| Identification |
|---|
| HMDB Protein ID
| CDBP04125 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity protein phosphatase 9 |
| Description
| Not Available |
| Synonyms
|
- MAP kinase phosphatase 4
- MKP-4
- Mitogen-activated protein kinase phosphatase 4
|
| Gene Name
| DUSP9 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Inactivates MAP kinases. Has a specificity for the ERK family.
|
| GO Classification
|
| Biological Process |
| JNK cascade |
| peptidyl-tyrosine dephosphorylation |
| Cellular Component |
| cytosol |
| endoplasmic reticulum |
| nucleus |
| Function |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| map kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| MAP kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | MAPK signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xq28 |
| SNPs
| DUSP9 |
| Gene Sequence
|
>1155 bp
ATGGAGGGTCTGGGCCGCTCGTGCCTGTGGCTGCGTCGGGAGCTGTCGCCCCCGCGGCCG
CGGCTCCTGCTCCTGGACTGCCGCAGCCGCGAGCTGTACGAGTCGGCGCGCATCGGTGGG
GCGCTGAGCGTGGCCCTGCCGGCGCTCCTGCTGCGCCGCCTGCGGAGGGGCAGCCTGTCG
GTGCGCGCGCTCCTGCCTGGGCCGCCGCTGCAGCCGCCCCCGCCTGCCCCCGTGCTCCTG
TACGACCAGGGCGGGGGCCGGCGCCGGCGCGGGGAGGCCGAGGCCGAGGCCGAGGAGTGG
GAGGCCGAGTCGGTGCTGGGCACCCTGCTGCAGAAGCTGCGAGAGGAAGGCTACCTGGCC
TACTACCTCCAGGGAGGCTTCAGCAGATTCCAGGCCGAGTGCCCTCACCTGTGTGAGACC
AGCCTTGCTGGCCGTGCCGGCTCCAGCATGGCGCCGGTGCCCGGTCCAGTGCCCGTGGTG
GGGTTGGGCAGCCTGTGCCTGGGCTCCGACTGCTCTGATGCGGAATCCGAGGCTGACCGC
GACTCCATGAGCTGTGGCCTGGATTCGGAGGGTGCCACACCCCCACCAGTGGGGCTGCGG
GCATCCTTCCCTGTCCAGATCCTGCCCAACCTCTATCTGGGCAGTGCCCGGGATTCCGCC
AATTTGGAGAGCCTGGCCAAACTGGGCATCCGCTACATCCTCAATGTCACCCCCAACCTC
CCAAACTTCTTCGAGAAGAATGGTGACTTTCACTACAAGCAGATCCCCATCTCCGACCAC
TGGAGCCAGAACCTGTCGCGGTTCTTTCCGGAGGCCATTGAGTTCATTGATGAGGCCTTG
TCCCAGAACTGCGGGGTGCTCGTCCACTGCTTGGCGGGGGTCAGCCGTTCTGTCACCGTC
ACTGTGGCCTACCTCATGCAGAAGCTCCACCTCTCTCTCAACGATGCCTATGACCTGGTC
AAGAGGAAGAAGTCTAACATCTCCCCCAACTTCAACTTCATGGGGCAGTTGCTGGACTTT
GAGCGCAGCTTGCGGCTGGAGGAGCGCCACTCGCAGGAGCAGGGCAGTGGGGGGCAGGCA
TCTGCGGCCTCCAACCCGCCCTCCTTCTTCACCACCCCCACCAGTGATGGCGCCTTCGAG
CTGGCCCCCACCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 384 |
| Molecular Weight
| 41867.055 |
| Theoretical pI
| 6.117 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dual specificity protein phosphatase 9
MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRRGSLS
VRALLPGPPLQPPPPAPVLLYDQGGGRRRRGEAEAEAEEWEAESVLGTLLQKLREEGYLA
YYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVVGLGSLCLGSDCSDAESEADR
DSMSCGLDSEGATPPPVGLRASFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNL
PNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTV
TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEERHSQEQGSGGQA
SAASNPPSFFTTPTSDGAFELAPT
|
| External Links |
|---|
| GenBank ID Protein
| 4503421 |
| UniProtKB/Swiss-Prot ID
| Q99956 |
| UniProtKB/Swiss-Prot Entry Name
| DUS9_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001395.2 |
| GeneCard ID
| DUSP9 |
| GenAtlas ID
| DUSP9 |
| HGNC ID
| HGNC:3076 |
| References |
|---|
| General References
| Not Available |