| Identification |
|---|
| HMDB Protein ID
| CDBP04076 |
| Secondary Accession Numbers
| Not Available |
| Name
| Poly [ADP-ribose] polymerase 10 |
| Description
| Not Available |
| Synonyms
|
- PARP-10
- ADP-ribosyltransferase diphtheria toxin-like 10
- ARTD10
|
| Gene Name
| PARP10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.
|
| GO Classification
|
| Biological Process |
| negative regulation of fibroblast proliferation |
| protein poly-ADP-ribosylation |
| regulation of chromatin assembly |
| Cellular Component |
| Golgi apparatus |
| nucleus |
| Function |
| catalytic activity |
| transferase activity |
| nad+ adp-ribosyltransferase activity |
| transferase activity, transferring pentosyl groups |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| NAD+ ADP-ribosyltransferase activity |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- nucleolus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8q24.3 |
| SNPs
| PARP10 |
| Gene Sequence
|
>3078 bp
ATGGTTGCAATGGCGGAGGCAGAGGCAGGGGTGGCAGTGGAGGTCCGTGGACTGCCCCCT
GCCGTGCCCGACGAGCTGCTCACTCTCTACTTTGAAAACCGCCGACGCTCTGGAGGGGGA
CCTGTGTTGAGCTGGCAGAGACTGGGCTGTGGGGGCGTCCTCACCTTCAGAGAGCCTGCA
GACGCCGAGAGGGTCTTGGCCCAGGCAGATCACGAACTACATGGTGCCCAGCTGAGCCTG
CGGCCAGCTCCACCACGAGCCCCTGCACGCCTGCTGCTCCAAGGACTGCCCCCTGGCACC
ACGCCCCAGCGCTTGGAGCAGCATGTCCAGGCCTTGCTGCGGGCCTCGGGGCTCCCAGTA
CAGCCTTGCTGTGCCTTGGCCAGCCCCCGGCCAGACCGGGCTCTGGTCCAGTTGCCCAAG
CCCCTTTCTGAGGCAGATGTCCGTGTCCTGGAGGAGCAGGCCCAGAATCTGGGCCTGGAG
GGGACCTTGGTGTCCCTGGCCCGGGTTCCCCAGGCCCGAGCGGTGCGTGTGGTGGGGGAT
GGTGCCTCTGTGGACCTGCTGTTGCTGGAGTTGTACCTGGAGAATGAGCGCCGCAGTGGT
GGGGGGCCCCTGGAGGACCTGCAACGCCTACCCGGGCCCCTGGGCACTGTTGCCTCCTTC
CAGCAGTGGCAAGTGGCAGAACGAGTGTTGCAGCAGGAGCACCGGTTGCAGGGCTCAGAG
CTGAGCCTTGTCCCCCACTACGACATCCTGGAGCCCGAGGAGCTGGCTGAGAACACCAGT
GGAGGGGACCACCCGTCCACCCAGGGGCCTAGGGCTACCAAGCATGCTCTCCTGAGGACC
GGAGGGTTGGTGACGGCTCTGCAGGGTGCAGGGACTGTGACAATGGGCTCTGGCGAGGAA
CCAGGGCAGTCAGGGGCCTCTCTGAGGACAGGTCCCATGGTGCAGGGTAGAGGGATTATG
ACAACAGGCTCTGGCCAGGAACCAGGGCAGTCAGGGACCTCTCTGAGGACAGGTCCCATG
GGGTCTCTGGGACAGGCAGAGCAAGTCAGCTCGATGCCCATGGGGTCTCTGGAACATGAG
GGGCTGGTAAGCCTGAGGCCTGTGGGGTTGCAGGAACAGGAGGGGCCCATGAGCCTGGGG
CCTGTGGGGTCTGCAGGCCCAGTGGAGACCTCTAAGGGGTTGCTGGGGCAGGAGGGCCTG
GTGGAAATTGCCATGGACTCACCAGAGCAAGAGGGGCTGGTGGGTCCCATGGAGATCACC
ATGGGGTCTCTGGAGAAGGCAGGGCCTGTGAGCCCAGGATGTGTGAAGCTGGCAGGGCAG
GAGGGCCTGGTGGAGATGGTGCTATTGATGGAGCCAGGGGCGATGCGCTTCCTGCAGCTC
TACCATGAGGACCTTCTTGCGGGCCTGGGAGACGTCGCTCTCTTGCCACTTGAAGGACCG
GATATGACTGGCTTTCGGCTCTGTGGAGCCCAGGCTTCCTGCCAGGCGGCTGAGGAGTTT
CTGCGGAGCCTGCTGGGCAGCATTAGCTGCCATGTGTTGTGCCTGGAGCACCCGGGCAGC
GCCAGGTTTCTCCTGGGCCCAGAAGGGCAGCACCTTCTCCAGGGGCTGGAGGCTCAGTTC
CAGTGTGTCTTTGGGACAGAGCGCCTGGCCACAGCCACGTTGGACACAGGCCTTGAAGAG
GTGGACCCTACCGAGGCCCTCCCAGTGCTCCCTGGCAACGCCCACACCCTGTGGACCCCA
GACAGTACAGGTGGTGACCAGGAGGACGTGAGCCTGGAGGAGGTCCGAGAACTGCTGGCC
