| Identification |
|---|
| HMDB Protein ID
| CDBP04106 |
| Secondary Accession Numbers
| Not Available |
| Name
| Putative tyrosine-protein phosphatase auxilin |
| Description
| Not Available |
| Synonyms
|
- DnaJ homolog subfamily C member 6
|
| Gene Name
| DNAJC6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in heat shock protein binding |
| Specific Function
| Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By similarity).
|
| GO Classification
|
| Biological Process |
| cellular membrane organization |
| peptidyl-tyrosine dephosphorylation |
| post-Golgi vesicle-mediated transport |
| Cellular Component |
| cytosol |
| Function |
| binding |
| protein binding |
| heat shock protein binding |
| Molecular Function |
| protein tyrosine phosphatase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Endocytosis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p31.3 |
| SNPs
| DNAJC6 |
| Gene Sequence
|
>2742 bp
ATGAAAGATTCTGAAAATAAAGGTGCCTCATCTCCAGACATGGAGCCCAGCTATGGGGGA
GGTCTCTTTGACATGGTAAAAGGAGGTGCAGGGAGGCTCTTTAGTAACCTAAAGGACAAC
TTGAAAGACACCCTCAAAGACACATCTTCTAGAGTGATACAATCTGTGACCAGCTACACA
AAGGGAGATTTAGACTTCACTTATGTTACCTCCAGAATTATTGTGATGTCCTTTCCTCTG
GACAATGTTGACATAGGATTCAGGAATCAGGTTGATGACATTCGAAGCTTTTTGGATTCC
AGACATCTTGACCACTACACAGTATACAATCTGTCACCTAAGTCTTATCGAACTGCCAAG
TTTCACAGCCGGGTCTCAGAATGCAGTTGGCCCATTAGGCAGGCTCCCAGTCTGCACAAC
CTTTTTGCTGTGTGTCGGAATATGTATAACTGGCTACTGCAGAATCCCAAAAATGTCTGT
GTTGTCCACTGCTTGGATGGACGGGCGGCATCATCAATTCTGGTTGGTGCTATGTTCATT
TTCTGTAATCTCTACTCTACTCCTGGCCCAGCCATTCGATTGCTATATGCAAAGCGACCA
GGAATTGGACTTTCACCATCCCATAGGAGATACCTGGGCTATATGTGTGACCTACTGGCA
GACAAGCCCTACCGCCCTCACTTCAAGCCTCTCACAATTAAGTCGATCACTGTCAGTCCA
ATACCCTTTTTCAACAAACAGAGGAATGGATGTCGCCCTTACTGTGATGTACTCATTGGA
GAAACCAAAATATATTCGACTTGCACAGATTTTGAACGAATGAAAGAATATCGTGTCCAA
GATGGAAAAATCTTCATTCCCTTGAACATCACTGTGCAAGGAGACGTGGTTGTTTCCATG
TATCACTTGAGGTCAACCATTGGGAGCCGGCTACAGGCTAAGGTGACCAACACACAGATA
TTCCAGCTTCAGTTTCACACTGGATTCATACCACTGGACACAACAGTTTTAAAGTTCACC
AAGCCTGAGTTAGATGCATGTGATGTACCAGAAAAATATCCTCAGCTATTTCAGGTGACA
CTGGATGTAGAACTACAGCCCCATGACAAAGTAATAGACTTAACTCCACCATGGGAACAT
TACTGCACAAAAGATGTCAATCCCAGCATCCTCTTCTCTTCTCACCAGGAACATCAAGAT
ACGCTGGCCTTAGGAGGACAGGCTCCAATAGATATCCCTCCAGACAACCCCAGGCATTAC
GGACAAAGTGGTTTCTTTGCCTCTCTCTGTTGGCAAGATCAGAAATCGGAGAAGTCATTC
TGTGAGGAGGACCACGCTGCCCTAGTGAATCAGGAAAGTGAGCAATCAGATGATGAACTT
CTGACACTTTCCAGTCCGCATGGCAATGCCAATGGTGACAAGCCTCATGGAGTCAAGAAG
CCCAGCAAAAAGCAGCAGGAGCCAGCAGCCCCTCCACCCCCTGAGGATGTGGACCTTTTG
GGCCTGGAAGGGTCTGCAATGAGTAACAGCTTCTCTCCGCCAGCGGCTCCTCCCACCAAT
TCTGAACTACTGAGTGACCTGTTTGGGGGTGGAGGTGCAGCTGGTCCCACCCAGGCTGGA
