Cannabis Compound Database: Showing Protein Dual specificity protein phosphatase CDC14A (CDBP04107)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP04107

Secondary Accession Numbers

Not Available

Name

Dual specificity protein phosphatase CDC14A

Description

Not Available

Synonyms

CDC14 cell division cycle 14 homolog A

Gene Name

CDC14A

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.

GO Classification

Biological Process
cell cycle
cell division
cell proliferation
peptidyl-tyrosine dephosphorylation
Cellular Component
centrosome
spindle
cytoplasm
nucleus
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
Molecular Function
phosphoprotein phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
Process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
phosphorus metabolic process

Cellular Location

Nucleus
Cytoplasm
Cytoplasm
cytoskeleton
cytoskeleton
spindle
centrosome

Pathways

Name	SMPDB/Pathwhiz	KEGG
Cell cycle	Not Available

Gene Properties

Chromosome Location

Locus

1p21

SNPs

CDC14A

Gene Sequence

>1785 bp
ATGGCAGCGGAGTCAGGGGAACTAATCGGGGCTTGTGAGTTCATGAAAGATCGGTTATAT
TTTGCTACTTTAAGGAATAGACCAAAAAGCACAGTAAATACCCACTATTTCTCCATCGAT
GAGGAGCTGGTCTATGAAAATTTCTATGCAGATTTTGGACCGCTGAACTTGGCAATGGTG
TACAGATATTGCTGCAAACTAAACAAGAAACTAAAATCATACAGTTTGTCAAGAAAGAAA
ATAGTGCACTACACCTGTTTTGACCAACGGAAAAGAGCAAATGCAGCATTTTTGATAGGT
GCCTATGCAGTAATCTATTTAAAGAAGACACCAGAAGAAGCCTACAGAGCACTCCTGTCT
GGCTCAAACCCCCCCTATCTTCCATTCAGGGATGCTTCCTTTGGAAATTGCACTTACAAT
CTCACCATTCTCGACTGTTTGCAGGGAATCAGAAAGGGATTACAACATGGATTTTTTGAC
TTTGAGACATTTGATGTGGATGAATATGAACATTATGAGCGAGTTGAAAATGGTGACTTC
AACTGGATTGTTCCAGGAAAATTTTTAGCATTTAGTGGACCACATCCTAAAAGCAAAATT
GAGAATGGTTATCCTCTTCACGCCCCTGAAGCCTACTTTCCTTATTTCAAAAAGCATAAT
GTGACTGCAGTTGTGAGGCTAAACAAAAAGATTTATGAGGCAAAGCGCTTCACAGACGCT
GGCTTCGAGCACTATGACCTCTTCTTCATAGATGGCAGCACACCCAGTGACAACATCGTG
CGAAGGTTCCTGAACATCTGTGAGAACACCGAAGGGGCCATCGCCGTTCACTGCAAAGCT
GGTCTTGGAAGAACAGGGACATTGATAGCCTGTTATGTAATGAAACACTACAGGTTTACA
CATGCTGAAATAATTGCTTGGATTAGAATATGCCGGCCAGGCTCTATTATAGGACCCCAG
CAGCACTTCCTGGAAGAAAAACAAGCATCGTTGTGGGTCCAAGGAGACATTTTCCGATCC
AAACTGAAAAATCGACCATCCAGTGAAGGAAGTATTAATAAAATTCTTTCTGGCCTAGAT
GATATGTCTATTGGTGGAAATCTTTCAAAAACACAAAACATGGAACGATTTGGAGAGGAT
AACTTAGAAGATGATGATGTGGAAATGAAAAATGGTATAACCCAGGGAGACAAACTACGT
GCCTTAAAAAGTCAGAGACAGCCACGTACCTCACCATCCTGTGCATTTAGGTCAGATGAT
ACAAAAGGACATCCAAGAGCAGTGTCCCAGCCTTTCAGATTAAGTTCATCCCTGCAAGGA
TCTGCAGTTACTTTGAAGACATCAAAAATGGCACTGTCCCCTTCAGCAACGGCCAAGAGG
ATCAACAGAACTTCTTTGTCTTCGGGTGCCACTGTAAGAAGCTTTTCCATAAACTCCCGG
CTAGCCAGTTCTCTAGGGAACTTGAATGCTGCAACAGATGATCCAGAGAACAAAAAGACC
TCCTCATCCTCTAAGGCAGGCTTCACAGCCAGCCCGTTTACCAACCTCTTGAATGGCAGC
TCCCAGCCAACTACCAGAAATTACCCTGAGCTCAACAATAATCAGTACAACAGAAGCAGC
AACAGCAACGGGGGCAACCTGAACAGCCCCCCAGGCCCCCACAGCGCCAAGACAGAGGAG
CACACCACCATCCTCCGACCCTCCTACACCGGGCTTTCTTCTTCTTCAGCGAGATTCCTG
AGCCGTTCTATCCCTTCCCTTCAGTCTGAATATGTTCATTACTAA

Protein Properties

Number of Residues

594

Molecular Weight

66573.305

Theoretical pI

9.1

Pfam Domain Function

DSPc (PF00782 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Dual specificity protein phosphatase CDC14A
MAAESGELIGACEFMKDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMV
YRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLS
GSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDF
NWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDA
GFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFT
HAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLD
DMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDD
TKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSR
LASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSS
NSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPSLQSEYVHY

External Links

GenBank ID Protein

15451929

UniProtKB/Swiss-Prot ID

Q9UNH5

UniProtKB/Swiss-Prot Entry Name

CC14A_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_003672.3

GeneCard ID