| Identification |
|---|
| HMDB Protein ID
| CDBP04102 |
| Secondary Accession Numbers
| Not Available |
| Name
| Oxidoreductase HTATIP2 |
| Description
| Not Available |
| Synonyms
|
- 30 kDa HIV-1 TAT-interacting protein
- HIV-1 TAT-interactive protein 2
|
| Gene Name
| HTATIP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect |
| GO Classification
|
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| binding |
| nucleotide binding |
| catalytic activity |
| nad or nadh binding |
| oxidoreductase activity |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, nad or nadp as acceptor |
| Process |
| metabolic process |
| cellular metabolic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
- Cytoplasm
- Nucleus envelope
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p15.1 |
| SNPs
| HTATIP2 |
| Gene Sequence
|
>729 bp
ATGGCCGAAACAGAAGCCCTGTCGAAGCTTCGGGAAGACTTCAGGATGCAGAATAAATCC
GTCTTTATTTTGGGCGCCAGCGGAGAAACCGGCAGAGTGCTCTTAAAGGAAATCCTGGAG
CAGGGCCTGTTTTCCAAAGTCACGCTCATTGGCCGGAGGAAGCTCACCTTCGACGAGGAA
GCTTATAAAAATGTGAATCAAGAAGTGGTGGACTTTGAAAAGTTGGATGACTACGCCTCT
GCCTTTCAAGGTCATGATGTTGGATTCTGTTGCCTGGGTACCACCAGAGGGAAAGCTGGG
GCGGAGGGATTTGTTCGTGTTGACCGAGATTATGTGCTGAAGTCTGCAGAGCTGGCAAAA
GCTGGAGGGTGCAAACATTTCAACTTGCTATCCTCTAAAGGAGCTGATAAATCAAGCAAT
TTTTTATATCTACAAGTTAAGGGAGAAGTAGAAGCCAAGGTTGAAGAATTAAAATTTGAT
CGTTACTCTGTATTTAGGCCTGGAGTTCTGTTATGTGATAGGCAAGAATCTCGCCCAGGT
GAATGGCTGGTTAGAAAGTTCTTTGGCTCCTTACCAGACTCTTGGGCCAGTGGGCATTCT
GTGCCTGTGGTGACCGTGGTTAGAGCAATGCTGAACAATGTGGTGAGACCAAGAGACAAG
CAGATGGAACTGCTGGAGAACAAGGCCATCCATGACCTGGGGAAAGCGCATGGCTCTCTC
AAGCCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 242 |
| Molecular Weight
| 27117.9 |
| Theoretical pI
| 8.88 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Oxidoreductase HTATIP2
MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEE
AYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAK
AGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPG
EWLVRKFFGSLPDSWARGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSL
KP
|
| External Links |
|---|
| GenBank ID Protein
| 148728168 |
| UniProtKB/Swiss-Prot ID
| Q9BUP3 |
| UniProtKB/Swiss-Prot Entry Name
| HTAI2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001098521.1 |
| GeneCard ID
| HTATIP2 |
| GenAtlas ID
| HTATIP2 |
| HGNC ID
| HGNC:16637 |
| References |
|---|
| General References
| Not Available |