT
CCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCCAG
TTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTA
CAGGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGC
TTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCTGC
ATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAA
CCACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATA
CAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGTAC
TGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATT
GGACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAG
GGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCATG
CGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCACTATCCGCTGG
GAGCCATTTGGATATAATGTAACTCGTTGCCACAGTTATAATCTCACTGTCCACTACTGT
TACCAAGTTGGAGGACAAGAACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAATTCA
CACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGTGAAACTGATC
CTCATGAACCCAGAGGGCCGGAAGGAAAGCCAAGAACTCATAGTGCAGACAGATGAAGAC
CTCCCAGGTGCTGTTCCCACTGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATATTT
CTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGAGATCACCTAC
AAAGCAGTCAGTTCCTTTGACCCAGAAATAGATTTATCCAATCAGAGTGGAAGAGTTTCA
AAGCTGGGAAATGAAACCCATTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACTCC
TTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAACCAGTTCACC
ACCAAAATATCAGCACCCTCTATGCCAGCTTATGAACTTGAGACACCTTTGAATCAAACT
GACAATACCGTGACAGTCATGCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTGTC
TATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGACAGAAATCTTA
AAGTGCTACCCAGTGCCAATTCACTTCCAGAATGCTTCTCTGCTGAACTCACAGTACTAC
TTTGCTGCAGAATTTCCTGCAGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTGAT
AATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAGCTACAGAATT
TATTTCCAAGCTGCTAGTAGAGCCAATGGGGAAACCAAAATAGACTGTGTCCAAGTGGCC
ACAAAAGGAGCTGCCACTCCGAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATACA
GTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATTTCTTGGAGTT
GTGTTGGTAATGAAGAAAAGGAAACTGGCCAAGAAGCGGAAAGAGACCATGAGCAGCACC
CGACAGGAGATGACTGTGATGGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCACA
AACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAGATCTGTGTCT
TCACCATCGTCCTTCACAATGAAAACAAATACACTGAGCACATCGGTGCCTAATTCCTAT
TACCCAGATGAAACCCACACAATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATACT
TACAAGAAGCGAGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGCTCCACCCCGCCATC
CGGGTGGCAGACCTCCTTCAGCACATCACACAGATGAAGTGTGCGGAGGGCTACGGCTTC
AAGGAGGAATACGAGAGCTTCTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGAAA
GATGAGAACAGAATGAAGAACAGATACGGGAATATCATTGCATACGATCATTCCCGAGTG
AGGCTGCAGACAATAGAAGGAGACACAAACTCAGACTATATCAATGGCAATTATATCGAT
GGTTATCATCGACCCAATCATTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCTAT
GACTTCTGGAGGATGGTGTGGCACGAAAACACTGCAAGTATCATCATGGTGACCAATCTT
GTGGAAGTGGGAAGGGTCAAATGCTGCAAATACTGGCCAGATGACACAGAGATATATAAA
GACATTAAAGTTACCCTAATAGAAACAGAACTACTGGCAGAATATGTGATAAGAACATTT
GCTGTTGAAAAGAGAGGTGTGCATGAAATCCGAGAGATCAGACAGTTTCACTTCACTGGC
TGGCCGGATCATGGGGTCCCCTACCATGCCACCGGCCTGCTGGGATTCGTGCGGCAAGTC
AAGTCCAAGAGCCCGCCCAGTGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAGGG
AGGACTGGCTGTTTCATCGTCATTGATATCATGTTGGACATGGCCGAAAGGGAAGGGGTC
GTAGACATCTACAACTGCGTCAGGGAGCTGCGGTCACGGAGGGTGAACATGGTGCAAACA
GAGGAGCAGTATGTGTTTATCCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACACC
TCTGTGCCTGCTTCCCAAGTTAGGTCTCTGTATTATGACATGAACAAACTGGATCCACAG
ACAAACTCAAGCCAGATTAAAGAGGAATTCCGGACGCTAAACATGGTGACACCAACGCTG
CGAGTAGAGGACTGCAGCATCGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCATG
GACATCCTGCCCCCAGACCGCTGCCTGCCCTTCCTCATCACCATCGATGGGGAGAGCAGC
AACTACATCAATGCTGCCCTCATGGACAGCTATAAACAGCCTTCAGCTTTTATAGTCACC
CAGCATCCTTTGCCAAACACAGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACTGC
ACATCCGTAGTTATGCTAAATGATGTGGATCCTGCCCAGTTGTGTCCACAGTACTGGCCA
GAAAACGGAGTACACAGACACGGCCCCATCCAGGTGGAATTTGTCTCTGCTGACCTGGAA
GAGGACATCATCAGCAGGATATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGATAT
CGGATGGTGCAGCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGGACACACCAGTGTCT
AAGCGCTCCTTCTTGAAGCTCATTCGCCAGGTGGACAAGTGGCAAGAGGAATACAATGGC
GGGGAAGGCCCGACCGTTGTGCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCTGC
GCCATCAGCATCGTATGTGAGATGCTCCGGCACCAGAGAACCGTGGATGTCTTTCACGCT
GTGAAGACACTGAGGAACAACAAGCCCAACATGGTCGACCTCCTGGATCAGTACAAGTTC
TGCTACGAGGTGGCCCTGGAATACTTGAATTCTGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1452 |
| Molecular Weight
| 165058.91 |
| Theoretical pI
| 6.615 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Receptor-type tyrosine-protein phosphatase mu
MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF
KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID
GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK
DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV
KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT
EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL
RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT
QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE
EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG
GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF
CYEVALEYLNSG
|
| External Links |
|---|
| GenBank ID Protein
| 32456 |
| UniProtKB/Swiss-Prot ID
| P28827 |
| UniProtKB/Swiss-Prot Entry Name
| PTPRM_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X58288 |
| GeneCard ID
| PTPRM |
| GenAtlas ID
| PTPRM |
| HGNC ID
| HGNC:9675 |
| References |
|---|
| General References
| Not Available |