CAGTCAGGAGTGGAAGATGTGTTTCATCCTAGTGGACCTGCGTCTACCCAGTCAACACCA
CGCCGCTCTGCCACCTCCACCTCTGCGTCTCCAACCCTAAGAGTGGGAGAAGGTGCCACC
TTTGACCCATTTGGAGCACCTTCTAAACCATCAGGTCAGGATTTGCTGGGTTCTTTTCTG
AACACATCCAGTGCTTCCAGTGACCCCTTTCTCCAGCCAACAAGAAGTCCTTCGCCCACA
GTACATGCTTCTAGTACGCCTGCTGTGAACATTCAGCCAGATGTTTCTGGAGGTTGGGAC
TGGCATGCTAAACCAGGAGGCTTTGGAATGGGAAGCAAGTCAGCTGCCACCAGCCCAACC
GGATCCTCGCATGGTACTCCCACCCATCAAAGCAAACCCCAGACTCTGGATCCTTTTGCC
GACCTTGGGACACTAGGTAGTTCTTCCTTTGCCAGCAAACCCACCACACCAACTGGATTG
GGTGGAGGATTCCCGCCTCTCAGCTCGCCACAGAAGGCGTCTCCCCAGCCTATGGGTGGC
GGGTGGCAGCAGGGAGGTGCCTACAACTGGCAGCAGCCACAGCCTAAGCCTCAGCCCAGC
ATGCCCCACTCCTCTCCCCAGAACCGACCCAACTACAACGTGAGCTTCTCAGCCATGCCT
GGGGGCCAGAACGAACGTGGGAAAGGATCAAGTAATTTGGAAGGGAAACAAAAAGCAGCT
GATTTTGAAGACCTACTCTCTGGTCAAGGTTTCAATGCTCACAAAGACAAAAAGGGGCCT
CGGACAATAGCTGAGATGAGAAAGGAGGAAATGGCCAAGGAAATGGATCCTGAGAAATTA
AAGATTCTGGAATGGATTGAAGGCAAAGAAAGAAATATCAGAGCCCTTCTTTCCACGATG
CATACCGTACTATGGGCTGGGGAGACCAAGTGGAAACCAGTTGGCATGGCAGACCTGGTA
ACACCAGAGCAGGTGAAGAAGGTGTACAGGAAGGCTGTCCTGGTGGTGCACCCAGATAAA
GCTACTGGGCAACCCTATGAACAATACGCAAAGATGATTTTCATGGAGCTCAATGATGCC
TGGTCTGAATTTGAAAACCAAGGCCAAAAGCCCTTATATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 913 |
| Molecular Weight
| 105673.905 |
| Theoretical pI
| 7.471 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Putative tyrosine-protein phosphatase auxilin
MKDSENKGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQSVTSYT
KGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAK
FHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFI
FCNLYSTPGPAIRLLYAKRPGIGLSPSHRRYLGYMCDLLADKPYRPHFKPLTIKSITVSP
IPFFNKQRNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVVVSM
YHLRSTIGSRLQAKVTNTQIFQLQFHTGFIPLDTTVLKFTKPELDACDVPEKYPQLFQVT
LDVELQPHDKVIDLTPPWEHYCTKDVNPSILFSSHQEHQDTLALGGQAPIDIPPDNPRHY
GQSGFFASLCWQDQKSEKSFCEEDHAALVNQESEQSDDELLTLSSPHGNANGDKPHGVKK
PSKKQQEPAAPPPPEDVDLLGLEGSAMSNSFSPPAAPPTNSELLSDLFGGGGAAGPTQAG
QSGVEDVFHPSGPASTQSTPRRSATSTSASPTLRVGEGATFDPFGAPSKPSGQDLLGSFL
NTSSASSDPFLQPTRSPSPTVHASSTPAVNIQPDVSGGWDWHAKPGGFGMGSKSAATSPT
GSSHGTPTHQSKPQTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGG
GWQQGGAYNWQQPQPKPQPSMPHSSPQNRPNYNVSFSAMPGGQNERGKGSSNLEGKQKAA
DFEDLLSGQGFNAHKDKKGPRTIAEMRKEEMAKEMDPEKLKILEWIEGKERNIRALLSTM
HTVLWAGETKWKPVGMADLVTPEQVKKVYRKAVLVVHPDKATGQPYEQYAKMIFMELNDA
WSEFENQGQKPLY
|
| External Links |
|---|
| GenBank ID Protein
| 7662146 |
| UniProtKB/Swiss-Prot ID
| O75061 |
| UniProtKB/Swiss-Prot Entry Name
| AUXI_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014787.2 |
| GeneCard ID
| DNAJC6 |
| GenAtlas ID
| DNAJC6 |
| HGNC ID
| HGNC:15469 |
| References |
|---|
| General References
| Not Available |