Showing Protein Dual specificity protein phosphatase 4 (CDBP04120)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP04120
Secondary Accession Numbers Not Available
Name Dual specificity protein phosphatase 4
Description Not Available
Synonyms
  1. Dual specificity protein phosphatase hVH2
  2. MAP kinase phosphatase 2
  3. MKP-2
  4. Mitogen-activated protein kinase phosphatase 2
Gene Name DUSP4
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
GO Classification
Biological Process
response to organic substance
innate immune response
endoderm formation
MyD88-dependent toll-like receptor signaling pathway
stress-activated MAPK cascade
Toll signaling pathway
toll-like receptor 1 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
nerve growth factor receptor signaling pathway
peptidyl-tyrosine dephosphorylation
Cellular Component
nucleoplasm
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
map kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
Molecular Function
MAP kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/threonine phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location 8
Locus 8p12-p11
SNPs DUSP4
Gene Sequence 
>1185 bp
ATGGTGACGATGGAGGAGCTGCGGGAGATGGACTGCAGTGTGCTCAAAAGGCTGATGAAC
CGGGACGAGAATGGCGGCGGCGCGGGCGGCAGCGGCAGCCACGGCACCCTGGGGCTGCCG
AGCGGCGGCAAGTGCCTGCTGCTGGACTGCAGACCGTTCCTGGCGCACAGCGCGGGCTAC
ATCCTAGGTTCGGTCAACGTGCGCTGTAACACCATCGTGCGGCGGCGGGCTAAGGGCTCC
GTGAGCCTGGAGCAGATCCTGCCCGCCGAGGAGGAGGTACGCGCCCGCTTGCGCTCCGGC
CTCTACTCGGCGGTCATCGTCTACGACGAGCGCAGCCCGCGCGCCGAGAGCCTCCGCGAG
GACAGCACCGTGTCGCTGGTGGTGCAGGCGCTGCGCCGCAACGCCGAGCGCACCGACATC
TGCCTGCTCAAAGGCGGCTATGAGAGGTTTTCCTCCGAGTACCCAGAATTCTGTTCTAAA
ACCAAGGCCCTGGCAGCCATCCCACCCCCGGTTCCCCCCAGCGCCACAGAGCCCTTGGAC
CTGGGCTGCAGCTCCTGTGGGACCCCACTACACGACCAGGGGGGTCCTGTGGAGATCCTT
CCCTTCCTCTACCTCGGCAGTGCCTACCATGCTGCCCGGAGAGACATGCTGGACGCCCTG
GGCATCACGGCTCTGTTGAATGTCTCCTCGGACTGCCCAAACCACTTTGAAGGACACTAT
CAGTACAAGTGCATCCCAGTGGAAGATAACCACAAGGCCGACATCAGCTCCTGGTTCATG
GAAGCCATAGAGTACATCGATGCCGTGAAGGACTGCCGTGGGCGCGTGCTGGTGCACTGC
CAGGCGGGCATCTCGCGGTCGGCCACCATCTGCCTGGCCTACCTGATGATGAAGAAACGG
GTGAGGCTGGAGGAGGCCTTCGAGTTCGTTAAGCAGCGCCGCAGCATCATCTCGCCCAAC
TTCAGCTTCATGGGGCAGCTGCTGCAGTTCGAGTCCCAGGTGCTGGCCACGTCCTGTGCT
GCGGAGGCTGCTAGCCCCTCGGGACCCCTGCGGGAGCGGGGCAAGACCCCCGCCACCCCC
ACCTCGCAGTTCGTCTTCAGCTTTCCGGTCTCCGTGGGCGTGCACTCGGCCCCCAGCAGC
CTGCCCTACCTGCACAGCCCCATCACCACCTCTCCCAGCTGTTAG
Protein Properties
Number of Residues 394
Molecular Weight 42952.635
Theoretical pI 7.36
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Dual specificity protein phosphatase 4
MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY
ILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLRE
DSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLD
LGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHY
QYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKR
VRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATP
TSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC
GenBank ID Protein 189054566
UniProtKB/Swiss-Prot ID Q13115
UniProtKB/Swiss-Prot Entry Name DUS4_HUMAN
PDB IDs
GenBank Gene ID AK314820
GeneCard ID DUSP4
GenAtlas ID DUSP4
HGNC ID HGNC:3070
References
General References Not Available