| Identification |
|---|
| HMDB Protein ID
| CDBP04085 |
| Secondary Accession Numbers
| Not Available |
| Name
| TCDD-inducible poly [ADP-ribose] polymerase |
| Description
| Not Available |
| Synonyms
|
- PARP-7
- Poly [ADP-ribose] polymerase 7
- ADP-ribosyltransferase diphtheria toxin-like 14
- ARTD14
|
| Gene Name
| TIPARP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NAD+ ADP-ribosyltransferase activity |
| Specific Function
| Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).
|
| GO Classification
|
| Biological Process |
| skeletal system morphogenesis |
| nitrogen compound metabolic process |
| female gonad development |
| multicellular organismal metabolic process |
| platelet-derived growth factor receptor signaling pathway |
| smooth muscle tissue development |
| vasculogenesis |
| androgen metabolic process |
| kidney development |
| post-embryonic development |
| estrogen metabolic process |
| face morphogenesis |
| palate development |
| protein ADP-ribosylation |
| hemopoiesis |
| Function |
| zinc ion binding |
| transferase activity |
| nad+ adp-ribosyltransferase activity |
| transferase activity, transferring pentosyl groups |
| nucleic acid binding |
| transferase activity, transferring glycosyl groups |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| Molecular Function |
| nucleic acid binding |
| metal ion binding |
| NAD+ ADP-ribosyltransferase activity |
| zinc ion binding |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q25.31 |
| SNPs
| TIPARP |
| Gene Sequence
|
>1974 bp
ATGGAAATGGAAACCACCGAACCTGAGCCAGACTGTGTAGTGCAGCCTCCCTCTCCTCCT
GATGACTTTTCATGCCAAATGAGACTCTCTGAGAAGATCACTCCATTGAAGACTTGTTTT
AAGAAAAAGGATCAGAAAAGATTGGGAACTGGAACCCTGAGGTCTTTGAGGCCAATATTA
AACACTCTTCTAGAATCTGGCTCACTTGATGGGGTTTTTAGATCTAGGAACCAGAGTACA
GATGAGAACAGCTTACATGAACCTATGATGAAGAAAGCCATGGAAATCAATTCATCATGC
CCACCAGCAGAAAATAATATGTCTGTTCTGATTCCTGATAGGACAAATGTTGGGGACCAG
ATACCGGAAGCCCATCCTTCCACTGAAGCTCCAGAACGAGTGGTTCCAATCCAAGATCAC
AGCTTTCCATCAGAAACCCTCAGTGGGACGGTGGCAGATTCCACACCAGCTCACTTCCAG
ACTGATCTTTTGCACCCAGTTTCAAGTGATGTTCCTACTAGTCCTGACTGCTTAGACAAA
GTCATAGATTATGTTCCAGGCATTTTCCAAGAAAACAGTTTTACAATCCAATACATTCTG
GACACCAGTGATAAGCTGAGTACTGAGCTCTTTCAGGACAAAAGTGAAGAGGCTTCCCTT
GACCTCGTGTTTGAGCTGGTGAACCAGTTGCAGTACCACACTCACCAAGAGAACGGAATT
GAAATTTGCATGGACTTTCTGCAAGGCACTTGTATTTATGGCAGGGATTGTTTGAAGCAC
CACACTGTCTTGCCATATCATTGGCAGATCAAAAGGACAACTACTCAAAAGTGGCAGAGT
GTATTCAATGATTCTCAGGAGCACTTGGAAAGATTTTACTGTAACCCAGAAAATGATAGA
ATGAGAATGAAGTATGGAGGACAAGAATTTTGGGCAGATTTGAATGCCATGAACGTGTAT
GAAACAACTGAATTTGACCAACTACGAAGGCTGTCCACACCACCCTCTAGCAATGTCAAC
TCTATTTACCACACAGTCTGGAAATTCTTCTGTAGGGACCACTTTGGATGGAGAGAGTAT
CCCGAGTCTGTCATTCGATTGATTGAAGAAGCCAACTCTCGGGGTCTGAAAGAGGTTCGA
TTTATGATGTGGAATAACCACTACATCCTCCACAATTCATTCTTCAGGAGAGAGATAAAA
AGGAGACCCCTCTTCCGCTCCTGTTTTATACTGCTTCCATATTTACAGACACTTGGTGGG
GTTCCCACACAAGCTCCTCCACCTCTTGAAGCAACTTCATCATCACAAATTATCTGCCCA
GATGGGGTCACTTCAGCAAACTTTTACCCTGAAACTTGGGTTTATATGCATCCATCTCAG
GACTTCATCCAAGTCCCTGTTTCTGCAGAGGATAAAAGTTATCGGATCATTTACAATCTT
TTTCATAAGACTGTGCCTGAGTTTAAATACAGAATTTTGCAGATATTGAGAGTCCAAAAC
CAGTTTCTTTGGGAGAAATATAAAAGGAAAAAGGAATATATGAACAGGAAAATGTTTGGC
CGTGACAGGATAATAAATGAGAGACATTTATTTCATGGAACATCCCAGGATGTGGTAGAT
GGAATCTGCAAACACAACTTTGACCCTCGAGTCTGTGGAAAGCATGCTACAATGTTTGGA
CAAGGCAGTTATTTTGCAAAGAAGGCAAGCTACTCTCATAACTTTTCTAAGAAGTCCTCC
AAAGGAGTCCACTTCATGTTTCTGGCCAAAGTGCTGACGGGCAGATACACAATGGGCAGT
CATGGCATGAGAAGGCCCCCGCCAGTCAATCCTGGCAGTGTCACCAGTGACCTTTATGAC
TCTTGTGTGGATAATTTCTTTGAGCCTCAGATTTTTGTCATTTTTAATGATGACCAGAGT
TACCCTTATTTTGTTATCCAATATGAAGAAGTCAGTAACACTGTTTCCATTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 657 |
| Molecular Weight
| 76226.74 |
| Theoretical pI
| 6.658 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>TCDD-inducible poly [ADP-ribose] polymerase
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL
NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ
IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK
VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI
EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR
MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY
PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG
VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL
FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD
GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS
HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
|
| External Links |
|---|
| GenBank ID Protein
| 296080688 |
| UniProtKB/Swiss-Prot ID
| Q7Z3E1 |
| UniProtKB/Swiss-Prot Entry Name
| PARPT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001184717.1 |
| GeneCard ID
| TIPARP |
| GenAtlas ID
| TIPARP |
| HGNC ID
| HGNC:23696 |
| References |
|---|
| General References
| Not Available |