| Identification |
|---|
| HMDB Protein ID
| CDBP04141 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tyrosine-protein phosphatase non-receptor type 21 |
| Description
| Not Available |
| Synonyms
|
- Protein-tyrosine phosphatase D1
|
| Gene Name
| PTPN21 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Not Available |
| GO Classification
|
| Cellular Component |
| cytoskeleton |
| cytoplasm |
| Component |
| cytoskeleton |
| organelle |
| non-membrane-bounded organelle |
| intracellular non-membrane-bounded organelle |
| Function |
| binding |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| Molecular Function |
| protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasm
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q31.3 |
| SNPs
| PTPN21 |
| Gene Sequence
|
>3525 bp
ATGCCACTGCCATTTGGGTTGAAACTGAAACGCACCCGGCGCTACACGGTGTCCAGCAAG
AGTTGCCTGGTTGCCCGGATCCAACTGCTTAATAACGAGTTTGTGGAGTTCACCCTGTCC
GTGGAGAGCACTGGCCAGGAAAGCCTCGAGGCCGTGGCCCAGAGGCTGGAGCTGCGGGAG
GTCACTTACTTCAGCCTCTGGTACTACAACAAGCAAAATCAGCGCCGGTGGGTAGATTTG
GAAAAACCTTTGAAGAAGCAGCTGGATAAATATGCATTGGAACCTACCGTCTATTTTGGA
GTGGTGTTTTATGTGCCTTCAGTTTCTCAGCTGCAGCAGGAGATTACCAGGTATCAGTAT
TATCTGCAACTGAAGAAAGATATCTTGGAAGGAAGTATTCCTTGTACCTTAGAACAAGCA
ATTCAGCTAGCAGGCTTAGCTGTTCAAGCGGATTTTGGTGACTTTGATCAGTATGAATCC
CAGGACTTTCTTCAGAAATTTGCCTTGTTTCCTGTGGGATGGTTACAAGATGAAAAAGTA
TTGGAAGAAGCAACCCAAAAAGTGGCCTTACTACATCAGAAATACAGAGGGCTCACAGCT
CCTGATGCTGAAATGCTGTACATGCAGGAGGTAGAGAGAATGGATGGCTATGGAGAAGAG
AGCTACCCTGCTAAGGATAGCCAAGGAAGTGACATATCCATTGGAGCGTGTCTTGAAGGT
ATCTTTGTGAAACACAAGAATGGAAGGCATCCTGTGGTATTTAGGTGGCATGACATTGCC
AACATGTCCCACAACAAGTCCTTTTTTGCATTAGAGCTGGCAAATAAAGAGGAGACCATT
CAATTTCAAACTGAAGACATGGAAACAGCAAAATACATTTGGAGACTCTGTGTTGCGCGA
CACAAGTTTTACAGACTAAACCAGTGTAACCTGCAAACTCAGACTGTCACAGTGAACCCA
ATCAGGAGGAGGTCTTCTTCAAGGATGTCTCTGCCTAAACCCCAGCCCTACGTGATGCCT
CCCCCACCGCAGTTGCACTATAATGGACATTATACAGAACCATATGCTTCTTCCCAAGAT
AACCTCTTTGTGCCCAACCAGAACGGATACTACTGTCACTCTCAGACAAGCTTGGATAGA
GCCCAGATTGACTTCAACGGTCGGATCCGTAATGGCAGTGTCTACAGTGCACACAGCACC
AACTCCTTAAATAATCCTCAGCCCTACTTGCAGCCCTCGCCGATGTCGTCCAACCCTAGC
ATCACCGGGAGTGACGTCATGAGGCCTGACTACCTCCCGTCCCATCGGCACAGCGCCGTG
ATACCCCCGTCCTACCGCCCCACCCCAGACTATGAGACTGTGATGAAGCAGCTCAACAGG
GGCCTGGTGCATGCGGAACGGCAGAGCCACTCGCTGCGAAACCTCAACATCGGCAGCTCG
TACGCCTACAGCAGGCCCGCGGCGCTGGTCTACAGCCAGCCCGAGATCCGCGAGCACGCA
CAGCTCCCCTCGCCAGCGGCCGCACACTGCCCGTTCAGCCTGAGCTACAGCTTCCACAGC
CCGTCTCCCTACCCCTACCCTGCCGAGCGGCGGCCCGTGGTGGGCGCGGTCAGCGTGCCG
GAGCTGACCAATGCGCAGCTGCAGGCGCAGGACTACCCGTCTCCCAACATCATGCGGACG
CAGGTGTACCGGCCACCCCCACCCTACCCGCCCCCCAGGCCCGCCAACAGCACGCCAGAC
CTGTCCCGCCACCTTTACATCAGCAGCAGCAACCCCGACCTCATCACGCGGCGCGTGCAC
CACTCGGTGCAAACGTTCCAGGAGGACAGCCTGCCCGTGGCGCACTCGCTGCAGGAGGTC
AGCGAGCCCCTCACCGCCGCGCGCCACGCGCAGCTGCACAAACGGAACAGCATCGAGGTG
GCCGGGCTCAGCCACGGCCTGGAGGGCCTGCGGCTCAAGGAGCGCACCCTATCCGCGTCG
GCGGCAGAGGTGGCGCCGCGAGCCGTCTCGGTGGGCTCCCAGCCCAGCGTTTTCACCGAG
AGGACACAGCGAGAAGGGCCGGAGGAGGCGGAGGGCTTGAGGTACGGCCATAAGAAGTCC
CTGTCGGACGCCACCATGCTAATCCACAGCAGCGAGGAGGAGGAGGACGAGGACTTCGAG
GAGGAGAGCGGGGCCCGGGCGCCCCCTGCACGTGCGCGCGAGCCTCGGCCCGGCCTGGCC
