Showing Protein Forkhead box protein O4 (CDBP04072)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04072
Secondary Accession Numbers Not Available
Name Forkhead box protein O4
Description Not Available
Synonyms
  1. Fork head domain transcription factor AFX1
Gene Name FOXO4
Protein Type Transcription Factor
Biological Properties
General Function Involved in sequence-specific DNA binding transcription factor activity
Specific Function Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
sequence-specific dna binding transcription factor activity
binding
nucleic acid binding
dna binding
sequence-specific dna binding
Process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs FOXO4
Gene Sequence 
>1518 bp
ATGGATCCGGGGAATGAGAATTCAGCCACAGAGGCTGCCGCGATCATAGACCTAGATCCC
GACTTCGAACCCCAGAGCCGTCCCCGCTCCTGCACCTGGCCCCTTCCCCGACCAGAGATC
GCTAACCAGCCGTCCGAGCCGCCCGAGGTGGAGCCAGATCTGGGGGAAAAGGTACACACG
GAGGGGCGCTCAGAGCCGATCCTGTTGCCCTCTCGGCTCCCAGAGCCGGCCGGGGGCCCC
CAGCCCGGAATCCTGGGGGCTGTAACAGGTCCTCGGAAGGGAGGCTCCCGCCGGAATGCC
TGGGGAAATCAGTCATATGCAGAACTCATCAGCCAGGCCATTGAAAGCGCCCCGGAGAAG
CGACTGACACTTGCCCAGATCTACGAGTGGATGGTCCGTACTGTACCCTACTTCAAGGAC
AAGGGTGACAGCAACAGCTCAGCAGGATGGAAGAACTCGATCCGCCACAACCTGTCCCTG
CACAGCAAGTTCATCAAGGTTCACAACGAGGCCACCGGCAAAAGCTCTTGGTGGATGCTG
AACCCTGAGGGAGGCAAGAGCGGCAAAGCCCCCCGCCGCCGGGCCGCCTCCATGGATAGC
AGCAGCAAGCTGCTCCGGGGCCGCAGTAAAGCCCCCAAGAAGAAACCATCTGTGCTGCCA
GCTCCACCCGAAGGTGCCACTCCAACGAGCCCTGTCGGCCACTTTGCCAAGTGGTCAGGC
AGCCCTTGCTCTCGAAACCGTGAAGAAGCCGATATGTGGACCACCTTCCGTCCACGAAGC
AGTTCAAATGCCAGCAGTGTCAGCACCCGGCTGTCCCCCTTGAGGCCAGAGTCTGAGGTG
CTGGCGGAGGAAATACCAGCTTCAGTCAGCAGTTATGCAGGGGGTGTCCCTCCCACCCTC
AATGAAGGTCTAGAGCTGTTAGATGGGCTCAATCTCACCTCTTCCCATTCCCTGCTATCT
CGGAGTGGTCTCTCTGGCTTCTCTTTGCAGCATCCTGGGGTTACCGGCCCCTTACACACC
TACAGCAGCTCCCTTTTCAGCCCAGCAGAGGGGCCCCTGTCAGCAGGAGAAGGGTGCTTC
TCCAGCTCCCAGGCTCTGGAGGCCCTGCTCACCTCTGATACGCCACCACCCCCTGCTGAC
GTCCTCATGACCCAGGTAGATCCCATTCTGTCCCAGGCTCCGACTCTTCTGTTGCTGGGG
GGGCTTCCTTCCTCCAGTAAGCTGGCCACGGGCGTCGGCCTGTGTCCCAAGCCCCTAGAG
GCTCCAGGCCCCAGCAGTCTGGTTCCCACCCTTTCTATGATAGCACCACCTCCAGTCATG
GCAAGTGCCCCCATCCCCAAGGCTCTGGGGACTCCTGTGCTCACACCCCCTACTGAAGCT
GCAAGCCAAGACAGAATGCCTCAGGATCTAGATCTTGATATGTATATGGAGAACCTGGAG
TGTGACATGGATAACATCATCAGTGACCTCATGGATGAGGGCGAGGGACTGGACTTCAAC
TTTGAGCCAGATCCCTGA
Protein Properties
Number of Residues 505
Molecular Weight 53683.8
Theoretical pI 4.89
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Forkhead box protein O4
MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHT
EGRSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEK
RLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWML
NPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSG
SPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTL
NEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCF
SSSQALEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGLPSSSKLATGVGLCPKPLE
APGPSSLVPTLSMIAPPPVMASAPIPKALGTPVLTPPTEAASQDRMPQDLDLDMYMENLE
CDMDNIISDLMDEGEGLDFNFEPDP
GenBank ID Protein 103472003
UniProtKB/Swiss-Prot ID P98177
UniProtKB/Swiss-Prot Entry Name FOXO4_HUMAN
PDB IDs
GenBank Gene ID NM_005938.3
GeneCard ID FOXO4
GenAtlas ID FOXO4
HGNC ID HGNC:7139
References
General References Not Available