| Identification |
|---|
| HMDB Protein ID
| CDBP04079 |
| Secondary Accession Numbers
| Not Available |
| Name
| Poly [ADP-ribose] polymerase 14 |
| Description
| Not Available |
| Synonyms
|
- B aggressive lymphoma protein 2
- PARP-14
- ADP-ribosyltransferase diphtheria toxin-like 8
- ARTD8
|
| Gene Name
| PARP14 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NAD+ ADP-ribosyltransferase activity |
| Specific Function
| Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
|
| GO Classification
|
| Biological Process |
| regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| Cellular Component |
| cytoplasm |
| plasma membrane |
| nucleus |
| Function |
| catalytic activity |
| transferase activity |
| nad+ adp-ribosyltransferase activity |
| transferase activity, transferring pentosyl groups |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| NAD+ ADP-ribosyltransferase activity |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q21.1 |
| SNPs
| PARP14 |
| Gene Sequence
|
>5406 bp
ATGGCTGTGCCCGGCTCCTTCCCGCTGCTGGTCGAGGGCTCCTGGGGCCCCGACCCCCCG
AAGAACTTGAACACCAAGTTGCAGATGTACTTCCAGAGCCCGAAGAGGTCGGGAGGCGGC
GAGTGTGAGGTCCGCCAGGATCCCAGGAGCCCATCCCGCTTCCTGGTGTTCTTCTACCCG
GAGGACGTTCGGCAGAAGGTTCTGGAGAGAAAAAATCATGAGTTGGTATGGCAAGGAAAA
GGAACATTCAAGTTAACTGTCCAGTTACCTGCAACCCCAGATGAAATCGATCATGTCTTT
GAAGAGGAACTTCTAACAAAAGAATCCAAGACCAAAGAAGATGTTAAAGAACCAGATGTG
TCAGAAGAATTGGATACAAAACTCCCTCTTGATGGTGGATTAGACAAAATGGAAGATATC
CCAGAGGAATGTGAAAATATTTCCTCTTTGGTGGCATTTGAAAACCTCAAGGCAAATGTG
ACTGACATAATGCTAATCTTGTTAGTGGAGAACATAAGTGGCCTGTCTAATGATGACTTT
CAAGTGGAAATAATAAGAGATTTTGATGTTGCTGTTGTTACCTTTCAAAAGCACATAGAT
ACTATAAGATTTGTTGATGATTGTACCAAGCACCATTCAATTAAACAACTTCAGCTTTCT
CCAAGACTTCTGGAAGTGACAAACACAATCAGGGTTGAAAACCTGCCACCTGGTGCTGAT
GACTACAGTTTAAAACTTTTCTTTGAAAATCCCTATAATGGAGGGGGAAGAGTTGCCAAT
GTTGAATATTTTCCTGAAGAGAGTTCAGCTCTGATTGAATTTTTTGACAGAAAAGTGTTA
GACACCATCATGGCCACAAAACTCGACTTCAATAAAATGCCACTTTCTGTGTTCCCATAC
TATGCCTCATTGGGCACAGCCTTGTATGGAAAGGAGAAGCCTCTGATCAAGCTTCCAGCA
CCATTTGAAGAGTCACTAGATCTTCCCTTATGGAAGTTCTTACAGAAAAAGAATCACCTC
ATTGAGGAGATAAACGATGAAATGAGGCGTTGTCACTGTGAGCTCACGTGGTCCCAACTC
AGTGGTAAAGTTACCATCAGACCAGCAGCCACCTTAGTCAATGAAGGAAGACCGAGAATC
AAGACCTGGCAGGCAGATACTTCCACAACACTCTCTAGCATCAGGTCTAAATATAAAGTC
