Showing Protein Dual specificity protein phosphatase 19 (CDBP04116)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP04116
Secondary Accession Numbers Not Available
Name Dual specificity protein phosphatase 19
Description Not Available
Synonyms
  1. Dual specificity phosphatase TS-DSP1
  2. LMW-DSP3
  3. Low molecular weight dual specificity phosphatase 3
  4. Protein phosphatase SKRP1
  5. SAPK pathway-regulating phosphatase 1
  6. Stress-activated protein kinase pathway-regulating phosphatase 1
Gene Name DUSP19
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Has a dual specificity toward Ser/Thr and Tyr-containing proteins.
GO Classification
Biological Process
negative regulation of JNK cascade
negative regulation of JUN kinase activity
inactivation of MAPK activity
positive regulation of JNK cascade
positive regulation of JUN kinase activity
peptidyl-tyrosine dephosphorylation
JNK cascade
Cellular Component
cytoplasm
Function
phosphoprotein phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
Molecular Function
mitogen-activated protein kinase kinase kinase binding
protein kinase activator activity
protein kinase inhibitor activity
protein tyrosine/threonine phosphatase activity
protein tyrosine phosphatase activity
JUN kinase phosphatase activity
MAP-kinase scaffold activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location 2
Locus 2q32.1
SNPs DUSP19
Gene Sequence 
>654 bp
ATGTACTCCCTTAACCAGGAAATTAAAGCATTCTCCCGGAATAATCTCAGGAAGCAATGC
ACCAGGGTGACAACGCTAACTGGAAAGAAAATTATAGAAACATGGAAAGATGCCAGAATT
CATGTTGTGGAAGAAGTAGAGCCGAGCAGTGGGGGTGGTTGTGGTTATGTGCAGGACCTT
AGCTCGGACCTGCAAGTTGGCGTTATTAAGCCATGGTTGCTCCTAGGGTCACAAGATGCT
GCTCATGATTTGGATACACTGAAAAAGAATAAGGTGACTCATATTCTTAATGTTGCATAT
GGAGTTGAAAATGCTTTCCTCAGTGACTTTACATATAAGAGCATTTCTATATTGGATCTG
CCTGAAACCAACATCCTGTCTTATTTTCCAGAATGTTTTGAATTTATTGAAGAAGCAAAA
AGAAAAGATGGAGTGGTTCTTGTTCATTGTAATGCAGGCGTTTCCAGGGCTGCTGCAATT
GTAATAGGTTTCCTGATGAATTCTGAACAAACCTCATTTACCAGTGCTTTTTCTTTGGTG
AAAAATGCAAGACCTTCCATATGTCCAAATTCTGGCTTCATGGAGCAGCTTCGTACATAT
CAAGAGGGCAAAGAAAGCAATAAGTGTGACAGAATACAGGAGAACAGTTCATGA
Protein Properties
Number of Residues 217
Molecular Weight 18295.625
Theoretical pI 8.074
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Dual specificity protein phosphatase 19
MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDL
SSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDL
PETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLV
KNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS
GenBank ID Protein 18146956
UniProtKB/Swiss-Prot ID Q8WTR2
UniProtKB/Swiss-Prot Entry Name DUS19_HUMAN
PDB IDs
GenBank Gene ID AB038770
GeneCard ID DUSP19
GenAtlas ID DUSP19
HGNC ID HGNC:18894
References
General References Not Available