| Identification |
|---|
| HMDB Protein ID
| CDBP04053 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carnosine synthase 1 |
| Description
| Not Available |
| Synonyms
|
- ATP-grasp domain-containing protein 1
|
| Gene Name
| CARNS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.
|
| GO Classification
|
| Biological Process |
| carnosine biosynthetic process |
| Function |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| binding |
| catalytic activity |
| nucleoside binding |
| purine nucleoside binding |
| Molecular Function |
| metal ion binding |
| ATP binding |
| ATPase activity |
| carnosine synthase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Histidine Metabolism |    |  | | Histidinemia |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q13.2 |
| SNPs
| CARNS1 |
| Gene Sequence
|
>2484 bp
ATGCTCCTTTGCCTGTCCCCTGCTTGGCTGATGAAGGTGCCAGCACCCGGGCAGCCGGGT
GAGGCAGCCCTGCTAGTCTCCAAGGCTGTGAGCTTCCACCCTGGGGGCCTGACATTCCTG
GATGACTTTGTCCCCCCGCGCCGTGCCACCTACTTTTTGGCAGGCCTGGGCCTGGGGCCT
GGCCGGGGCCGAGAGGCAGCAGAACTCGCCCGTGACCTGACCTGCCCCACAGGAGCTTCG
GCTGAGCTGGCCCGGCTGCTGGAGGACCGGCTGCTGACAAGGCAGTTGCTGGCCCAGCAG
GGTGGTGTGGCTGTGCCAGCAACCCTGGCTTTCACCTACAAGCCGCCGGGGCTGCTGCGG
GGAGGGGATGCCAGCCTAGGGCTACGGCTGGTGGAGCTGAGTGGCAAAGAGGGCCAGGAG
ACGCTGGTGAAAGAGGAAGTGGAGGCTTTTCTGCGCTCCGAGGCCCTGGGTGATATCCTG
CAGGTAGCTGTGAAGCTCAGTGGCTGGCGCTGGCGGGGGCGGCAGGCATGGCGTCTGCAC
CCGCGGGCAGAGCTGGGTGCAGTGGTGGACACAGTGCTGGCGCTGCTGGAGAAGCTGGAG
GAGGAGGAGAGTGTCCTGGTGGAGGCTGTGTACCCACCTGCCCAGCTGCCCTGCTCAGAT
GGTCCTTCACCCGGCCCCGGCCTGGCCGTGCGAATCTGTGCTGTGGTGTGTCGGACACAG
GGTGATAGGCCACTGCTGAGCAAGGTGGTGTGCGGCGTGGGCCGCGGGGACCGCCCTCTA
CGGCACCACAACTCCCTGCCGAGGACGCTGGAGGTGGCGCTGGCCCAGTGCGGCCTGGGC
GAGGAGGCGCAGGTGGCGGCTGTGCGGCAGCGCGTCAAGGCGGCGGCCGAGGCCGCGCTG
GCCGCCGTGCTGGCTCTGGAGGCCGGCCTGAGTGCCGAGCAGCGCGGCGGGCGCCGGGCG
CACACGGACTTCCTGGGCGTGGATTTCGCGCTGACAGCGGCCGGCGGCGTGCTGACCCCA
GTGGCCCTGGAGCTGAACGGCGGCCTGTGTCTGGAGGCGTGCGGCGCGCTGGAGGGGCTG
TGGGCCGCGCCGCGGCTGGGGCCGGCGGCCGACGAGGCGGTGGCGGCGCCGCTGGTGGAG
ACCATGCTTCGGCGGTCGGCGCGCTGCCTCATGGAGGGAAAACAGCTGCTGGTGGTCGGC
GCTGGCGGCGTCAGCAAGAAGTTCGTGTGGGAGGCGGCGCGCGACTACGGGCTCCAGCTG
CACCTCGTGGAGTCAGACCCCAACCACTTTGCATCCCAGTTGGTACAGACCTTCATCCAC
TTTGACATGACAGAGCACCGGAGGGATGAGGAGAACGCACGGCTGCTGGCAGAGTTGGTG
CGGGCTCGCGGCCTCAAGCTAGATGGCTGCTTCTCCTACTGGGATGACTGCCTGGTGCTC
ACAGCCCTGCTCTGCCAGGAGCTAGGTCTGCCCTGCAGCTCCCCAGCTGCCATGCGCCTG
