| Identification |
|---|
| HMDB Protein ID
| CDBP04068 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aldehyde dehydrogenase family 8 member A1 |
| Description
| Not Available |
| Synonyms
|
- Aldehyde dehydrogenase 12
|
| Gene Name
| ALDH8A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro) |
| GO Classification
|
| Function |
| catalytic activity |
| oxidoreductase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q23.2 |
| SNPs
| ALDH8A1 |
| Gene Sequence
|
>1464 bp
ATGGCTGGAACAAACGCACTTTTGATGCTGGAAAACTTCATAGATGGAAAATTTTTACCT
TGTAGCTCATATATAGATTCTTACGACCCATCAACAGGGGAAGTGTATTGCAGAGTGCCA
AATAGTGGAAAAGACGAGATCGAAGCCGCGGTCAAGGCCGCCAGAGAAGCCTTTCCCAGC
TGGTCATCCCGCAGCCCCCAGGAGCGCTCACGGGTCCTGAACCAGGTGGCGGATTTGCTG
GAGCAGTCCCTGGAGGAGTTTGCCCAGGCCGAGTCTAAAGACCAAGGGAAAACCTTAGCA
CTGGCAAGAACCATGGACATTCCCCGGTCTGTGCAGAACTTCAGGTTCTTCGCTTCCTCC
AGCCTGCACCACACGTCAGAGTGCACGCAGATGGACCACCTGGGCTGCATGCACTACACG
GTGCGGGCCCCGGTGGGAGTCGCTGGTCTGATCAGCCCCTGGAATTTGCCACTCTACTTG
CTGACCTGGAAGATAGCTCCAGCGATGGCTGCAGGGAACACTGTGATAGCCAAGCCCAGT
GAGCTGACTTCAGTGACTGCGTGGATGTTGTGCAAACTCCTGGATAAAGCAGGTGTTCCA
CCAGGTGTGGTCAATATTGTGTTTGGAACCGGGCCCAGGGTGGGTGAGGCCCTGGTGTCC
CACCCAGAGGTGCCCCTGATCTCCTTCACCGGGAGCCAGCCCACCGCTGAGCGGATCACC
CAGCTGAGCGCTCCCCACTGCAAAAAGCTCTCCCTGGAGCTGGGGGGCAAGAATCCTGCC
ATCATCTTTGAGGACGCCAACCTGGATGAGTGCATTCCGGCAACCGTCAGGTCCAGCTTT
GCCAACCAGGGTGAAATCTGTCTCTGTACCAGCAGGATCTTTGTCCAGAAGAGCATCTAT
AGTGAATTTTTAAAGAGATTTGTAGAAGCTACCAGAAAGTGGAAAGTCGGCATTCCCTCT
GATCCACTGGTGAGCATAGGTGCTCTGATAAGTAAAGCACATTTGGAGAAAGTCAGAAGT
TACGTCAAGAGAGCTCTTGCTGAAGGTGCCCAAATTTGGTGCGGTGAGGGAGTGGATAAG
TTGAGCCTCCCTGCCAGGAACCAGGCAGGCTACTTTATGCTTCCCACGGTGATAACAGAC
ATTAAGGATGAATCCTGCTGCATGACGGAAGAGATATTTGGTCCAGTGACGTGTGTCGTC
CCCTTTGATAGTGAAGAGGAGGTGATTGAAAGAGCCAACAACGTTAAGTATGGGCTGGCG
GCTACCGTGTGGTCCAGCAATGTGGGGCGCGTCCACCGGGTGGCTAAGAAGCTGCAGTCT
GGCTTGGTCTGGACCAACTGCTGGCTCATCAGGGAGCTGAACCTTCCTTTCGGGGGGATG
AAGAGTTCTGGAATAGGTAGAGAGGGAGCCAAGGACTCTTACGACTTCTTCACTGAGATC
AAAACCATCACCGTTAAACACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 487 |
| Molecular Weight
| 53400.9 |
| Theoretical pI
| 7.16 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Aldehyde dehydrogenase family 8 member A1
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS
WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS
SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS
ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT
QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY
SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK
LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA
ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI
KTITVKH
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9H2A2 |
| UniProtKB/Swiss-Prot Entry Name
| AL8A1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF303134 |
| GeneCard ID
| ALDH8A1 |
| GenAtlas ID
| ALDH8A1 |
| HGNC ID
| HGNC:15471 |
| References |
|---|
| General References
| Not Available |