ACCCTGGAGGGCCTAGACCTAGACGGGGAGGACTGGCTGCCTCGGGAGCTGGAGGAGGAA
GGGCCTCAGGAGCAGCCAGAGGAGGAGGTGACCCCAGGGCATGAGGAGGAGGAGCCTGTG
GCCCCCAGCACTGTGGCACCCAGGTGGCTGGAGGAGGAGGCCGCTCTGCAGCTGGCCCTC
CACCGGTCACTGGAGCCTCAAGGTCAGGTGGCTGAGCAGGAGGAGGCTGCTGCCCTGCGG
CAAGCCCTAACCCTCTCCCTGCTGGAGCAGCCCCCGTTGGAGGCAGAAGAGCCCCCAGAT
GGGGGGACTGATGGCAAGGCCCAGCTGGTGGTGCACTCGGCCTTTGAGCAGGATGTGGAG
GAGCTGGACCGGGCGCTCAGGGCTGCCTTGGAGGTCCACGTCCAGGAGGAGACGGTGGGG
CCCTGGCGCCGCACACTGCCTGCAGAGCTGCGTGCTCGCCTGGAGCGGTGCCATGGTGTG
AGTGTTGCCCTGCGTGGTGACTGCACCATCCTCCGTGGCTTCGGGGCCCACCCTGCCCGT
GCTGCCCGCCACTTGGTGGCACTTCTGGCTGGCCCCTGGGATCAGAGTTTGGCCTTTCCC
TTGGCAGCTTCAGGCCCTACCTTGGCGGGGCAGACGCTGAAGGGGCCCTGGAACAACCTG
GAGCGTCTGGCAGAGAACACCGGGGAGTTCCAGGAGGTGGTGCGGGCCTTCTACGACACC
CTGGACGCTGCCCGCAGCAGCATCCGCGTCGTTCGTGTGGAGCGCGTGTCGCACCCGCTG
CTGCAGCAGCAGTATGAGCTGTACCGGGAGCGCCTGCTGCAGCGATGCGAGCGGCGCCCG
GTGGAGCAGGTGCTGTACCACGGCACGACGGCACCGGCAGTGCCTGACATCTGCGCCCAC
GGCTTCAACCGCAGCTTCTGCGGCCGCAACGCCACGGTCTACGGGAAGGGCGTGTATTTC
GCCAGGCGCGCCTCCCTGTCGGTGCAGGACCGCTACTCGCCCCCCAACGCCGATGGCCAT
AAGGCGGTGTTCGTGGCACGGGTGCTGACTGGCGACTACGGGCAGGGCCGCCGCGGTCTG
CGGGCGCCCCCTCTGCGGGGTCCTGGCCACGTGCTCCTGCGCTACGACAGCGCCGTGGAC
TGCATCTGCCAGCCCAGCATCTTCGTCATCTTCCACGACACCCAGGCGCTGCCCACCCAC
CTCATCACCTGCGAGCACGTGCCCCGCGCTTCCCCCGGCGACCCCTCTGGGCTCCCGGGC
CGCTCCCCAGACACTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1025 |
| Molecular Weight
| 109997.35 |
| Theoretical pI
| 4.968 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Poly [ADP-ribose] polymerase 10
MVAMAEAEAGVAVEVRGLPPAVPDELLTLYFENRRRSGGGPVLSWQRLGCGGVLTFREPA
DAERVLAQADHELHGAQLSLRPAPPRAPARLLLQGLPPGTTPQRLEQHVQALLRASGLPV
QPCCALASPRPDRALVQLPKPLSEADVRVLEEQAQNLGLEGTLVSLARVPQARAVRVVGD
GASVDLLLLELYLENERRSGGGPLEDLQRLPGPLGTVASFQQWQVAERVLQQEHRLQGSE
LSLVPHYDILEPEELAENTSGGDHPSTQGPRATKHALLRTGGLVTALQGAGTVTMGSGEE
PGQSGASLRTGPMVQGRGIMTTGSGQEPGQSGTSLRTGPMGSLGQAEQVSSMPMGSLEHE
GLVSLRPVGLQEQEGPMSLGPVGSAGPVETSKGLLGQEGLVEIAMDSPEQEGLVGPMEIT
MGSLEKAGPVSPGCVKLAGQEGLVEMVLLMEPGAMRFLQLYHEDLLAGLGDVALLPLEGP
DMTGFRLCGAQASCQAAEEFLRSLLGSISCHVLCLEHPGSARFLLGPEGQHLLQGLEAQF
QCVFGTERLATATLDTGLEEVDPTEALPVLPGNAHTLWTPDSTGGDQEDVSLEEVRELLA
TLEGLDLDGEDWLPRELEEEGPQEQPEEEVTPGHEEEEPVAPSTVAPRWLEEEAALQLAL
HRSLEPQGQVAEQEEAAALRQALTLSLLEQPPLEAEEPPDGGTDGKAQLVVHSAFEQDVE
ELDRALRAALEVHVQEETVGPWRRTLPAELRARLERCHGVSVALRGDCTILRGFGAHPAR
AARHLVALLAGPWDQSLAFPLAASGPTLAGQTLKGPWNNLERLAENTGEFQEVVRAFYDT
LDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAH
GFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGL
RAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSGLPG
RSPDT
|
| External Links |
|---|
| GenBank ID Protein
| 62897387 |
| UniProtKB/Swiss-Prot ID
| Q53GL7 |
| UniProtKB/Swiss-Prot Entry Name
| PAR10_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK222914 |
| GeneCard ID
| PARP10 |
| GenAtlas ID
| PARP10 |
| HGNC ID
| HGNC:25895 |
| References |
|---|
| General References
| Not Available |