| Identification |
|---|
| HMDB Protein ID
| CDBP04109 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cyclin-dependent kinase inhibitor 3 |
| Description
| Not Available |
| Synonyms
|
- CDK2-associated dual-specificity phosphatase
- Cyclin-dependent kinase interactor 1
- Cyclin-dependent kinase-interacting protein 2
- Kinase-associated phosphatase
|
| Gene Name
| CDKN3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
|
| GO Classification
|
| Biological Process |
| G1/S transition of mitotic cell cycle |
| regulation of cyclin-dependent protein kinase activity |
| negative regulation of cell proliferation |
| cell cycle arrest |
| Cellular Component |
| perinuclear region of cytoplasm |
| Function |
| phosphoprotein phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| phosphoric monoester hydrolase activity |
| Molecular Function |
| protein tyrosine/serine/threonine phosphatase activity |
| protein serine/threonine phosphatase activity |
| protein tyrosine phosphatase activity |
| Process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
| biopolymer metabolism |
| biopolymer modification |
| protein modification |
| physiological process |
| metabolism |
| macromolecule metabolism |
| phosphorus metabolic process |
| phosphate metabolic process |
|
| Cellular Location
|
- Cytoplasmic
- Cytoplasm
- perinuclear region
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q22 |
| SNPs
| CDKN3 |
| Gene Sequence
|
>639 bp
ATGAAGCCGCCCAGTTCAATACAAACAAGTGAGTTTGACTCATCAGATGAAGAGCCTATT
GAAGATGAACAGACTCCAATTCATATATCACGGCTATCTTTGTCACGAGTGAATTGTTCT
CAGTTTCTCGGTTTATGTGCTCTTCCAGGTTGTAAATTTAAAGATGTTAGAAGAAATGTC
CAAAAAGATACAGAAGAACTAAAGAGCTGTGGTATACAAGACATATTTGTTTTCTACACC
AGAGGGGAACTGTCAAAATATAGAGTCCCAAACCTTCTGGATCTCTACCAGCAATGTGGA
ATTATCACCCATCATCATCCAATCGCAGATGGAGGGACTCCTGACATAGCCAGCTGCTGT
GAAATAATGGAAGAGCTTACAACCTGCCTTAAAAATTACCGAAAAACCTTAATACACTGC
TATGGAGGACTTGGGAGATCTTGTCTTGTAGCTGCTTGTCTCCTACTATACCTGTCTGAC
ACAATATCACCAGAGCAAGCCATAGACAGCCTGCGAGACCTAAGAGGATCCGGGGCAATA
CAGACCATCAAGCAATACAATTATCTTCATGAGTTTCGGGACAAATTAGCTGCACATCTA
TCATCAAGAGATTCACAATCAAGATCTGTATCAAGATAA
|
| Protein Properties |
|---|
| Number of Residues
| 212 |
| Molecular Weight
| 19358.945 |
| Theoretical pI
| 8.021 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cyclin-dependent kinase inhibitor 3
MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNV
QKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCC
EIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAI
QTIKQYNYLHEFRDKLAAHLSSRDSQSRSVSR
|
| External Links |
|---|
| GenBank ID Protein
| 12734644 |
| UniProtKB/Swiss-Prot ID
| Q16667 |
| UniProtKB/Swiss-Prot Entry Name
| CDKN3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF213033 |
| GeneCard ID
| CDKN3 |
| GenAtlas ID
| CDKN3 |
| HGNC ID
| HGNC:1791 |
| References |
|---|
| General References
| Not Available |