| Identification |
|---|
| HMDB Protein ID
| CDBP04065 |
| Secondary Accession Numbers
| Not Available |
| Name
| Xaa-Pro aminopeptidase 1 |
| Description
| Not Available |
| Synonyms
|
- Aminoacylproline aminopeptidase
- Cytosolic aminopeptidase P
- Soluble aminopeptidase P
- X-Pro aminopeptidase 1
- X-prolyl aminopeptidase 1, soluble
- sAmp
|
| Gene Name
| XPNPEP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro |
| GO Classification
|
| Function |
| metalloexopeptidase activity |
| catalytic activity |
| hydrolase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| metallopeptidase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| cellular process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q25.3 |
| SNPs
| XPNPEP1 |
| Gene Sequence
|
>1872 bp
ATGCCTCCAAAGGTGACTTCAGAGCTGCTTCGGCAGCTGAGACAAGCCATGAGGAACTCT
GAGTATGTGACCGAACCGATCCAGGCCTACATCATCCCATCGGGAGATGCTCATCAGAGT
GAGTATATTGCTCCATGTGACTGTCGGCGGGCTTTTGTCTCTGGATTCGATGGCTCTGCG
GGCACAGCCATCATCACAGAAGAGCATGCAGCCATGTGGACTGACGGGCGCTACTTTCTC
CAGGCTGCCAAGCAAATGGACAGCAACTGGACACTTATGAAGATGGGTCTGAAGGACACA
CCAACTCAGGAAGACTGGCTGGTGAGTGTGCTTCCTGAAGGATCCAGGGTTGGTGTGGAC
CCCTTGATCATTCCTACAGATTATTGGAAGAAAATGGCCAAAGTTCTGAGAAGTGCCGGC
CATCACCTCATTCCTGTCAAGGAGAACCTCGTTGACAAAATCTGGACAGACCGTCCTGAG
CGCCCTTGCAAGCCTCTCCTCACACTGGGCCTGGATTACACAGGCATCTCCTGGAAGGAC
AAGGTTGCAGACCTTCGGTTGAAAATGGCTGAGAGGAACGTCATGTGGTTTGTGGTCACT
GCCTTGGATGAGATTGCGTGGCTATTTAATCTCCGAGGATCAGATGTGGAGCACAATCCA
GTATTTTTCTCCTACGCAATCATAGGACTAGAGACGATCATGCTCTTCATTGATGGTGAC
CGCATAGACGCCCCCAGTGTGAAGGAGCACCTGCTTCTTGACTTGGGTCTGGAAGCCGAA
TACAGGATCCAGGTGCATCCCTACAAGTCCATCCTGAGCGAGCTCAAGGCCCTGTGTGCT
GACCTCTCCCCAAGGGAGAAGGTGTGGGTCAGTGACAAGGCCAGCTATGCTGTGAGCGAG
ACCATCCCCAAGGACCACCGCTGCTGTATGCCTTACACCCCCATCTGCATCGCCAAAGCT
GTGAAGAATTCAGCTGAGTCAGAAGGCATGAGGCCGGCTCACATTAAAGATGCTGTTGCT
CTCTGTGAACTCTTTAACTGGCTGGAGAAAGAGGTTCCCAAAGGTGGTGTGACAGAGATC
TCAGCTGCTGACAAAGCTGAGGAGTTTCGCAGGCAACAGGCAGACTTTGTGGACCTGAGC
TTCCCAACAATTTCCAGTACGGGACCCAACGGCGCCATCATTCACTACGCGCCAGTCCCT
GAGACGAATAGGACCTTGTCCCTGGATGAGGTGTACCTTATTGACTCGGGTGCTCAATAC
AAGGATGGCACCACAGATGTGACGCGGACAATGCATTTTGGGACCCCTACAGCCTACGAG
AAGGAATGCTTCACATATGTCCTCAAGGGCCACATAGCTGTGAGTGCAGCCGTTTTCCCG
ACTGGAACCAAAGGTCACCTTCTTGACTCCTTTGCCCGTTCAGCTTTATGGGATTCAGGC
CTAGATTACTTGCACGGGACTGGACATGGTGTTGGGTCTTTTTTGAATGTCCATGAGGGT
CCTTGCGGCATCAGTTACAAAACATTCTCTGATGAGCCCTTGGAGGCAGGCATGATTGTC
ACTGATGAGCCCGGGTACTATGAAGATGGGGCTTTTGGAATTCGCATTGAGAATGTTGTC
CTTGTGGTTCCTGTGAAGACCAAGTATAATTTTAATAACCGGGGAAGCCTGACCTTTGAA
CCTCTAACATTGGTTCCAATTCAGACCAAAATGATAGATGTGGATTCTCTTACAGACAAA
GAGTGCGACTGGCTCAACAATTACCACCTGACCTGCAGGGATGTGATTGGGAAGGAATTG
CAGAAACAGGGCCGCCAGGAAGCTCTCGAGTGGCTCATCAGAGAGACGCAACCCATCTCC
AAACAGCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 623 |
| Molecular Weight
| 69917.2 |
| Theoretical pI
| 5.41 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Xaa-Pro aminopeptidase 1
MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSA
GTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVD
PLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKD
KVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGD
RIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSE
TIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEI
SAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQY
KDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSG
LDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVV
LVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKEL
QKQGRQEALEWLIRETQPISKQH
|
| External Links |
|---|
| GenBank ID Protein
| 9739017 |
| UniProtKB/Swiss-Prot ID
| Q9NQW7 |
| UniProtKB/Swiss-Prot Entry Name
| XPP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF195530 |
| GeneCard ID
| XPNPEP1 |
| GenAtlas ID
| XPNPEP1 |
| HGNC ID
| HGNC:12822 |
| References |
|---|
| General References
| Not Available |