AACCCAATTAAAGTGGATCCAACAATGTGGGACACCATAAAAAATGATGTGAAAGATGAC
AGGATTTTGATTGAGTTTGATACACTTAAGGAGATGGTAATCTTAGCAGGGAAATCAGAG
GATGTCCAAAGCATTGAGGTACAAGTCAGGGAGTTAATAGAAAGCACTACTCAAAAAATT
AAAAGGGAAGAGCAAAGTTTGAAGGAAAAAATGATCATTTCTCCAGGCAGGTATTTTCTT
TTGTGTCACAGCAGTCTACTGGACCATTTACTCACGGAGTGCCCAGAGATAGAGATTTGT
TACGATAGAGTCACTCAACACTTGTGCTTGAAAGGACCTAGTGCAGATGTGTATAAAGCA
AAGTGTGAAATCCAGGAAAAGGTGTACACCATGGCTCAGAAAAACATTCAGGTTTCTCCT
GAGATTTTTCAGTTTTTGCAACAGGTAAACTGGAAAGAATTCTCTAAGTGTCTTTTCATA
GCACAGAAGATTCTTGCACTTTATGAGCTAGAGGGTACAACTGTTCTCTTAACCAGCTGT
TCTTCTGAAGCCCTGTTAGAAGCAGAAAAGCAAATGCTCAGTGCCTTAAATTATAAGCGC
ATTGAAGTTGAGAACAAAGAAGTTCTTCATGGCAAGAAATGGAAAGGGCTCACTCACAAT
TTGCTTAAGAAACAAAATTCCTCCCCAAACACTGTAATCATCAATGAGTTAACTTCAGAA
ACCACAGCTGAAGTCATCATTACAGGCTGTGTAAAAGAAGTAAATGAAACCTATAAATTG
CTTTTTAACTTCGTTGAACAAAACATGAAAATAGAGAGACTGGTTGAAGTAAAGCCTTCC
TTAGTTATTGACTATTTAAAGACAGAAAAGAAGCTATTCTGGCCAAAGATAAAGAAGGTA
AATGTGCAGGTAAGTTTCAATCCTGAGAACAAACAAAAAGGCATTTTACTAACTGGCTCA
AAGACCGAAGTACTGAAGGCAGTGGACATTGTCAAGCAAGTCTGGGATTCAGTCTGTGTT
AAAAGTGTCCATACTGATAAGCCAGGAGCCAAGCAGTTCTTCCAGGATAAAGCACGGTTT
TATCAAAGTGAGATCAAACGGTTGTTTGGTTGTTACATTGAACTACAGGAGAATGAAGTA
ATGAAGGAGGGAGGCAGCCCCGCTGGGCAGAAGTGCTTCTCTCGGACAGTCTTGGCCCCT
GGCGTTGTGCTGATTGTGCAGCAGGGTGACTTGGCACGGCTTCCTGTCGATGTGGTGGTG
AATGCATCTAATGAGGACCTTAAGCATTATGGTGGCCTGGCCGCTGCGCTCTCAAAAGCA
GCTGGCCCTGAGCTCCAGGCCGACTGTGACCAGATAGTGAAGAGAGAGGGCAGACTCCTA
CCGGGCAATGCCACCATCTCCAAGGCAGGAAAGCTGCCCTACCACCACGTGATCCATGCA
GTGGGGCCCCGCTGGAGCGGATATGAGGCCCCGAGGTGTGTGTACCTATTAAGGAGAGCT
GTGCAACTCAGTCTCTGTCTAGCCGAAAAATACAAGTACCGATCCATAGCCATCCCAGCT
ATTAGTTCTGGAGTCTTTGGCTTTCCCTTAGGCCGATGCGTGGAGACCATTGTTTCTGCC
ATCAAGGAAAACTTCCAATTCAAGAAGGATGGACACTGCTTGAAAGAAATCTACCTTGTG
GATGTATCTGAGAAGACTGTTGAGGCCTTTGCAGAAGCTGTGAAAACTGTATTTAAAGCC
ACCCTGCCAGATACAGCTGCCCCGCCAGGTTTACCACCAGCAGCAGCGGGGCCTGGGAAA
ACATCATGGGAAAAAGGAAGCCTGGTGTCCCCGGGAGGCCTGCAGATGCTGTTGGTGAAA
GAGGGTGTGCAGAATGCTAAGACCGATGTTGTTGTCAACTCCGTTCCCTTGGATCTCGTG
CTTAGTAGAGGGCCTCTTTCTAAGTCCCTCTTGGAAAAAGCTGGACCAGAGCTCCAGGAG
GAATTGGACACAGTTGGACAAGGGGTGGCTGTCAGCATGGGCACAGTGCTCAAAACCAGC
AGCTGGAATCTGGACTGTCGCTATGTGCTTCACGTGGTAGCTCCGGAGTGGAGAAATGGT
AGCACATCTTCACTCAAGATAATGGAAGACATAATCAGAGAATGTATGGAGATCACTGAG
