Cannabis Compound Database: Showing Protein Tyrosine-protein phosphatase non-receptor type 3 (CDBP04144)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04144

Secondary Accession Numbers

Not Available

Name

Tyrosine-protein phosphatase non-receptor type 3

Description

Not Available

Synonyms

PTP-H1
Protein-tyrosine phosphatase H1

Gene Name

PTPN3

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

GO Classification

Biological Process
negative regulation of membrane protein ectodomain proteolysis
negative regulation of mitotic cell cycle
Cellular Component
cytoskeleton
cytoplasm
internal side of plasma membrane
Component
cytoplasm
cytoskeleton
membrane part
organelle
extrinsic to membrane
non-membrane-bounded organelle
intracellular non-membrane-bounded organelle
cell part
intracellular part
Function
cytoskeletal protein binding
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
protein binding
Molecular Function
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process

Cellular Location

Cell membrane
Cytoplasm
Peripheral membrane protein
Cytoplasmic side
cytoskeleton

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

9q31

SNPs

PTPN3

Gene Sequence

>2742 bp
ATGACCTCCCGGTTACGTGCGTTGGGTGGAAGAATTAATAATATACGCACCTCGGAGTTA
CCCAAAGAGAAAACTCGATCAGAAGTCATTTGCAGCATCCACTTTTTAGATGGCGTGGTA
CAGACCTTTAAAGTTACTAAACAAGACACTGGCCAGGTTCTTCTGGATATGGTGCACAAC
CACCTGGGTGTGACTGAAAAGGAATATTTTGGTTTACAGCATGATGACGACTCCGTGGAC
TCTCCTAGATGGCTGGAAGCAAGCAAAGCCATCAGGAAGCAGTTAAAAGGAGGTTTCCCC
TGTACCCTGCATTTTCGAGTAAGATTTTTTATACCTGATCCCAACACACTGCAGCAAGAA
CAAACCAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACC
TGCCCTCTTAACTCAGCAGTGGTTCTAGCGTCCTATGCCGTACAATCTCATTTTGGAGAC
TATAATTCTTCCATACATCATCCAGGCTATCTTTCCGATAGTCACTTTATACCCGATCAA
AATGAGGACTTTTTAACAAAAGTCGAATCTCTGCATGAGCAGCACAGTGGGCTAAAACAA
TCAGAAGCAGAATCCTGCTATATCAACATAGCGCGGACCCTCGACTTCTATGGAGTAGAA
CTGCACAGTGGTAGGGATCTGCACAATTTAGACCTAATGATTGGAATTGCTTCCGCGGGT
GTTGCTGTGTACCGAAAATACATTTGCACAAGTTTCTATCCTTGGGTGAACATTCTCAAA
ATTTCTTTCAAAAGGAAAAAGTTCTTCATACATCAGCGACAGAAACAGGCTGAATCCAGG
GAACATATTGTGGCCTTCAACATGCTGAATTACCGATCTTGCAAAAACTTGTGGAAATCC
TGTGTTGAGCACCATACGTTCTTTCAGGCAAAGAAGCTACTACCTCAGGAAAAGAATGTT
CTGTCTCAGTACTGGACTATGGGCTCTCGGAACACCAAAAAGTCGGTAAATAACCAATAT
TGCAAAAAGGTGATTGGCGGGATGGTGTGGAACCCAGCCATGCGGAGATCCTTATCAGTG
GAGCACTTAGAAACCAAGAGTCTGCCTTCTCGTTCCCCTCCCATTACTCCCAACTGGCGA
AGTCCTCGGCTCCGGCACGAAATCCGAAAGCCACGCCACTCTTCTGCAGATAACCTTGCA
AATGAAATGACCTACATCACGGAAACGGAAGATGTATTTTACACGTACAAGGGCTCTCTG
GCCCCTCAAGACAGCGATTCTGAAGTTTCTCAGAACCGAAGCCCGCACCAAGAGAGTTTA
TCCGAGAACAATCCGGCACAAAGCTACCTGACCCAGAAGTCATCCAGTTCTGTGTCTCCA
TCTTCAAATGCTCCAGGCTCCTGCTCACCTGACGGCGTTGATCAGCAGCTCTTAGATGAC
TTCCACAGGGTGACCAAAGGGGGCTCCACCGAGGACGCCAGCCAGTACTACTGTGACAAG
AATGATAATGGTGACAGCTACTTAGTCTTGATCCGTATCACACCAGATGAAGATGGAAAA
TTTGGATTTAATCTTAAGGGAGGAGTGGATCAAAAGATGCCTCTTGTGGTATCAAGGATA
AACCCAGAGTCACCTGCGGACACCTGCATTCCTAAGCTGAACGAAGGGGATCAAATCGTG
TTAATCAATGGCCGGGACATCTCAGAACACACGCATGACCAAGTGGTGATGTTCATCAAA
GCCAGCCGGGAGTCCCACTCACGGGAGCTGGCCCTGGTGATCAGGAGGAGAGCTGTCCGC
TCATTTGCTGACTTCAAGTCTGAAGATGAACTGAACCAGCTTTTCCCCGAAGCCATTTTC
CCCATGTGTCCGGAGGGTGGGGACACTTTGGAGGGATCCATGGCACAGCTAAAGAAGGGC
CTCGAAAGCGGGACGGTGCTGATCCAGTTTGAGCAACTCTACAGAAAAAAGCCAGGTTTG
GCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG
CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTAC
GTGAACATGGAAATTCCTGCTGCTAACCTTGTGAACAAGTACATCGCCACTCAGGGGCCC
CTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT
GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGAT
CCCCCCGACGTCATGAACCACGGCGGCTTTCACATCCAGTGTCAGTCAGAGGACTGCACC
ATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA
GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGAC
TTTCTGGAATTTGTAAACTATGTGAGGTCTCTGAGAGTGGACAGCGAGCCCGTCCTAGTT
CACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC
CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAG
CGCGCCATGATGGTGCAGACATCAAGCCAGTACAAGTTTGTGTGTGAAGCGATTCTTCGT
GTGTATGAAGAAGGTTTAGTCCAAATGCTGGATCCTAGTTAA

Protein Properties

Number of Residues

913

Molecular Weight

98897.235

Theoretical pI

6.798

Pfam Domain Function

PDZ (PF00595 )
FERM_M (PF00373 )
Y_phosphatase (PF00102 )
FERM_C (PF09380 )
FERM_N (PF09379 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Tyrosine-protein phosphatase non-receptor type 3
MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN
HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE
QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ
NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG
VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS
CVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSV
EHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL
APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDD
FHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRI
NPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVR
SFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGL
AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGP
LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT
IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLV
HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
VYEEGLVQMLDPS

External Links

GenBank ID Protein

223941876

UniProtKB/Swiss-Prot ID

P26045

UniProtKB/Swiss-Prot Entry Name

PTN3_HUMAN

PDB IDs