Showing Protein 17-beta-hydroxysteroid dehydrogenase 14 (CDBP04071)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04071
Secondary Accession Numbers Not Available
Name 17-beta-hydroxysteroid dehydrogenase 14
Description Not Available
Synonyms
  1. 17-beta-HSD 14
  2. 17-beta-hydroxysteroid dehydrogenase DHRS10
  3. Dehydrogenase/reductase SDR family member 10
  4. Retinal short-chain dehydrogenase/reductase retSDR3
Gene Name HSD17B14
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro)
GO Classification
Function
binding
catalytic activity
oxidoreductase activity
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19q13.33
SNPs HSD17B14
Gene Sequence 
>813 bp
ATGGCTACGGGAACGCGCTATGCCGGGAAGGTGGTGGTCGTGACCGGGGGCGGGCGCGGC
ATCGGAGCTGGGATCGTGCGCGCCTTCGTGAACAGCGGGGCCCGAGTGGTTATCTGCGAC
AAGGATGAGTCTGGGGGCCGGGCCCTGGAGCAGGAGCTCCCTGGAGCTGTCTTTATCCTC
TGTGATGTGACTCAGGAAGATGATGTGAAGACCCTGGTTTCTGAGACCATCCGCCGATTT
GGCCGCCTGGATTGTGTTGTCAACAACGCTGGCCACCACCCACCCCCACAGAGGCCTGAG
GAGACCTCTGCCCAGGGATTCCGCCAGCTGCTGGAGCTGAACCTACTGGGGACGTACACC
TTGACCAAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACATCTCC
AGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCA
GTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAAC
TGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCA
GACCCTAGGGCCTCAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAG
CCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGC
ATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGC
ACCCCCGTGGACGCCCCCGATATCCCTTCCTGA
Protein Properties
Number of Residues 270
Molecular Weight 28317.2
Theoretical pI 5.86
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>17-beta-hydroxysteroid dehydrogenase 14
MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL
CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT
LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN
CISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTG
IELLVTGGAELGYGCKASRSTPVDAPDIPS
GenBank ID Protein 6318546
UniProtKB/Swiss-Prot ID Q9BPX1
UniProtKB/Swiss-Prot Entry Name DHB14_HUMAN
PDB IDs
GenBank Gene ID AF126781
GeneCard ID HSD17B14
GenAtlas ID HSD17B14
HGNC ID HGNC:23238
References
General References Not Available