AGCTTGTCCTTAAAATCAATTGCATTTCCAGCAATAGGAACAGGAAACTTGGGATTTCCT
AAAAACATATTCGCTGAATTAATCATTTCAGAGGTGTTCAAATTTAGTAGCAAGAATCAG
CTGAAAACTTTACAAGAGGTTCACTTTCTGCTGCACCCGAGTGATCATGAAAATATTCAG
GCATTTTCAGATGAATTTGCCAGAAGGGCTAATGGAAATCTCGTCAGTGACAAAATTCCG
AAGGCTAAAGATACACAAGGTTTTTATGGGACTGTTTCTAGCCCTGATTCAGGTGTGTAT
GAAATGAAGATTGGCTCCATCATCTTCCAGGTGGCTTCTGGAGATATCACGAAAGAAGAG
GCAGATGTGATTGTAAATTCAACATCAAACTCATTCAATCTCAAAGCAGGGGTCTCCAAA
GCAATTTTAGAATGTGCTGGACAAAATGTAGAAAGGGAATGTTCTCAGCAAGCTCAGCAG
CGCAAAAATGATTATATAATCACCGGAGGTGGATTTTTGAGGTGCAAGAATATCATTCAT
GTAATTGGTGGAAATGATGTCAAGAGTTCAGTTTCCTCTGTTTTGCAGGAGTGTGAAAAA
AAAAATTACTCATCCATTTGCCTCCCAGCCATTGGGACAGGAAATGCCAAACAACACCCA
GATAAGGTTGCTGAAGCCATAATTGATGCCATTGAAGACTTTGTCCAGAAAGGATCAGCC
CAGTCTGTGAAAAAAGTTAAAGTTGTTATCTTTCTGCCTCAAGTACTGGATGTGTTTTAT
GCCAACATGAAGAAAAGAGAAGGGACTCAGCTTTCTTCCCAACAGTCTGTGATGTCTAAA
CTTGCATCATTTTTGGGCTTTTCAAAGCAATCTCCCCAAAAAAAGAATCATTTGGTTTTG
GAAAAGAAAACAGAATCAGCAACTTTTCGGGTGTGTGGTGAAAATGTCACGTGTGTGGAA
TATGCTATCTCCTGGCTACAAGACCTGATTGAAAAAGAACAGTGTCCTTACACCAGTGAA
GATGAGTGCATCAAAGACTTTGATGAAAAGGAGTATCAGGAGTTGAATGAGCTGCAGAAG
AAGTTAAATATTAACATTTCCCTGGACCATAAGAGACCTTTGATTAAGGTTTTGGGAATT
AGCAGAGATGTGATGCAGGCTAGAGATGAAATTGAGGCGATGATCAAGAGAGTTCGATTG
GCCAAAGAACAGGAATCCCGGGCAGATTGTATCAGTGAGTTTATAGAATGGCAGTATAAT
GACAATAACACTTCTCATTGTTTTAACAAAATGACCAATCTGAAATTAGAGGATGCAAGG
AGAGAAAAGAAAAAAACAGTTGATGTCAAAATTAATCATCGGCACTACACAGTGAACTTG
AACACATACACTGCCACAGACACAAAGGGCCACAGTTTATCTGTTCAGCGCCTCACGAAA
TCCAAAGTTGACATCCCTGCACACTGGAGTGATATGAAGCAGCAGAATTTCTGTGTGGTG
GAGCTGCTGCCTAGTGATCCTGAGTACAACACGGTGGCAAGCAAGTTTAATCAGACCTGC
TCACACTTCAGAATAGAGAAGATTGAGAGGATCCAGAATCCAGATCTCTGGAATAGCTAC
CAGGCAAAGAAAAAAACTATGGATGCCAAGAATGGCCAGACAATGAATGAGAAGCAACTC
TTCCATGGGACAGATGCCGGCTCCGTGCCACACGTCAATCGAAATGGCTTTAACCGCAGC
TATGCCGGAAAGAATGCTGTGGCATATGGAAAGGGAACCTATTTTGCTGTCAATGCCAAT
TATTCTGCCAATGATACGTACTCCAGACCAGATGCAAATGGGAGAAAGCATGTGTATTAT
GTGCGAGTACTTACTGGAATCTATACACATGGAAATCATTCATTAATTGTGCCTCCTTCA
AAGAACCCTCAAAATCCTACTGACCTGTATGACACTGTCACAGATAATGTGCACCATCCA
AGTTTATTTGTGGCATTTTATGACTACCAAGCATACCCAGAGTACCTTATTACGTTTAGA
AAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 1720 |
| Molecular Weight
| 202798.68 |
| Theoretical pI