GCTAAGCAGAAGAGCCTCACCCAGCTGCACCTGTTGCACCACCATGGCCCACCCTGGCCT
GCGCCCTCCCTCCATGCTGTGCCCTGCTGCCCACTGGAGAGTGAGGCTGATGTGGAGAGG
GCCGTGCACCAGGTACCCCTGCCAGGTGTCATGAAGCTGGAGTTCGGGGCAGGTGCAGTG
GGTGTCCGGCTGGTAGAGGATGCGCCACAGTGCCATGAGCACTTTTCCCGGATTACCCGA
GACTTGCAGGGCGAGGCCGACCACCCAGGCATTGGGCTGGGCTGGGGCAATGCCATGCTG
CTGATGGAGTTTGTGGAGGGCACCGAGCACGACGTGGACCTGGTGTTGTTTGGTGGGCGG
TTGCTGGCTGCCTTTGTCTCCGACAATGGCCCTACGAGGCTGCCTGGCTTCACTGAGACG
GCGGCCTGCATGCCCACCGGGCTGGCACCAGAGCAGGAGGCACAGATGGTTCAGGCAGCC
TTCCGCTGTTGCCTGGGCTGCGGGTTGCTCGATGGAGTCTTCAACGTGGAGCTCAAGCTG
ACCGGGGCTGGGCCTCGGCTTATCGAGATCAACCCCCGCATGGGTGGCTTCTACCTGCGT
GATTGGATCCTGGAGCTCTATGGTGTTGACCTGCTGCTGGCTGCTGTTATGGTGGCCTGT
GGCTTGCGTCCTGCCCTGCCCACCCGCCCACGTGCTCGTGGCCATCTGGTGGGCGTCATG
TGCCTTGTGTCCCAGCACCTGCAGGCCCTGAGTTCCACCGCCAGCCGTGAGACCCTGCAG
GCCCTGCACGACCGTGGACTGCTACGCCTCAATCTGCTGGAGGAGGCCCTGGTGCCTGGC
GAGTATGAGGAGCCCTACTGCAGTGTGGCCTGTGCCGGACCCAGCCCCACCGAGGCCCGT
CTCCGCCTGCTGGGCCTCTGCCAGGGCCTGGGCATCGATGGGCCCAGCTACCCTGTTGCC
CACTTCCTGTCTCACTTCAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 827 |
| Molecular Weight
| 101318.725 |
| Theoretical pI
| 5.69 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Carnosine synthase 1
MLLCLSPAWLMKVPAPGQPGEAALLVSKAVSFHPGGLTFLDDFVPPRRATYFLAGLGLGP
GRGREAAELARDLTCPTGASAELARLLEDRLLTRQLLAQQGGVAVPATLAFTYKPPGLLR
GGDASLGLRLVELSGKEGQETLVKEEVEAFLRSEALGDILQVAVKLSGWRWRGRQAWRLH
PRAELGAVVDTVLALLEKLEEEESVLVEAVYPPAQLPCSDGPSPGPGLAVRICAVVCRTQ
GDRPLLSKVVCGVGRGDRPLRHHNSLPRTLEVALAQCGLGEEAQVAAVRQRVKAAAEAAL
AAVLALEAGLSAEQRGGRRAHTDFLGVDFALTAAGGVLTPVALELNGGLCLEACGALEGL
WAAPRLGPAADEAVAAPLVETMLRRSARCLMEGKQLLVVGAGGVSKKFVWEAARDYGLQL
HLVESDPNHFASQLVQTFIHFDMTEHRRDEENARLLAELVRARGLKLDGCFSYWDDCLVL
TALLCQELGLPCSSPAAMRLAKQKSLTQLHLLHHHGPPWPAPSLHAVPCCPLESEADVER
AVHQVPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGIGLGWGNAML
LMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFTETAACMPTGLAPEQEAQMVQAA
FRCCLGCGLLDGVFNVELKLTGAGPRLIEINPRMGGFYLRDWILELYGVDLLLAAVMVAC
GLRPALPTRPRARGHLVGVMCLVSQHLQALSSTASRETLQALHDRGLLRLNLLEEALVPG
EYEEPYCSVACAGPSPTEARLRLLGLCQGLGIDGPSYPVAHFLSHFK
|
| External Links |
|---|
| GenBank ID Protein
| 148839342 |
| UniProtKB/Swiss-Prot ID
| A5YM72 |
| UniProtKB/Swiss-Prot Entry Name
| CRNS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020811.1 |
| GeneCard ID
| CARNS1 |
| GenAtlas ID
| CARNS1 |
| HGNC ID
| HGNC:29268 |
| References |
|---|
| General References
| Not Available |