Cannabis Compound Database: Showing Protein Dual specificity protein phosphatase 1 (CDBP04117)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP04117

Secondary Accession Numbers

Not Available

Name

Dual specificity protein phosphatase 1

Description

Not Available

Synonyms

Dual specificity protein phosphatase hVH1
MAP kinase phosphatase 1
MKP-1
Mitogen-activated protein kinase phosphatase 1
Protein-tyrosine phosphatase CL100

Gene Name

DUSP1

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle (By similarity).

GO Classification

Biological Process
response to light stimulus
response to calcium ion
response to oxidative stress
response to testosterone stimulus
response to glucocorticoid stimulus
regulation of apoptotic process
endoderm formation
response to estradiol stimulus
response to hydrogen peroxide
response to cAMP
intracellular signal transduction
cell cycle
positive regulation of apoptotic process
cellular response to hormone stimulus
response to retinoic acid
Cellular Component
nucleoplasm
Function
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
map kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
Molecular Function
MAP kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/threonine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process

Cellular Location

Cytoplasmic

Pathways

Name	SMPDB/Pathwhiz	KEGG
MAPK signaling pathway	Not Available
Serotonergic synapse	Not Available

Gene Properties

Chromosome Location

Locus

5q34

SNPs

DUSP1

Gene Sequence

>1104 bp
ATGGTCATGGAAGTGGGCACCCTGGACGCTGGAGGCCTGCGGGCGCTGCTGGGGGAGCGA
GCGGCGCAATGCCTGCTGCTGGACTGCCGCTCCTTCTTCGCTTTCAACGCCGGCCACATC
GCCGGCTCTGTCAACGTGCGCTTCAGCACCATCGTGCGGCGCCGGGCCAAGGGCGCCATG
GGCCTGGAGCACATCGTGCCCAACGCCGAGCTCCGCGGCCGCCTGCTGGCCGGCGCCTAC
CACGCCGTGGTGTTGCTGGACGAGCGCAGCGCCGCCCTGGACGGCGCCAAGCGCGACGGC
ACCCTGGCCCTGGCGGCCGGCGCGCTCTGCCGCGAGGCGCGCGCCGCGCAAGTCTTCTTC
CTCAAAGGAGGATACGAAGCGTTTTCGGCTTCCTGCCCGGAGCTGTGCAGCAAACAGTCG
ACCCCCATGGGGCTCAGCCTTCCCCTGAGTACTAGCGTCCCTGACAGCGCGGAATCTGGG
TGCAGTTCCTGCAGTACCCCACTCTACGATCAGGGTGGCCCGGTGGAAATCCTGCCCTTT
CTGTACCTGGGCAGTGCGTATCACGCTTCCCGCAAGGACATGCTGGATGCCTTGGGCATA
ACTGCCTTGATCAACGTCTCAGCCAATTGTCCCAACCATTTTGAGGGTCACTACCAGTAC
AAGAGCATCCCTGTGGAGGACAACCACAAGGCAGACATCAGCTCCTGGTTCAACGAGGCC
ATTGACTTCATAGACTCCATCAAGAATGCTGGAGGAAGGGTGTTTGTCCACTGCCAGGCA
GGCATTTCCCGGTCAGCCACCATCTGCCTTGCTTACCTTATGAGGACTAATCGAGTCAAG
CTGGACGAGGCCTTTGAGTTTGTGAAGCAGAGGCGAAGCATCATCTCTCCCAACTTCAGC
TTCATGGGCCAGCTGCTGCAGTTTGAGTCCCAGGTGCTGGCTCCGCACTGTTCGGCAGAG
GCTGGGAGCCCCGCCATGGCTGTGCTCGACCGAGGCACCTCCACCACCACCGTGTTCAAC
TTCCCCGTCTCCATCCCTGTCCACTCCACGAACAGTGCGCTGAGCTACCTTCAGAGCCCC
ATTACGACCTCTCCCAGCTGCTGA

Protein Properties

Number of Residues

367

Molecular Weight

39297.37

Theoretical pI

7.195

Pfam Domain Function

Rhodanese (PF00581 )
DSPc (PF00782 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Dual specificity protein phosphatase 1
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM
GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF
LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF
LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA
IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS
FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP
ITTSPSC

External Links

GenBank ID Protein

18490273

UniProtKB/Swiss-Prot ID

P28562

UniProtKB/Swiss-Prot Entry Name

DUS1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

BC022463

GeneCard ID