| 7.181 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Poly [ADP-ribose] polymerase 14
MAVPGSFPLLVEGSWGPDPPKNLNTKLQMYFQSPKRSGGGECEVRQDPRSPSRFLVFFYP
EDVRQKVLERKNHELVWQGKGTFKLTVQLPATPDEIDHVFEEELLTKESKTKEDVKEPDT
IRFVDDCTKHHSIKQLQLSPRLLEVTNTIRVENLPPGADDYSLKLFFENPYNGGGRVANV
EYFPEESSALIEFFDRKVLDTIMATKLDFNKMPLSVFPYYASLGTALYGKEKPLIKLPAP
FEESLDLPLWKFLQKKNHLIEEINDEMRRCHCELTWSQLSGKVTIRPAATLVNEGRPRIK
TWQADTSTTLSSIRSKYKVNPIKVDPTMWDTIKNDVKDDRILIEFDTLKEMVILAGKSED
VQSIEVQVRELIESTTQKIKREEQSLKEKMIISPGRYFLLCHSSLLDHLLTECPEIEICY
DRVTQHLCLKGPSADVYKAKCEIQEKVYTMAQKNIQVSPEIFQFLQQVNWKEFSKCLFIA
QKILALYELEGTTVLLTSCSSEALLEAEKQMLSALNYKRIEVENKEVLHGKKWKGLTHNL
LKKQNSSPNTVIINELTSETTAEVIITGCVKEVNETYKLLFNFVEQNMKIERLVEVKPSL
VIDYLKTEKKLFWPKIKKVNVQVSFNPENKQKGILLTGSKTEVLKAVDIVKQVWDSVCVK
SVHTDKPGAKQFFQDKARFYQSEIKRLFGCYIELQENEVMKEGGSPAGQKCFSRTVLAPG
VVLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLP
GNATISKAGKLPYHHVIHAVGPRWSGYEAPRCVYLLRRAVQLSLCLAEKYKYRSIAIPAI
SSGVFGFPLGRCVETIVSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKAT
LPDTAAPPGLPPAAAGPGKTSWEKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVL
SRGPLSKSLLEKAGPELQEELDTVGQGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGS
TSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKNQL
KTLQEVHFLLHPSDHENIQAFSDEFARRANGNLVSDKIPKAKDTQGFYGTVSSPDSGVYE
MKIGSIIFQVASGDITKEEADVIVNSTSNSFNLKAGVSKAILECAGQNVERECSQQAQQR
KNDYIITGGGFLRCKNIIHVIGGNDVKSSVSSVLQECEKKNYSSICLPAIGTGNAKQHPD
KVAEAIIDAIEDFVQKGSAQSVKKVKVVIFLPQVLDVFYANMKKREGTQLSSQQSVMSKL
ASFLGFSKQSPQKKNHLVLEKKTESATFRVCGENVTCVEYAISWLQDLIEKEQCPYTSED
ECIKDFDEKEYQELNELQKKLNINISLDHKRPLIKVLGISRDVMQARDEIEAMIKRVRLA
KEQESRADCISEFIEWQYNDNNTSHCFNKMTNLKLEDARREKKKTVDVKINHRHYTVNLN
TYTATDTKGHSLSVQRLTKSKVDIPAHWSDMKQQNFCVVELLPSDPEYNTVASKFNQTCS
HFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSY
AGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSK
NPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
|
| External Links |
|---|
| GenBank ID Protein
| 154813199 |
| UniProtKB/Swiss-Prot ID
| Q460N5 |
| UniProtKB/Swiss-Prot Entry Name
| PAR14_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| PARP14 |
| GenAtlas ID
| PARP14 |
| HGNC ID
| HGNC:29232 |
| References |
|---|
| General References
| Not Available |