| Identification |
|---|
| HMDB Protein ID
| CDBP04108 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity protein phosphatase CDC14B |
| Description
| Not Available |
| Synonyms
|
- CDC14 cell division cycle 14 homolog B
- SubName: cDNA FLJ44424 fis, clone UTERU2005621, highly similar to Dual specificity protein phosphatase CDC14B (EC 3.1.3.48)
|
| Gene Name
| CDC14B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
|
| GO Classification
|
| Biological Process |
| activation of anaphase-promoting complex activity |
| DNA repair |
| G2/M transition DNA damage checkpoint |
| Cellular Component |
| nucleolus |
| nucleoplasm |
| nuclear membrane |
| Function |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| Molecular Function |
| protein tyrosine/serine/threonine phosphatase activity |
| protein serine/threonine phosphatase activity |
| protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasmic
- Nucleus
- Nucleus
- nucleolus
- nucleoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Cell cycle | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q22.3 |
| SNPs
| CDC14B |
| Gene Sequence
|
>1497 bp
ATGAAGCGGAAAAGCGAGCGGCGGTCGAGCTGGGCCGCCGCGCCCCCCTGCTCGCGGCGC
TGCTCGTCGACCTCGCCGGGTGTGAAGAAGATCCGCAGCTCCACGCAGCAAGACCCGCGC
CGCCGGGACCCCCAGGACGACGTGTACCTGGACATCACCGATCGCCTTTGTTTTGCCATT
CTCTACAGCAGACCAAAGAGTGCATCAAATGTACATTATTTCAGCATAGATAATGAACTT
GAATATGAGAACTTCTACGCAGATTTTGGACCACTCAATCTGGCAATGGTTTACAGATAT
TGTTGCAAGATCAATAAGAAATTAAAGTCCATTACAATGTTAAGGAAGAAAATTGTTCAT
TTTACTGGCTCTGATCAGAGAAAACAAGCAAATGCTGCCTTCCTTGTTGGATGCTACATG
GTTATATATTTGGGGAGAACCCCAGAAGAAGCATATAGAATATTAATCTTTGGAGAGACA
TCCTATATTCCTTTCAGAGATGCTGCCTATGGAAGTTGCAATTTCTACATTACACTTCTT
GACTGTTTTCATGCAGTAAAGAAGGCAATGCAGTATGGCTTCCTTAATTTCAACTCATTT
AACCTTGATGAATATGAACACTATGAAAAAGCAGAAAATGGAGATTTAAATTGGATAATA
CCAGACCGATTTATTGCCTTCTGTGGACCTCATTCAAGAGCCAGACTTGAAAGTGGTTAC
CACCAACATTCTCCTGAGACTTATATTCAATATTTTAAGAATCACAATGTTACTACCATT
ATTCGTCTGAATAAAAGGATGTATGATGCCAAACGCTTTACGGATGCTGGCTTCGATCAC
CATGATCTTTTCTTTGCGGATGGCAGCACCCCTACTGATGCCATTGTCAAAGAATTCCTA
GATATCTGTGAAAATGCTGAGGGTGCCATTGCAGTACATTGCAAAGCTGGCCTTGGTCGC
ACGGGCACTCTGATAGCCTGCTACATCATGAAGCATTACAGGATGACAGCAGCCGAGACC
ATTGCGTGGGTCAGGATCTGCAGACCTGGCTCGGTGATTGGGCCTCAGCAGCAGTTTTTG
GTGATGAAGCAAACCAACCTCTGGCTGGAAGGGGACTATTTTCGTCAGAAGTTAAAGGGG
CAGGAGAATGGACAACACAGAGCAGCCTTCTCCAAACTTCTCTCTGGCGTTGATGACATT
TCCATAAATGGGGTCGAGAATCAAGATCAGCAAGAACCCGAACCGTACAGTGATGATGAC
GAAATCAATGGAGTGACACAAGGTGATAGACTTCGGGCCTTGAAAAGCAGAAGACAATCC
AAAACAAACGCTATTCCTCTCACAGTAATTCTTCAATCCAGTGTTCAGAGCTGTAAAACA
TCTGAACCTAACATTTCTGGCAGTGCAGGCATTACTAAAAGAACCACCAGATCTGCTTCA
AGGAAAAGCAGTGTTAAAAGTCTCTCCATTTCAAGGACTAAAACAGTCTTGCGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 498 |
| Molecular Weight
| 52310.04 |
| Theoretical pI
| 8.651 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dual specificity protein phosphatase CDC14B
MKRKSERRSSWAAAPPCSRRCSSTSPGVKKIRSSTQQDPRRRDPQDDVYLDITDRLCFAI
LYSRPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIVH
FTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFGETSYIPFRDAAYGSCNFYITLL
DCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGY
HQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFL
DICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFL
VMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPEPYSDDD
EINGVTQGDRLRALKSRRQSKTNAIPLTVILQSSVQSCKTSEPNISGSAGITKRTTRSAS
RKSSVKSLSISRTKTVLR
|
| External Links |
|---|
| GenBank ID Protein
| 15451936 |
| UniProtKB/Swiss-Prot ID
| O60729 |
| UniProtKB/Swiss-Prot Entry Name
| CC14B_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_033331.2 |
| GeneCard ID
| CDC14B |
| GenAtlas ID
| CDC14B |
| HGNC ID
| HGNC:1719 |
| References |
|---|
| General References
| Not Available |