CAGGACCCACCTGGCTGCCCTCGCGTCCTGCTCGCCGGGCCCCTGCACATCCTGGAGCCC
AAGGCCCACGTCCCAGACGCGGAGAAGAGGATGATGGACAGCAGCCCCGTCCGCACGACC
GCAGAGGCCCAGCGGCCCTGGAGAGACGGGCTGCTGATGCCCTCCATGTCGGAGTCCGAC
CTCACCACGTCAGGCCGCTACCGAGCCCGGAGGGACTCTCTGAAGAAAAGGCCGGTGTCG
GACCTTCTCTCTGGGAAGAAGAACATCGTGGAAGGGCTCCCGCCTCTAGGGGGAATGAAA
AAGACTCGAGTAGATGCAAAAAAAATTGGTCCTCTTAAACTGGCTGCCCTAAATGGACTC
TCCCTATCTCGAGTGCCTCTGCCTGATGAAGGAAAGGAAGTGGCTACCAGAGCAACGAAT
GATGAAAGGTGTAAAATTCTGGAACAACGATTAGAACAAGGAATGGTATTCACAGAATAT
GAAAGAATTCTTAAGAAACGGCTAGTTGATGGGGAGTGCTCAACAGCACGACTCCCTGAA
AATGCAGAAAGAAATCGATTCCAAGATGTTCTTCCTTATGATGATGCGAGAGTGGAGTTG
GTCCCAACTAAAGAAAACAACACTGGTTACATCAACGCATCACATATTAAGGTCTCTGTC
AGTGGAATCGAATGGGATTATATTGCCACACAGGGACCATTACAGAATACCTGTCAAGAT
TTTTGGCAGATGGTATGGGAACAGGGAATTGCAATTATAGCAATGGTGACAGCAGAAGAG
GAGGGTGGAAGGGAGAAGAGCTTTAGGTACTGGCCACGACTTGGTTCCAGGCACAACACT
GTCACCTATGGAAGGTTTAAGATCACGACCCGGTTCCGCACAGACTCTGGCTGCTATGCC
ACCACAGGCCTGAAGATGAAGCACCTCCTTACCGGGCAAGAGAGGACCGTCTGGCACCTC
CAATACACAGACTGGCCTGAACATGGCTGTCCAGAAGACCTCAAGGGATTTTTATCATAT
CTTGAAGAGATCCAGTCTGTTCGACGCCATACAAATAGCACAAGTGATCCCCAAAGCCCC
AACCCTCCGTTGTTGGTCCACTGCAGTGCTGGGGTAGGAAGGACTGGCGTGGTGATTTTG
TCGGAGATCATGATCGCCTGCCTGGAACACAATGAGGTGCTGGACATCCCGAGAGTGCTG
GACATGCTGAGGCAACAGAGAATGATGCTGGTGCAGACTCTCTGCCAGTACACATTTGTG
TACAGAGTCCTCATCCAGTTCCTGAAAAGCTCCAGGCTCATCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1174 |
| Molecular Weight
| 133279.965 |
| Theoretical pI
| 7.897 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tyrosine-protein phosphatase non-receptor type 21
MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELRE
VTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQY
YLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV
LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEG
IFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVAR
HKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQD
NLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS
ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSS
YAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVP
ELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVH
HSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSAS
AAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFE
EESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTT
AEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK
KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEY
ERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSV
SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNT
VTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSY
LEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVL
DMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI
|
| External Links |
|---|
| GenBank ID Protein
| 532056 |
| UniProtKB/Swiss-Prot ID
| Q16825 |
| UniProtKB/Swiss-Prot Entry Name
| PTN21_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X79510 |
| GeneCard ID
| PTPN21 |
| GenAtlas ID
| PTPN21 |
| HGNC ID
| HGNC:9651 |
| References |
|---|
| General References
| Not Available |