| Identification |
|---|
| HMDB Protein ID
| CDBP04051 |
| Secondary Accession Numbers
| Not Available |
| Name
| Galactose-3-O-sulfotransferase 4 |
| Description
| Not Available |
| Synonyms
|
- Beta-galactose-3-O-sulfotransferase 4
- Gal-beta-1,3-GalNAc 3'-sulfotransferase
- Gal3ST-4
|
| Gene Name
| GAL3ST4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in galactosylceramide sulfotransferase activity |
| Specific Function
| Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc |
| GO Classification
|
| Component |
| golgi apparatus |
| cell part |
| membrane part |
| intrinsic to membrane |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| integral to membrane |
| Function |
| sulfotransferase activity |
| galactose 3-o-sulfotransferase activity |
| galactosylceramide sulfotransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| Process |
| metabolic process |
| biosynthetic process |
|
| Cellular Location
|
- Golgi apparatus
- Golgi stack membrane
- Single-pass type II membrane protein (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q22.1 |
| SNPs
| GAL3ST4 |
| Gene Sequence
|
>1461 bp
ATGGGCCCTCTCTCTCCTGCCAGGACGCTGCGGCTCTGGGGACCTCGGAGCCTGGGGGTG
GCTCTGGGAGTCTTCATGACCATTGGCTTTGCACTCCAGCTCTTGGGAGGGCCCTTCCAG
AGGAGGCTACCTGGGCTACAGCTCCGACAGCCCTCGGCCCCATCCCTACGACCAGCCCTT
CCGTCCTGCCCACCCCGGCAGCGACTGGTGTTCCTGAAGACACATAAATCCGGGAGCAGC
TCTGTGCTGAGCCTGCTTCACCGCTATGGGGACCAGCACGGGCTGCGCTTCGCCCTCCCT
GCCCGCTACCAGTTTGGCTACCCAAAGCTCTTCCAGGCCTCTAGGGTAAAAGGCTACCGC
CCACAGGGTGGAGGCACCCAGCTCCCCTTCCACATCCTCTGTCACCACATGAGGTTCAAC
CTGAAAGAGGTACTTCAGGTCATGCCTTCTGACAGCTTCTTTTTTTCCATTGTCCGAGAC
CCAGCGGCTCTGGCTCGCTCTGCCTTCTCCTACTATAAATCCACCTCATCAGCCTTCCGC
AAGTCACCATCTTTGGCTGCCTTCCTGGCCAATCCTCGAGGCTTCTACAGGCCTGGGGCC
GTGGGGACCACTTACGCTCGCAACTTACTATGGTTTGACTTTGGCCTGCCCTTTCCCCCA
GAGAAGAGGGCCAAGAGAGGGAATATTCATCCCCCCAGAGACCCCAACCCCCCACAGCTG
CAGGTCTTGCCTTCTGGTGCTGGCCCTCGAGCCCAAACCCTCAATCCCAATGCCCTCATC
CATCCTGTTTCCACTGTTACTGATCATCGCAGCCAGATATCAAGCCCTGCCTCTTTCGAT
TTGGGGTCTTCATCCTTCATCCAGTGGGGTCTGGCCTGGCTGGACTCTGTCTTTGACCTG
GTCATGGTGGCTGAGTACTTCGATGAGTCATTGGTTCTGCTGGCAGATGCCCTGTGCTGG
GGTCTAGATGACGTGGTGGGCTTCATGCACAATGCCCAGGCTGGACATAAGCAGGGCCTC
AGCACTGTCAGCAACAGTGGACTGACTGCGGAGGACCGGCAGCTGACTGCACGGGCCCGA
GCCTGGAACAACCTGGACTGGGCTCTCTATGTCCACTTCAACCGCAGTCTCTGGGCACGG
ATAGAGAAATACGGCCAGGGCCGGCTGCAGACAGCTGTGGCCGAGCTCCGGGCTCGCCGA
GAGGCCCTAGCGAAACATTGTCTGGTAGGGGGTGAGGCTTCTGACCCCAAATACATCACT
GATCGCCGGTTCCGCCCCTTCCAGTTTGGGTCAGCTAAGGTTTTGGGCTATATACTTCGG
AGTGGATTGAGCCCCCAAGACCAAGAGGAATGTGAGCGCCTAGCTACCCCTGAGCTCCAG
TACAAGGACAAGCTGGATGTCAAGCAGTTCCCCCCTACCGTCTCACTGCCCCTCAAGACT
TCAAGGCCACTCTCCCCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 486 |
| Molecular Weight
| 54165.6 |
| Theoretical pI
| 10.71 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Galactose-3-O-sulfotransferase 4
MGPLSPARTLRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLPGLQLRQPSAPSLRPAL
PSCPPRQRLVFLKTHKSGSSSVLSLLHRYGDQHGLRFALPARYQFGYPKLFQASRVKGYR
PQGGGTQLPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFR
KSPSLAAFLANPRGFYRPGARGDHYARNLLWFDFGLPFPPEKRAKRGNIHPPRDPNPPQL
QVLPSGAGPRAQTLNPNALIHPVSTVTDHRSQISSPASFDLGSSSFIQWGLAWLDSVFDL
VMVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGHKQGLSTVSNSGLTAEDRQLTARAR
AWNNLDWALYVHFNRSLWARIEKYGQGRLQTAVAELRARREALAKHCLVGGEASDPKYIT
DRRFRPFQFGSAKVLGYILRSGLSPQDQEECERLATPELQYKDKLDAKQFPPTVSLPLKT
SRPLSP
|
| External Links |
|---|
| GenBank ID Protein
| 18027354 |
| UniProtKB/Swiss-Prot ID
| Q96RP7 |
| UniProtKB/Swiss-Prot Entry Name
| G3ST4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF289575 |
| GeneCard ID
| GAL3ST4 |
| GenAtlas ID
| GAL3ST4 |
| HGNC ID
| HGNC:24145 |
| References |
|---|
| General References
| Not Available |