| Identification |
|---|
| HMDB Protein ID
| CDBP04052 |
| Secondary Accession Numbers
| Not Available |
| Name
| Interferon-stimulated gene 20 kDa protein |
| Description
| Not Available |
| Synonyms
|
- Estrogen-regulated transcript 45 protein
- Promyelocytic leukemia nuclear body-associated protein ISG20
|
| Gene Name
| ISG20 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in exonuclease activity |
| Specific Function
| Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| exonuclease activity |
| nucleic acid binding |
| nuclease activity |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q26 |
| SNPs
| ISG20 |
| Gene Sequence
|
>546 bp
ATGGCTGGGAGCCGTGAGGTGGTGGCCATGGACTGCGAGATGGTGGGGCTGGGGCCCCAC
CGGGAGAGTGGCCTGGCTCGTTGCAGCCTCGTGAACGTCCACGGTGCTGTGCTGTACGAC
AAGTTCATCCGGCCTGAGGGAGAGATCACCGATTACAGAACCCGGGTCAGCGGGGTCACC
CCTCAGCACATGGTGGGGGCCACACCATTTGCCGTGGCCAGGCTAGAGATCCTGCAGCTC
CTGAAAGGCAAGCTGGTGGTGGGTCATGACCTGAAGCACGACTTCCAGGCACTGAAAGAG
GACATGAGCGGCTACACAATCTACGACACGTCCACTGACAGGCTGTTGTGGCGTGAGGCC
AAGCTGGACCACTGCAGGCGTGTCTCCCTGCGGGTGCTGAGTGAGCGCCTCCTGCACAAG
AGCATCCAGAACAGCCTGCTTGGACACAGCTCGGTGGAAGATGCGAGGGCAACGATGGAG
CTCTATCAAATCTCCCAGAGAATCCGAGCCCGCCGAGGGCTGCCCCGCCTGGCTGTGTCA
GACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 181 |
| Molecular Weight
| 20363.3 |
| Theoretical pI
| 9.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Interferon-stimulated gene 20 kDa protein
MAGSREVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTRVSGVT
PQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGYTIYDTSTDRLLWREA
KLDHCRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATMELYQISQRIRARRGLPRLAVS
D
|
| External Links |
|---|
| GenBank ID Protein
| 6759541 |
| UniProtKB/Swiss-Prot ID
| Q96AZ6 |
| UniProtKB/Swiss-Prot Entry Name
| ISG20_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X89773 |
| GeneCard ID
| ISG20 |
| GenAtlas ID
| ISG20 |
| HGNC ID
| HGNC:6130 |
| References |
|---|
| General References
| Not Available |