| Identification |
|---|
| HMDB Protein ID
| CDBP04055 |
| Secondary Accession Numbers
| Not Available |
| Name
| GDP-fucose protein O-fucosyltransferase 1 |
| Description
| Not Available |
| Synonyms
|
- O-FucT-1
- Peptide-O-fucosyltransferase 1
|
| Gene Name
| POFUT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in peptide-O-fucosyltransferase activity |
| Specific Function
| Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Endoplasmic reticulum
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q11 |
| SNPs
| POFUT1 |
| Gene Sequence
|
>1167 bp
ATGGGCGCCGCCGCGTGGGCACGGCCGCTGAGCGTGTCTTTCCTGCTGCTGCTTCTGCCG
CTCCCGGGGATGCCCGCGGGCTCCTGGGACCCGGCCGGTTACCTGCTCTACTGCCCCTGC
ATGGGGCGCTTTGGGAACCAGGCCGATCACTTCTTGGGCTCTCTGGCATTTGCAAAGCTG
CTAAACCGTACCTTGGCTGTCCCTCCTTGGATTGAGTACCAGCATCACAAGCCTCCTTTC
ACCAACCTCCATGTGTCCTACCAGAAGTACTTCAAGCTGGAGCCCCTCCAGGCTTACCAT
CGGGTCATCAGCTTGGAGGATTTCATGGAGAAGCTGGCACCCACCCACTGGCCCCCTGAG
AAGCGGGTGGCATACTGCTTTGAGGTGGCAGCCCAGCGAAGCCCAGATAAGAAGACGTGC
CCCATGAAGGAAGGAAACCCCTTTGGCCCATTCTGGGATCAGTTTCATGTGAGTTTCAAC
AAGTCGGAGCTTTTTACAGGCATTTCCTTCAGTGCTTCCTACAGAGAACAATGGAGCCAG
AGATTTTCTCCAAAGGAACATCCGGTGCTTGCCCTGCCAGGAGCCCCAGCCCAGTTCCCC
GTCCTAGAGGAACACAGGCCACTACAGAAGTACATGGTATGGTCAGACGAAATGGTGAAG
ACGGGAGAGGCCCAGATTCATGCCCACCTTGTCCGGCCCTATGTGGGCATTCATCTGCGC
ATTGGCTCTGACTGGAAGAACGCCTGTGCCATGCTGAAGGACGGGACTGCAGGCTCGCAC
TTCATGGCCTCTCCGCAGTGTGTGGGCTACAGCCGCAGCACAGCGGCCCCCCTCACGATG
ACTATGTGCCTGCCTGACCTGAAGGAGATCCAGAGGGCTGTGAAGCTCTGGGTGAGGTCG
CTGGATGCCCAGTCGGTCTACGTTGCTACTGATTCCGAGAGTTATGTGCCTGAGCTCCAA
CAGCTCTTCAAAGGGAAGGTGAAGGTGGTGAGCCTGAAGCCTGAGGTGGCCCAGGTCGAC
CTGTACATCCTCGGCCAAGCCGACCACTTTATTGGCAACTGTGTCTCCTCCTTCACTGCC
TTTGTGAAGCGGGAGCGGGACCTCCAGGGGAGGCCGTCTTCTTTCTTCGGCATGGACAGG
CCCCCTAAGCTGCGGGACGAGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 388 |
| Molecular Weight
| 43955.4 |
| Theoretical pI
| 8.69 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>GDP-fucose protein O-fucosyltransferase 1
MGAAAWARPLSVSFLLLLLPLPGMPAGSWDPAGYLLYCPCMGRFGNQADHFLGSLAFAKL
LNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQAYHRVISLEDFMEKLAPTHWPPE
KRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYREQWSQ
RFSPKEHPVLALPGAPAQFPVLEEHRPLQKYMVWSDEMVKTGEAQIHAHLVRPYVGIHLR
IGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTAAPLTMTMCLPDLKEIQRAVKLWVRS
LDAQSVYVATDSESYVPELQQLFKGKVKVVSLKPEVAQVDLYILGQADHFIGNCVSSFTA
FVKRERDLQGRPSSFFGMDRPPKLRDEF
|
| External Links |
|---|
| GenBank ID Protein
| 15825114 |
| UniProtKB/Swiss-Prot ID
| Q9H488 |
| UniProtKB/Swiss-Prot Entry Name
| OFUT1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF375884 |
| GeneCard ID
| POFUT1 |
| GenAtlas ID
| POFUT1 |
| HGNC ID
| HGNC:14988 |
| References |
|---|
| General References
| Not Available |