Showing Protein Dual specificity protein phosphatase 7 (CDBP04123)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP04123
Secondary Accession Numbers Not Available
Name Dual specificity protein phosphatase 7
Description Not Available
Synonyms
  1. Dual specificity protein phosphatase PYST2
Gene Name DUSP7
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.
GO Classification
Biological Process
MyD88-dependent toll-like receptor signaling pathway
stress-activated MAPK cascade
Toll signaling pathway
toll-like receptor 1 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
nerve growth factor receptor signaling pathway
peptidyl-tyrosine dephosphorylation
innate immune response
Cellular Component
cytosol
nucleoplasm
Function
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
map kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
Molecular Function
MAP kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 3
Locus 3p21
SNPs DUSP7
Gene Sequence 
>1107 bp
ATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCC
TTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACGGCC
ATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATC
CGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCC
ACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCCGCC
TCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTC
CAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGAGCACTGCGAGACCAACGTGGAC
AGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTGCGC
ATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAG
TCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTAC
CTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGCATC
AAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTC
ACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCT
GAGGCCATCAGCTTCATTGACGAAGCCCGCTCCAAGAAGTGTGGTGTCCTGGTGCACTGC
CTGGCAGGCATCAGCCGCTCAGTGACGGTCACTGTGGCCTATCTGATGCAGAAGATGAAC
CTGTCACTCAACGACGCCTACGACTTTGTCAAGAGGAAAAAGTCCAACATCTCGCCCAAC
TTCAACTTCATGGGGCAGCTGCTGGACTTTGAGCGGACGCTGGGGCTAAGCAGCCCGTGC
GACAACCACGCGTCGAGTGAGCAGCTCTACTTTTCCACGCCCACCAACCACAACCTGTTC
CCACTCAATACGCTGGAGTCCACGTGA
Protein Properties
Number of Residues 368
Molecular Weight 44956.0
Theoretical pI 6.091
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Dual specificity protein phosphatase 7
MPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPI
RSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYL
QGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATE
SDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEF
TYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMN
LSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHASSEQLYFSTPTNHNLF
PLNTLEST
GenBank ID Protein 21779999
UniProtKB/Swiss-Prot ID Q16829
UniProtKB/Swiss-Prot Entry Name DUS7_HUMAN
PDB IDs Not Available
GenBank Gene ID AF508727
GeneCard ID DUSP7
GenAtlas ID DUSP7
HGNC ID HGNC:3073
References
General References Not Available