| Identification |
|---|
| HMDB Protein ID
| CDBP04096 |
| Secondary Accession Numbers
| Not Available |
| Name
| Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Protein SITPEC
|
| Gene Name
| ECSIT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity, acting on NADH or |
| Specific Function
| Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development. Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Mitochondrion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.2 |
| SNPs
| ECSIT |
| Gene Sequence
|
>1296 bp
ATGAGCTGGGTCCAGGCCACCCTACTGGCCCGAGGCCTCTGTAGGGCCTGGGGAGGCACC
TGCGGGGCCGCCCTCACAGGAACCTCCATCTCTCAGGTCCCTCGCCGGCTCCCTCGGGGC
CTCCACTGCAGCGCAGCTGCCCATAGCTCTGAACAGTCCCTGGTTCCCAGCCCACCGGAA
CCCCGGCAGAGGCCCACCAAGGCTCTGGTGCCCTTTGAGGACCTGTTTGGGCAGGCGCCT
GGTGGGGAACGGGACAAGGCGAGCTTCCTGCAGACGGTGCAGAAATTTGCGGAGCACAGC
GTGCGTAAGCGGGGCCACATTGACTTCATCTACCTGGCCCTGCGCAAGATGCGGGAGTAT
GGTGTCGAGCGGGACCTGGCTGTGTACAACCAGCTGCTCAACATCTTCCCCAAGGAGGTC
TTCCGGCCTCGCAACATCATCCAGCGCATCTTCGTCCACTACCCTCGGCAGCAGGAGTGT
GGGATTGCTGTCCTGGAGCAGATGGAGAACCACGGTGTGATGCCCAACAAGGAGACGGAG
TTCCTGCTGATTCAGATCTTTGGACGCAAAAGCTACCCCATGCTCAAGTTGGTGCGCCTG
AAGCTGTGGTTCCCTCGATTCATGAACGTCAACCCCTTCCCAGTGCCCCGGGACCTGCCC
CAGGACCCTGTGGAGCTGGCCATGTTTGGCCTGCGGCACATGGAGCCTGACCTTAGTGCC
AGGGTCACCATCTACCAGGTTCCTTTGCCCAAAGACTCAACAGGTGCAGCAGATCCCCCC
CAGCCCCACATCGTAGGAATCCAGAGTCCCGATCAGCAGGCCGCCCTGGCCTGCCACAAT
CCAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTGGCTCCGCAACAAGTGTGTG
TATTACCACATCCTCAGAGCTGACTTGCTGCCCCCGGAGGAGAGGGAAGTGGAAGAGACG
CCGGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGC
TGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGC
ATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACC
AACCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGGTCCACCCGGGAGCTC
CAGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGAC
GACAACCTGCAGCGACAGCAGCAGGGCCAGAGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 431 |
| Molecular Weight
| 49147.8 |
| Theoretical pI
| 6.25 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPE
PRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREY
GVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETE
FLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSA
RVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCV
YYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMC
MAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEED
DNLQRQQQGQS
|
| External Links |
|---|
| GenBank ID Protein
| 7407498 |
| UniProtKB/Swiss-Prot ID
| Q9BQ95 |
| UniProtKB/Swiss-Prot Entry Name
| ECSIT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF243044 |
| GeneCard ID
| ECSIT |
| GenAtlas ID
| ECSIT |
| HGNC ID
| HGNC:29548 |
| References |
|---|
| General References
| Not Available |